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Gfus GDP-L-fucose synthase [ Mus musculus (house mouse) ]

Gene ID: 22122, updated on 9-Nov-2022

Summary

Official Symbol
Gfusprovided by MGI
Official Full Name
GDP-L-fucose synthaseprovided by MGI
Primary source
MGI:MGI:98857
See related
Ensembl:ENSMUSG00000022570 AllianceGenome:MGI:98857
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FX; Tsta3; Tstap35b
Summary
Predicted to enable GDP-L-fucose synthase activity; GDP-mannose 3,5-epimerase activity; and identical protein binding activity. Acts upstream of or within T cell mediated cytotoxicity. Orthologous to human GFUS (GDP-L-fucose synthase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 74.6), large intestine adult (RPKM 59.5) and 28 other tissues See more
Orthologs
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Genomic context

See Gfus in Genome Data Viewer
Location:
15 D3; 15 35.1 cM
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (75796521..75801670, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (75924669..75929821, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene tigger transposable element derived 5 Neighboring gene pyrroline-5-carboxylate reductase-like Neighboring gene zinc finger protein 623 Neighboring gene predicted gene, 53898

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC113801

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GDP-L-fucose synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GDP-L-fucose synthase activity ISO
Inferred from Sequence Orthology
more info
 
enables GDP-mannose 3,5-epimerase activity ISO
Inferred from Sequence Orthology
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
GDP-L-fucose synthase
Names
GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase
GDP-L-fucose synthetase
GDP-fucose synthase
protein FX
red cell NADP(H)-binding protein
tissue specific transplantation antigen P35B
transplantation antigen P35B
tum-P35B antigen
NP_001343934.1
NP_112478.1
XP_006520812.1
XP_006520813.1
XP_006520815.1
XP_006520816.1
XP_030104324.1
XP_030104325.1
XP_030104326.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357005.2NP_001343934.1  GDP-L-fucose synthase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC116520
    Consensus CDS
    CCDS27555.1
    UniProtKB/Swiss-Prot
    P23591
    UniProtKB/TrEMBL
    Q5HZI6
    Related
    ENSMUSP00000155139.2, ENSMUST00000229641.2
    Conserved Domains (1) summary
    cd05239
    Location:9312
    GDP_FS_SDR_e; GDP-fucose synthetase, extended (e) SDRs
  2. NM_001411815.1NP_001398744.1  GDP-L-fucose synthase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC116520
    UniProtKB/TrEMBL
    A0A2R8VI39
  3. NM_001411816.1NP_001398745.1  GDP-L-fucose synthase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC116520
    UniProtKB/TrEMBL
    A0A2R8VI39
  4. NM_031201.2NP_112478.1  GDP-L-fucose synthase isoform 1

    See identical proteins and their annotated locations for NP_112478.1

    Status: VALIDATED

    Source sequence(s)
    AC116520
    Consensus CDS
    CCDS27555.1
    UniProtKB/Swiss-Prot
    P23591
    UniProtKB/TrEMBL
    Q5HZI6
    Related
    ENSMUSP00000023231.6, ENSMUST00000023231.7
    Conserved Domains (1) summary
    cd05239
    Location:9312
    GDP_FS_SDR_e; GDP-fucose synthetase, extended (e) SDRs

RNA

  1. NR_177931.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC116520
  2. NR_177932.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC116520
  3. NR_177933.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC116520
  4. NR_177934.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC116520
  5. NR_177935.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC116520
  6. NR_177936.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC116520
  7. NR_177937.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC116520
  8. NR_177938.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC116520

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    75796521..75801670 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520749.3XP_006520812.1  GDP-L-fucose synthase isoform X1

    Conserved Domains (1) summary
    cd05239
    Location:9342
    GDP_FS_SDR_e; GDP-fucose synthetase, extended (e) SDRs
  2. XM_030248466.2XP_030104326.1  GDP-L-fucose synthase isoform X4

    Conserved Domains (1) summary
    cl21454
    Location:42152
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  3. XM_030248464.2XP_030104324.1  GDP-L-fucose synthase isoform X3

    Conserved Domains (1) summary
    cd05239
    Location:13237
    GDP_FS_SDR_e; GDP-fucose synthetase, extended (e) SDRs
  4. XM_030248465.2XP_030104325.1  GDP-L-fucose synthase isoform X3

    Related
    ENSMUSP00000154964.2, ENSMUST00000229289.2
    Conserved Domains (1) summary
    cd05239
    Location:13237
    GDP_FS_SDR_e; GDP-fucose synthetase, extended (e) SDRs
  5. XM_006520753.4XP_006520816.1  GDP-L-fucose synthase isoform X2

    Conserved Domains (1) summary
    cl21454
    Location:13267
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  6. XM_006520752.5XP_006520815.1  GDP-L-fucose synthase isoform X2

    Conserved Domains (1) summary
    cl21454
    Location:13267
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  7. XM_006520750.5XP_006520813.1  GDP-L-fucose synthase isoform X1

    Related
    ENSMUSP00000155711.2, ENSMUST00000229951.2
    Conserved Domains (1) summary
    cd05239
    Location:9342
    GDP_FS_SDR_e; GDP-fucose synthetase, extended (e) SDRs

RNA

  1. XR_001781507.3 RNA Sequence

    Related
    ENSMUST00000229085.2
  2. XR_003951361.2 RNA Sequence

  3. XR_003951362.2 RNA Sequence

    Related
    ENSMUST00000230364.2