Format

Send to:

Choose Destination

AK9 adenylate kinase 9 [ Homo sapiens (human) ]

Gene ID: 221264, updated on 5-Aug-2018

Summary

Official Symbol
AK9provided by HGNC
Official Full Name
adenylate kinase 9provided by HGNC
Primary source
HGNC:HGNC:33814
See related
Ensembl:ENSG00000155085 MIM:615358; Vega:OTTHUMG00000157658
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AK 9; AKD1; AKD2; C6orf199; C6orf224; dJ70A9.1
Summary
The protein encoded by this gene catalyzes the interconversion of nucleosides, possessing both nucleoside monophosphate and diphosphate kinase activities. The encoded protein uses these interconversions to maintain nucleoside homeostasis. [provided by RefSeq, Jul 2016]
Expression
Broad expression in testis (RPKM 4.3), thyroid (RPKM 0.9) and 23 other tissues See more
Orthologs

Genomic context

See AK9 in Genome Data Viewer
Location:
6q21
Exon count:
48
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (109492855..109691212, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (109814059..110012415, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase like 6 Neighboring gene microtubule associated monooxygenase, calponin and LIM domain containing 1 Neighboring gene sphingomyelin phosphodiesterase 2 Neighboring gene uncharacterized LOC105377935 Neighboring gene zinc finger and BTB domain containing 24 Neighboring gene FIG4 phosphoinositide 5-phosphatase Neighboring gene uncharacterized LOC107986630

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16163, FLJ25791, FLJ34784, FLJ42177, MGC26954, MGC126763, MGC138153, MGC177059, MGC180194, MGC184281

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
nucleoside diphosphate kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
nucleoside kinase activity EXP
Inferred from Experiment
more info
PubMed 
nucleoside monophosphate kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
AMP phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
ATP generation from ADP IDA
Inferred from Direct Assay
more info
PubMed 
CDP phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
CMP phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
GDP phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
TDP phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
UDP phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
dADP phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
dAMP phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
dCDP phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
dCMP phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
dGDP phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
nucleobase-containing small molecule interconversion TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nuclear membrane IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
adenylate kinase 9
Names
adenylate kinase domain containing 1
adenylate kinase domain containing 2
NP_001138600.2
NP_001316531.1
NP_001316532.1
NP_659462.1
XP_006715439.2
XP_011533852.1
XP_011533854.1
XP_011533855.1
XP_011533856.1
XP_011533857.1
XP_011533858.1
XP_011533860.1
XP_011533861.1
XP_016865873.1
XP_016865874.1
XP_016865875.1
XP_016865876.1
XP_016865877.1
XP_016865878.1
XP_024302118.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145128.2NP_001138600.2  adenylate kinase 9 isoform 1

    See identical proteins and their annotated locations for NP_001138600.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL109947, AL121788, AL133472, AL139391
    Consensus CDS
    CCDS55048.1
    UniProtKB/Swiss-Prot
    Q5TCS8
    Related
    ENSP00000410186.2, ENST00000424296.6
    Conserved Domains (4) summary
    COG0563
    Location:14131575
    Adk; Adenylate kinase or related kinase [Nucleotide transport and metabolism]
    cd01428
    Location:9931161
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    TIGR01351
    Location:33277
    adk; adenylate kinase
    cl00909
    Location:945987
    Ribosomal_L24e_L24; Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor ...
  2. NM_001329602.1NP_001316531.1  adenylate kinase 9 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks multiple 3' exons and differs in the 5' UTR, as compared to variant 1. The resulting isoform (2) is much shorter at the C-terminus, as compared to isoform 1. Variants 2 and 3 both encode the same isoform (2).
    Source sequence(s)
    AL121788, AL133472
    Consensus CDS
    CCDS5077.1
    UniProtKB/Swiss-Prot
    Q5TCS8
    Conserved Domains (2) summary
    COG1341
    Location:347413
    Grc3; Polynucleotide 5'-kinase, involved in rRNA processing [Translation, ribosomal structure and biogenesis]
    cd01428
    Location:33276
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
  3. NM_001329603.1NP_001316532.1  adenylate kinase 9 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks multiple 3' exons and differs in the 5' UTR and coding sequence, as compared to variant 1. The resulting isoform (3) is much shorter at the C-terminus and longer at the N-terminus, as compared to isoform 1.
    Source sequence(s)
    AL121788, AL133472
  4. NM_145025.4NP_659462.1  adenylate kinase 9 isoform 2

    See identical proteins and their annotated locations for NP_659462.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks multiple 3' exons, as compared to variant 1. The resulting isoform (2) is much shorter at the C-terminus, as compared to isoform 1. Variants 2 and 3 both encode the same isoform (2).
    Source sequence(s)
    AK055538, BC022031
    Consensus CDS
    CCDS5077.1
    UniProtKB/Swiss-Prot
    Q5TCS8
    Related
    ENSP00000285397.4, OTTHUMP00000016973, ENST00000285397.9, OTTHUMT00000041765
    Conserved Domains (2) summary
    COG1341
    Location:347413
    Grc3; Polynucleotide 5'-kinase, involved in rRNA processing [Translation, ribosomal structure and biogenesis]
    cd01428
    Location:33276
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

RNA

  1. NR_138057.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks multiple 3' exons, differs in the 5' end, and uses an alternate splice junction, as compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AL121788, AL133472

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    109492855..109691212 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535552.3XP_011533854.1  adenylate kinase 9 isoform X3

    See identical proteins and their annotated locations for XP_011533854.1

    Conserved Domains (4) summary
    COG0563
    Location:14131580
    Adk; Adenylate kinase or related kinase [Nucleotide transport and metabolism]
    cd01428
    Location:9931161
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    TIGR01351
    Location:33277
    adk; adenylate kinase
    cl00909
    Location:945987
    Ribosomal_L24e_L24; Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor ...
  2. XM_017010385.2XP_016865874.1  adenylate kinase 9 isoform X6

  3. XM_011535554.2XP_011533856.1  adenylate kinase 9 isoform X4

    Conserved Domains (4) summary
    COG0563
    Location:13781545
    Adk; Adenylate kinase or related kinase [Nucleotide transport and metabolism]
    cd01428
    Location:9581126
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    TIGR01351
    Location:105349
    adk; adenylate kinase
    cl00909
    Location:910952
    Ribosomal_L24e_L24; Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor ...
  4. XM_006715376.3XP_006715439.2  adenylate kinase 9 isoform X2

    Conserved Domains (4) summary
    COG0563
    Location:14851647
    Adk; Adenylate kinase or related kinase [Nucleotide transport and metabolism]
    cd01428
    Location:10651233
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    TIGR01351
    Location:105349
    adk; adenylate kinase
    cl00909
    Location:10171059
    Ribosomal_L24e_L24; Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor ...
  5. XM_011535550.2XP_011533852.1  adenylate kinase 9 isoform X1

    Conserved Domains (2) summary
    cd01428
    Location:10651233
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    cl00909
    Location:10171059
    Ribosomal_L24e_L24; Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor ...
  6. XM_017010387.2XP_016865876.1  adenylate kinase 9 isoform X9

  7. XM_011535553.3XP_011533855.1  adenylate kinase 9 isoform X3

    See identical proteins and their annotated locations for XP_011533855.1

    Conserved Domains (4) summary
    COG0563
    Location:14131580
    Adk; Adenylate kinase or related kinase [Nucleotide transport and metabolism]
    cd01428
    Location:9931161
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    TIGR01351
    Location:33277
    adk; adenylate kinase
    cl00909
    Location:945987
    Ribosomal_L24e_L24; Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor ...
  8. XM_024446350.1XP_024302118.1  adenylate kinase 9 isoform X1

    Conserved Domains (2) summary
    cd01428
    Location:10651233
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    cl00909
    Location:10171059
    Ribosomal_L24e_L24; Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor ...
  9. XM_017010389.1XP_016865878.1  adenylate kinase 9 isoform X12

  10. XM_011535558.1XP_011533860.1  adenylate kinase 9 isoform X13

    Conserved Domains (3) summary
    COG0563
    Location:689856
    Adk; Adenylate kinase or related kinase [Nucleotide transport and metabolism]
    cd01428
    Location:269437
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    cl00909
    Location:221263
    Ribosomal_L24e_L24; Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor ...
  11. XM_017010386.1XP_016865875.1  adenylate kinase 9 isoform X7

  12. XM_017010384.1XP_016865873.1  adenylate kinase 9 isoform X5

  13. XM_011535555.2XP_011533857.1  adenylate kinase 9 isoform X8

    Conserved Domains (4) summary
    cd01428
    Location:10651233
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    TIGR01351
    Location:105349
    adk; adenylate kinase
    cl00909
    Location:10171059
    Ribosomal_L24e_L24; Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor ...
    cl17190
    Location:14851569
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  14. XM_011535556.3XP_011533858.1  adenylate kinase 9 isoform X10

    Conserved Domains (3) summary
    cd01428
    Location:10651233
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    TIGR01351
    Location:105349
    adk; adenylate kinase
    cl00909
    Location:10171059
    Ribosomal_L24e_L24; Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor ...
  15. XM_017010388.2XP_016865877.1  adenylate kinase 9 isoform X11

  16. XM_011535559.3XP_011533861.1  adenylate kinase 9 isoform X14

    Conserved Domains (4) summary
    cd01428
    Location:105348
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    TIGR01351
    Location:105349
    adk; adenylate kinase
    pfam13207
    Location:465581
    AAA_17; AAA domain
    cl00909
    Location:10171059
    Ribosomal_L24e_L24; Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor ...

RNA

  1. XR_942337.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001001706.2: Suppressed sequence

    Description
    NM_001001706.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the CDS appears to be partial at the 5' end.
  2. NM_173559.1: Suppressed sequence

    Description
    NM_173559.1: This RefSeq was permanently suppressed because the CDS was partial.
Support Center