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OPN5 opsin 5 [ Homo sapiens (human) ]

Gene ID: 221391, updated on 9-Jun-2025
Official Symbol
OPN5provided by HGNC
Official Full Name
opsin 5provided by HGNC
Primary source
HGNC:HGNC:19992
See related
Ensembl:ENSG00000124818 MIM:609042; AllianceGenome:HGNC:19992
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PGR12; GPR136; GRP136; TMEM13
Summary
Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This opsin gene is expressed in the eye, brain, testes, and spinal cord. This gene belongs to the seven-exon subfamily of mammalian opsin genes that includes peropsin (RRH) and retinal G protein coupled receptor (RGR). Like these other seven-exon opsin genes, this family member may encode a protein with photoisomerase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
Expression
Restricted expression toward testis (RPKM 1.6) See more
Orthologs
mouse all
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See OPN5 in Genome Data Viewer
Location:
6p12.3
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (47782032..47826381)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (47623816..47668165)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (47749768..47794117)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene adhesion G protein-coupled receptor F4 Neighboring gene RN7SK pseudogene 116 Neighboring gene ribosomal protein L27a pseudogene 7 Neighboring gene RNA, U1 small nuclear 105, pseudogene Neighboring gene uncharacterized LOC107986601 Neighboring gene patched domain containing 4 Neighboring gene Sharpr-MPRA regulatory region 3755 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:48078458-48079657

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. The opsins. Terakita A. Genome Biol, 2005. PMID 15774036, Free PMC Article
  2. Light-induced rapid Ca²⁺ response and MAPK phosphorylation in the cells heterologously expressing human OPN5. Sugiyama T, et al. Sci Rep, 2014 Jun 19. PMID 24941910, Free PMC Article
  3. Human neuropsin gene in depression. Bobińska K, et al. Psychiatr Danub, 2017 Jun. PMID 28636578
  4. Neuropsin in mental health. Bukowski L, et al. J Physiol Sci, 2020 May 15. PMID 32414324, Free PMC Article
  5. Genetic variations of human neuropsin gene and psychiatric disorders: polymorphism screening and possible association with bipolar disorder and cognitive functions. Izumi A, et al. Neuropsychopharmacology, 2008 Dec. PMID 18354391

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Neuropsin in mental health.
    Title: Neuropsin in mental health.
  2. Expression of the hNP gene on the mRNA level, evaluated based on peripheral blood, is significantly higher in the patients with MRD than in the healthy subjects.
    Title: Human neuropsin gene in depression.
  3. Data indicate that opsin5 (OPN5) photoreceptor mediates light-induced Ca(2+) response.
    Title: Light-induced rapid Ca²⁺ response and MAPK phosphorylation in the cells heterologously expressing human OPN5.
  4. It dissects a schizophrenic susceptibility gene, NRG1.
    Title: [Neuropsin signaling as a novel therapeutic target of schizophrenia].
  5. Opn5m may work exclusively as a short wavelength sensor in the brain as well as in the retina with the assistance of an 11-cis-retinal-supplying system.
    Title: Evolution of mammalian Opn5 as a specialized UV-absorbing pigment by a single amino acid mutation.
  6. UV photoreceptor in human beings OPN5 triggers a UV-sensitive Gi-mediated signaling pathway in the mammalian tissues.
    Title: UV-sensitive photoreceptor protein OPN5 in humans and mice.
  7. Genetic variation of the hNP gene may contribute to molecular mechanisms of bipolar disorder and some aspects of memory and intelligence.
    Title: Genetic variations of human neuropsin gene and psychiatric disorders: polymorphism screening and possible association with bipolar disorder and cognitive functions.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 11-cis retinal binding IEA
Inferred from Electronic Annotation
more info
  
enables 11-cis retinal binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables G protein-coupled photoreceptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled photoreceptor activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled photoreceptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables photoreceptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to UV-A IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to light stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to light stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to light stimulus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in detection of visible light IEA
Inferred from Electronic Annotation
more info
  
involved_in entrainment of circadian clock by photoperiod IEA
Inferred from Electronic Annotation
more info
  
involved_in entrainment of circadian clock by photoperiod ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in hyaloid vascular plexus regression IEA
Inferred from Electronic Annotation
more info
  
involved_in hyaloid vascular plexus regression ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phototransduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phototransduction IEA
Inferred from Electronic Annotation
more info
  
involved_in phototransduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phototransduction, UV IEA
Inferred from Electronic Annotation
more info
  
involved_in phototransduction, UV IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in visual perception IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in photoreceptor outer segment IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
opsin-5
Names
G-protein coupled receptor 136
neuropsin
transmembrane protein 13

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181744.4 → NP_859528.1  opsin-5

    See identical proteins and their annotated locations for NP_859528.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the supported protein.
    Source sequence(s)
    AL161622, AL356421
    Consensus CDS
    CCDS4923.1
    UniProtKB/Swiss-Prot
    A0AV33, Q5T5B9, Q5T886, Q6U736, Q7Z603, Q86SL5
    UniProtKB/TrEMBL
    J3KPQ2
    Related
    ENSP00000360255.2, ENST00000371211.7
    Conserved Domains (1) summary
    cd15074
    Location:34 → 316
    7tmA_Opsin5_neuropsin; neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors

RNA

  1. NR_033806.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two 5' exons but includes a different 5' exon, and also contains an additional internal exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC042544, BX647224, DB056067
    Related
    ENST00000244799.4

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    47782032..47826381
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010416.2 → XP_016865905.1  opsin-5 isoform X6

    UniProtKB/TrEMBL
    J3KPQ2

  2. XM_017010410.2 → XP_016865899.1  opsin-5 isoform X1

  3. XM_017010411.2 → XP_016865900.1  opsin-5 isoform X2

    UniProtKB/TrEMBL
    J3KPQ2

  4. XM_017010413.2 → XP_016865902.1  opsin-5 isoform X3

  5. XM_017010412.2 → XP_016865901.1  opsin-5 isoform X3

  6. XM_047418325.1 → XP_047274281.1  opsin-5 isoform X5

  7. XM_017010414.2 → XP_016865903.1  opsin-5 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    47623816..47668165
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054354561.1 → XP_054210536.1  opsin-5 isoform X6

    UniProtKB/TrEMBL
    J3KPQ2

  2. XM_054354555.1 → XP_054210530.1  opsin-5 isoform X1

  3. XM_054354556.1 → XP_054210531.1  opsin-5 isoform X2

    UniProtKB/TrEMBL
    J3KPQ2

  4. XM_054354558.1 → XP_054210533.1  opsin-5 isoform X3

  5. XM_054354557.1 → XP_054210532.1  opsin-5 isoform X3

  6. XM_054354560.1 → XP_054210535.1  opsin-5 isoform X5

  7. XM_054354559.1 → XP_054210534.1  opsin-5 isoform X4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001030051.1: Suppressed sequence

    Description
    NM_001030051.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6U736.3 GenPept UniProtKB/Swiss-Prot:Q6U736

Gene LinkOut

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