Format

Send to:

Choose Destination

NT5DC1 5'-nucleotidase domain containing 1 [ Homo sapiens (human) ]

Gene ID: 221294, updated on 22-Aug-2020

Summary

Official Symbol
NT5DC1provided by HGNC
Official Full Name
5'-nucleotidase domain containing 1provided by HGNC
Primary source
HGNC:HGNC:21556
See related
Ensembl:ENSG00000178425
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LP2642; NT5C2L1; C6orf200
Summary
While the exact function of the protein encoded by this gene is not known, it belongs to the 5'(3')-deoxyribonucleotidase family. [provided by RefSeq, May 2010]
Expression
Ubiquitous expression in thyroid (RPKM 16.7), prostate (RPKM 14.4) and 25 other tissues See more
Orthologs

Genomic context

See NT5DC1 in Genome Data Viewer
Location:
6q22.1
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (116100833..116249497)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (116421999..116566853)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2534 Neighboring gene fyn related Src family tyrosine kinase Neighboring gene triosephosphate isomerase 1 pseudogene 3 Neighboring gene collagen type X alpha 1 chain Neighboring gene NIP7 pseudogene 3 Neighboring gene ribosomal protein S5 pseudogene Neighboring gene TSPY like 4 Neighboring gene RPS5 pseudogene 1 Neighboring gene dermatan sulfate epimerase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
GWAS of dental caries patterns in the permanent dentition.
GeneReviews: Not available
Seven new loci associated with age-related macular degeneration.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC24302, MGC131837

Gene Ontology Provided by GOA

Function Evidence Code Pubs
5'-nucleotidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
dephosphorylation IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
5'-nucleotidase domain-containing protein 1
Names
5'-nucleotidase, cytosolic II-like 1 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021351.1 RefSeqGene

    Range
    5001..149855
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_152729.3NP_689942.2  5'-nucleotidase domain-containing protein 1

    See identical proteins and their annotated locations for NP_689942.2

    Status: REVIEWED

    Source sequence(s)
    AL050331, AL121963, KF458258
    Consensus CDS
    CCDS5104.1
    UniProtKB/Swiss-Prot
    Q5TFE4
    UniProtKB/TrEMBL
    Q9H2R1
    Related
    ENSP00000326858.3, ENST00000319550.9
    Conserved Domains (1) summary
    cl17687
    Location:11337
    5_nucleotid; 5' nucleotidase family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    116100833..116249497
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006715378.3XP_006715441.1  5'-nucleotidase domain-containing protein 1 isoform X1

    Conserved Domains (1) summary
    cl17687
    Location:11299
    5_nucleotid; 5' nucleotidase family
Support Center