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ADGRG5 adhesion G protein-coupled receptor G5 [ Homo sapiens (human) ]

Gene ID: 221188, updated on 11-Jun-2021

Summary

Official Symbol
ADGRG5provided by HGNC
Official Full Name
adhesion G protein-coupled receptor G5provided by HGNC
Primary source
HGNC:HGNC:19010
See related
Ensembl:ENSG00000159618 MIM:616965
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PGR27; GPR114
Summary
This gene encodes a member of the adhesion family of G-protein coupled receptors. Members of this family are characterized by long N-termini and multiple functional domains. They may play a role in the immune system as well as in the central nervous system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Expression
Biased expression in lymph node (RPKM 4.6), spleen (RPKM 3.3) and 13 other tissues See more
Orthologs
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Genomic context

See ADGRG5 in Genome Data Viewer
Location:
16q21
Exon count:
13
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (57529339..57578182)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (57576555..57611101)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 83 Neighboring gene RNA polymerase II subunit C Neighboring gene docking protein 4 Neighboring gene coiled-coil domain containing 102A Neighboring gene uncharacterized LOC105371291 Neighboring gene uncharacterized LOC107984889 Neighboring gene high mobility group box 3 pseudogene 32

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
adhesion G-protein coupled receptor G5
Names
G protein-coupled receptor 114
G protein-coupled receptor PGR27
probable G-protein coupled receptor 114

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304376.3NP_001291305.1  adhesion G-protein coupled receptor G5 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001291305.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK292783, AY358447, BC032401, BM193863
    Consensus CDS
    CCDS10785.1
    UniProtKB/Swiss-Prot
    Q8IZF4
    Related
    ENSP00000290823.4, ENST00000349457.8
    Conserved Domains (2) summary
    pfam01825
    Location:187232
    GPS; GPCR proteolysis site, GPS, motif
    cd15443
    Location:245518
    7tmB2_GPR114; orphan adhesion receptor GPR114, member of the class B2 family of seven-transmembrane G protein-coupled receptors
  2. NM_001318481.2NP_001305410.1  adhesion G-protein coupled receptor G5 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate exon in the 3' coding region, resulting in a frameshift and an early stop codon, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK292783, AK303661, AY140956, BC032401, BM193863
    UniProtKB/Swiss-Prot
    Q8IZF4
    UniProtKB/TrEMBL
    B4E148
    Conserved Domains (2) summary
    pfam01825
    Location:187232
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:247363
    7tm_4; Olfactory receptor
  3. NM_153837.4NP_722579.1  adhesion G-protein coupled receptor G5 isoform 1 precursor

    See identical proteins and their annotated locations for NP_722579.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC004382, AK292783, AK303661, AY358447, BC032401, BM193863
    Consensus CDS
    CCDS10785.1
    UniProtKB/Swiss-Prot
    Q8IZF4
    UniProtKB/TrEMBL
    B4E148
    Related
    ENSP00000342981.4, ENST00000340339.4
    Conserved Domains (2) summary
    pfam01825
    Location:187232
    GPS; GPCR proteolysis site, GPS, motif
    cd15443
    Location:245518
    7tmB2_GPR114; orphan adhesion receptor GPR114, member of the class B2 family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    57529339..57578182
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522949.2XP_011521251.1  adhesion G-protein coupled receptor G5 isoform X1

    See identical proteins and their annotated locations for XP_011521251.1

    UniProtKB/Swiss-Prot
    Q8IZF4
    Conserved Domains (2) summary
    pfam01825
    Location:187232
    GPS; GPCR proteolysis site, GPS, motif
    cd15443
    Location:245518
    7tmB2_GPR114; orphan adhesion receptor GPR114, member of the class B2 family of seven-transmembrane G protein-coupled receptors
  2. XM_011522950.2XP_011521252.1  adhesion G-protein coupled receptor G5 isoform X1

    See identical proteins and their annotated locations for XP_011521252.1

    UniProtKB/Swiss-Prot
    Q8IZF4
    Conserved Domains (2) summary
    pfam01825
    Location:187232
    GPS; GPCR proteolysis site, GPS, motif
    cd15443
    Location:245518
    7tmB2_GPR114; orphan adhesion receptor GPR114, member of the class B2 family of seven-transmembrane G protein-coupled receptors
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