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ADGRF4 adhesion G protein-coupled receptor F4 [ Homo sapiens (human) ]

Gene ID: 221393, updated on 13-Mar-2020

Summary

Official Symbol
ADGRF4provided by HGNC
Official Full Name
adhesion G protein-coupled receptor F4provided by HGNC
Primary source
HGNC:HGNC:19011
See related
Ensembl:ENSG00000153294 MIM:614268
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PGR18; GPR115
Summary
Sequence analysis of this gene suggests that it is encodes a member of the superfamily of G protein-couple receptors. G protein-coupled receptors typically contain seven hydrophobic transmembrane domains, interact with guanine nucleotide binding regulatory proteins, and detect molecules outside the cell and act to transduce these signals into intracellular responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2016]
Expression
Biased expression in skin (RPKM 17.6), esophagus (RPKM 6.4) and 3 other tissues See more
Orthologs

Genomic context

See ADGRF4 in Genome Data Viewer
Location:
6p12.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (47698580..47722014)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (47666289..47689757)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene CD2 associated protein Neighboring gene DnaJ heat shock protein family (Hsp40) member C17 pseudogene Neighboring gene adhesion G protein-coupled receptor F2 Neighboring gene RN7SK pseudogene 116 Neighboring gene ribosomal protein L27a pseudogene 7 Neighboring gene opsin 5 Neighboring gene RNA, U1 small nuclear 105, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Potential readthrough

Included gene: ADGRF2

Homology

Clone Names

  • FLJ38076

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
adhesion G protein-coupled receptor F4
Names
G-protein coupled receptor PGR18
probable G-protein coupled receptor 115
seven transmembrane helix receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052799.1 RefSeqGene

    Range
    17682..41158
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001347855.2NP_001334784.1  adhesion G protein-coupled receptor F4 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK095395, AY140957, BU683873
    Consensus CDS
    CCDS4922.2
    UniProtKB/Swiss-Prot
    Q8IZF3
    Related
    ENSP00000328319.3, ENST00000327753.7
  2. NM_153838.5NP_722580.3  adhesion G protein-coupled receptor F4 precursor

    See identical proteins and their annotated locations for NP_722580.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AY255556, BU683873, DB313938, DQ315370
    Consensus CDS
    CCDS4922.2
    UniProtKB/Swiss-Prot
    Q8IZF3
    Related
    ENSP00000283303.2, ENST00000283303.3
    Conserved Domains (2) summary
    pfam01825
    Location:347390
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:400648
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    47698580..47722014
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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