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CPNE2 copine 2 [ Homo sapiens (human) ]

Gene ID: 221184, updated on 5-Jul-2020

Summary

Official Symbol
CPNE2provided by HGNC
Official Full Name
copine 2provided by HGNC
Primary source
HGNC:HGNC:2315
See related
Ensembl:ENSG00000140848 MIM:604206
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CPN2; COPN2
Summary
Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. Sequence analysis identified multiple alternatively spliced transcript variants but their full-length natures could not be determined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lung (RPKM 25.9), fat (RPKM 23.8) and 24 other tissues See more
Orthologs

Genomic context

See CPNE2 in Genome Data Viewer
Location:
16q13
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (57092583..57148369)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (57126455..57182281)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 12884 Neighboring gene cilia and flagella associated protein 69 pseudogene Neighboring gene NLR family CARD domain containing 5 Neighboring gene uncharacterized LOC105371289 Neighboring gene Sharpr-MPRA regulatory region 3054 Neighboring gene proteasome activator subunit 3 interacting protein 1 Neighboring gene ring finger and SPRY domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC16924, DKFZp686E06199

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular response to calcium ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152727.6NP_689940.3  copine-2

    See identical proteins and their annotated locations for NP_689940.3

    Status: REVIEWED

    Source sequence(s)
    AC009090, AF492484, BG830959, CB306539, CN283840, DB504175
    Consensus CDS
    CCDS10774.1
    UniProtKB/Swiss-Prot
    Q96FN4
    Related
    ENSP00000290776.8, ENST00000290776.13
    Conserved Domains (3) summary
    cd04047
    Location:155267
    C2B_Copine; C2 domain second repeat in Copine
    cd04048
    Location:24141
    C2A_Copine; C2 domain first repeat in Copine
    pfam07002
    Location:326542
    Copine; Copine

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    57092583..57148369
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001751870.1 RNA Sequence

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