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GSTA5 glutathione S-transferase alpha 5 [ Homo sapiens (human) ]

Gene ID: 221357, updated on 11-Jun-2021

Summary

Official Symbol
GSTA5provided by HGNC
Official Full Name
glutathione S-transferase alpha 5provided by HGNC
Primary source
HGNC:HGNC:19662
See related
Ensembl:ENSG00000182793 MIM:607605
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The glutathione S-transferases (GST; EC 2.5.1.18) catalyze the conjugation of reduced glutathiones and a variety of electrophiles, including many known carcinogens and mutagens. The cytosolic GSTs belong to a large superfamily, with members located on different chromosomes. For additional information on GSTs, see GSTA1 (MIM 138359).[supplied by OMIM, Sep 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See GSTA5 in Genome Data Viewer
Location:
6p12.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (52831692..52846245, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (52696540..52710893, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase alpha 1 Neighboring gene glutathione S-transferase alpha 6, pseudogene Neighboring gene glutathione S-transferase alpha 11, pseudogene Neighboring gene uncharacterized LOC105375091 Neighboring gene glutathione S-transferase alpha 10, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glutathione transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in glutathione metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in xenobiotic metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in extracellular exosome HDA PubMed 

General protein information

Preferred Names
glutathione S-transferase A5
Names
GST class-alpha member 5
glutathione S-transferase A5-5
NP_714543.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153699.2NP_714543.1  glutathione S-transferase A5

    See identical proteins and their annotated locations for NP_714543.1

    Status: VALIDATED

    Source sequence(s)
    AL590363
    Consensus CDS
    CCDS4946.1
    UniProtKB/Swiss-Prot
    Q7RTV2
    Related
    ENSP00000360028.1, ENST00000370989.6
    Conserved Domains (3) summary
    PTZ00057
    Location:1198
    PTZ00057; glutathione s-transferase; Provisional
    cd03208
    Location:86220
    GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
    cd03077
    Location:482
    GST_N_Alpha; GST_N family, Class Alpha subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    52831692..52846245 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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