Format

Send to:

Choose Destination

ZUP1 zinc finger containing ubiquitin peptidase 1 [ Homo sapiens (human) ]

Gene ID: 221302, updated on 21-Dec-2019

Summary

Official Symbol
ZUP1provided by HGNC
Official Full Name
zinc finger containing ubiquitin peptidase 1provided by HGNC
Primary source
HGNC:HGNC:21224
See related
Ensembl:ENSG00000153975
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DUB; ZUFSP; C6orf113
Summary
This gene encodes a protein containing zinc finger motifs and a cysteine peptidase domain. The encoded protein functions as a K63-specific de-ubiquitinating enzyme that specifically cleaves long K63-linked polyubiquitin chains in the middle of a chain (i.e. "endo cleavage) rather than by removing the terminal ubiquitin from a chain. This enzyme is thought to be involved in the regulation of DNA repair by cleaving K63-linked ubiquitin chains at repair foci. This protein is related to proteases for the ubiquitin-like modifiers Ufm1 (ubiquitin fold modifier 1) and Atg8/Gabarapl2, but does not have any activity on these modifiers. [provided by RefSeq, Mar 2018]
Expression
Ubiquitous expression in duodenum (RPKM 4.7), bone marrow (RPKM 4.6) and 25 other tissues See more
Orthologs

Genomic context

See ZUP1 in Genome Data Viewer
Location:
6q22.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (116635618..116668810, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (116956781..116989973, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene RWD domain containing 1 Neighboring gene radial spoke head component 4A Neighboring gene karyopherin subunit alpha 5 Neighboring gene family with sequence similarity 162 member B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of zinc finger with UFM1-specific peptidase domain (ZUFSP) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
thiol-dependent ubiquitinyl hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger-containing ubiquitin peptidase 1
Names
lys-63-specific deubiquitinase ZUFSP
ubiquitin carboxyl-terminal hydrolase ZUFSP
zinc finger with UFM1-specific peptidase domain protein
NP_001348118.1
NP_001348119.1
NP_001348120.1
NP_659499.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361189.1NP_001348118.1  zinc finger-containing ubiquitin peptidase 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL132795
    Conserved Domains (1) summary
    pfam07910
    Location:336551
    Peptidase_C78; Peptidase family C78
  2. NM_001361190.1NP_001348119.1  zinc finger-containing ubiquitin peptidase 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL132795
    Conserved Domains (1) summary
    pfam07910
    Location:168383
    Peptidase_C78; Peptidase family C78
  3. NM_001361191.1NP_001348120.1  zinc finger-containing ubiquitin peptidase 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL132795
    Conserved Domains (1) summary
    pfam07910
    Location:140355
    Peptidase_C78; Peptidase family C78
  4. NM_145062.3NP_659499.2  zinc finger-containing ubiquitin peptidase 1 isoform 1

    See identical proteins and their annotated locations for NP_659499.2

    Status: REVIEWED

    Source sequence(s)
    BC016879
    Consensus CDS
    CCDS5110.1
    UniProtKB/Swiss-Prot
    Q96AP4
    UniProtKB/TrEMBL
    A0A0S2Z644
    Related
    ENSP00000357565.3, ENST00000368576.8
    Conserved Domains (1) summary
    pfam07910
    Location:336551
    Peptidase_C78; Peptidase family C78

RNA

  1. NR_154586.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL132795
  2. NR_154587.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL132795
  3. NR_154588.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL132795
  4. NR_154589.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL132795

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    116635618..116668810 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center