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ADGRF5 adhesion G protein-coupled receptor F5 [ Homo sapiens (human) ]

Gene ID: 221395, updated on 11-Jul-2021

Summary

Official Symbol
ADGRF5provided by HGNC
Official Full Name
adhesion G protein-coupled receptor F5provided by HGNC
Primary source
HGNC:HGNC:19030
See related
Ensembl:ENSG00000069122
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPR116; KPG_001
Expression
Broad expression in lung (RPKM 71.0), fat (RPKM 49.8) and 16 other tissues See more
Orthologs
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Genomic context

See ADGRF5 in Genome Data Viewer
Location:
6p12.3
Exon count:
25
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (46852522..46954954, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (46820259..46922676, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 66 Neighboring gene meprin A subunit alpha Neighboring gene ADGRF5 antisense RNA 1 Neighboring gene uncharacterized LOC105375080 Neighboring gene adhesion G protein-coupled receptor F1 Neighboring gene Sharpr-MPRA regulatory region 10363

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ90640, KIAA0758, DKFZp564O1923

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in energy reserve metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in erythrocyte development IEA
Inferred from Electronic Annotation
more info
 
involved_in fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in glomerular filtration IEA
Inferred from Electronic Annotation
more info
 
involved_in glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of macrophage activation IEA
Inferred from Electronic Annotation
more info
 
involved_in pharyngeal arch artery morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in surfactant homeostasis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in apical part of cell IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
adhesion G protein-coupled receptor F5
Names
G-protein coupled receptor 116
Ig-Hepta homolog
probable G-protein coupled receptor 116

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098518.2NP_001091988.1  adhesion G protein-coupled receptor F5 precursor

    See identical proteins and their annotated locations for NP_001091988.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AB018301, AL096772, AY140958, AY498875, DB230925
    Consensus CDS
    CCDS4919.1
    UniProtKB/Swiss-Prot
    Q8IZF2
    Related
    ENSP00000283296.7, ENST00000283296.12
    Conserved Domains (6) summary
    smart00408
    Location:285351
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:477562
    IG_like; Immunoglobulin like
    pfam00001
    Location:10301268
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam01390
    Location:170259
    SEA; SEA domain
    pfam01825
    Location:954996
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:10111262
    7tm_4; Olfactory receptor
  2. NM_015234.5NP_056049.4  adhesion G protein-coupled receptor F5 precursor

    See identical proteins and their annotated locations for NP_056049.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AL096772, AY140958, AY498875, DA588699
    Consensus CDS
    CCDS4919.1
    UniProtKB/Swiss-Prot
    Q8IZF2
    Related
    ENSP00000265417.6, ENST00000265417.7
    Conserved Domains (6) summary
    smart00408
    Location:285351
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:477562
    IG_like; Immunoglobulin like
    pfam00001
    Location:10301268
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam01390
    Location:170259
    SEA; SEA domain
    pfam01825
    Location:954996
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:10111262
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    46852522..46954954 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010421.2XP_016865910.1  adhesion G protein-coupled receptor F5 isoform X5

  2. XM_017010419.2XP_016865908.1  adhesion G protein-coupled receptor F5 isoform X4

    Conserved Domains (6) summary
    smart00408
    Location:285351
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:477562
    IG_like; Immunoglobulin like
    pfam00001
    Location:10301268
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam01390
    Location:170259
    SEA; SEA domain
    pfam01825
    Location:954996
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:10111262
    7tm_4; Olfactory receptor
  3. XM_017010418.2XP_016865907.1  adhesion G protein-coupled receptor F5 isoform X3

    Conserved Domains (6) summary
    smart00408
    Location:285351
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:517602
    IG_like; Immunoglobulin like
    pfam00001
    Location:10701308
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam01390
    Location:170259
    SEA; SEA domain
    pfam01825
    Location:9941036
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:10511302
    7tm_4; Olfactory receptor
  4. XM_017010420.2XP_016865909.1  adhesion G protein-coupled receptor F5 isoform X5

  5. XM_011514353.3XP_011512655.1  adhesion G protein-coupled receptor F5 isoform X4

    Conserved Domains (6) summary
    smart00408
    Location:285351
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:477562
    IG_like; Immunoglobulin like
    pfam00001
    Location:10301268
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam01390
    Location:170259
    SEA; SEA domain
    pfam01825
    Location:954996
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:10111262
    7tm_4; Olfactory receptor
  6. XM_005248892.3XP_005248949.1  adhesion G protein-coupled receptor F5 isoform X1

    See identical proteins and their annotated locations for XP_005248949.1

    Conserved Domains (6) summary
    smart00408
    Location:285351
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:517602
    IG_like; Immunoglobulin like
    pfam00001
    Location:10701308
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam01390
    Location:170259
    SEA; SEA domain
    pfam01825
    Location:9941036
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:10511302
    7tm_4; Olfactory receptor
  7. XM_005248895.4XP_005248952.1  adhesion G protein-coupled receptor F5 isoform X3

    Conserved Domains (6) summary
    smart00408
    Location:285351
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:517602
    IG_like; Immunoglobulin like
    pfam00001
    Location:10701308
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam01390
    Location:170259
    SEA; SEA domain
    pfam01825
    Location:9941036
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:10511302
    7tm_4; Olfactory receptor
  8. XM_005248894.4XP_005248951.1  adhesion G protein-coupled receptor F5 isoform X2

    Conserved Domains (6) summary
    smart00408
    Location:285351
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:517602
    IG_like; Immunoglobulin like
    pfam00001
    Location:10701308
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam01390
    Location:170259
    SEA; SEA domain
    pfam01825
    Location:9941036
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:10511302
    7tm_4; Olfactory receptor
  9. XM_017010424.2XP_016865913.1  adhesion G protein-coupled receptor F5 isoform X9

  10. XM_005248893.3XP_005248950.1  adhesion G protein-coupled receptor F5 isoform X1

    See identical proteins and their annotated locations for XP_005248950.1

    Conserved Domains (6) summary
    smart00408
    Location:285351
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:517602
    IG_like; Immunoglobulin like
    pfam00001
    Location:10701308
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam01390
    Location:170259
    SEA; SEA domain
    pfam01825
    Location:9941036
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:10511302
    7tm_4; Olfactory receptor
  11. XM_017010422.2XP_016865911.1  adhesion G protein-coupled receptor F5 isoform X6

  12. XM_017010423.1XP_016865912.1  adhesion G protein-coupled receptor F5 isoform X8

  13. XM_011514354.2XP_011512656.1  adhesion G protein-coupled receptor F5 isoform X7

    Conserved Domains (6) summary
    smart00408
    Location:112178
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:344429
    IG_like; Immunoglobulin like
    pfam00001
    Location:8971135
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam01390
    Location:586
    SEA; SEA domain
    pfam01825
    Location:821863
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:8781129
    7tm_4; Olfactory receptor
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