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SKA3 spindle and kinetochore associated complex subunit 3 [ Homo sapiens (human) ]

Gene ID: 221150, updated on 3-May-2025
Official Symbol
SKA3provided by HGNC
Official Full Name
spindle and kinetochore associated complex subunit 3provided by HGNC
Primary source
HGNC:HGNC:20262
See related
Ensembl:ENSG00000165480 MIM:619247; AllianceGenome:HGNC:20262
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAMA1; C13orf3
Summary
This gene encodes a component of the spindle and kinetochore-associated protein complex that regulates microtubule attachment to the kinetochores during mitosis. The encoded protein localizes to the outer kinetechore and may be required for normal chromosome segregation and cell division. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Expression
Biased expression in testis (RPKM 4.8), bone marrow (RPKM 3.0) and 13 other tissues See more
Orthologs
mouse all
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See SKA3 in Genome Data Viewer
Location:
13q12.11
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (21153595..21176552, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (20346668..20369632, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (21727734..21750691, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORD27 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7430 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7431 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7432 Neighboring gene Sin3A associated protein 18 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:21748764-21749486 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:21750209-21750931 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7433 Neighboring gene mitochondrial ribosomal protein L57 Neighboring gene OCT4 hESC enhancer GRCh37_chr13:21780309-21780832 Neighboring gene long intergenic non-protein coding RNA 1046

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Spindle and kinetochore‑associated complex subunit 3 accelerates breast cancer cell proliferation and invasion through the regulation of Akt/Wnt/β-catenin signaling. Zhang J, et al. Breast Cancer Res Treat, 2021 Feb. PMID 33423159
  2. Spindle and kinetochore-related complex subunit 3 has a protumour function in osteosarcoma by activating the Notch pathway. Liang G, et al. Toxicol Appl Pharmacol, 2024 Feb. PMID 38228236
  3. Upregulation of SKA3 enhances cell proliferation and correlates with poor prognosis in hepatocellular carcinoma. Tang J, et al. Oncol Rep, 2021 Apr. PMID 33760206
  4. Circ-SKA3 upregulates ID3 expression by decoying miR-326 to accelerate the development of medulloblastoma. Zhao X, et al. J Clin Neurosci, 2021 Apr. PMID 33775353
  5. SKA3 promotes glioblastoma proliferation and invasion by enhancing the activation of Wnt/β-catenin signaling via modulation of the Akt/GSK-3β axis. Li C, et al. Brain Res, 2021 Aug 15. PMID 33895155

See all (84) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Spindle and kinetochore-related complex subunit 3 has a protumour function in osteosarcoma by activating the Notch pathway.
    Title: Spindle and kinetochore-related complex subunit 3 has a protumour function in osteosarcoma by activating the Notch pathway.
  2. Specific intracellular retention of circSKA3 promotes colorectal cancer metastasis by attenuating ubiquitination and degradation of SLUG.
    Title: Specific intracellular retention of circSKA3 promotes colorectal cancer metastasis by attenuating ubiquitination and degradation of SLUG.
  3. Hypoxia-induced SKA3 promoted cholangiocarcinoma progression and chemoresistance by enhancing fatty acid synthesis via the regulation of PAR-dependent HIF-1a deubiquitylation.
    Title: Hypoxia-induced SKA3 promoted cholangiocarcinoma progression and chemoresistance by enhancing fatty acid synthesis via the regulation of PAR-dependent HIF-1a deubiquitylation.
  4. Transcription factor ZEB1 regulates PLK1-mediated SKA3 phosphorylation to promote lung cancer cell proliferation, migration and cell cycle.
    Title: Transcription factor ZEB1 regulates PLK1-mediated SKA3 phosphorylation to promote lung cancer cell proliferation, migration and cell cycle.
  5. SKA3 is a prognostic biomarker and associated with immune infiltration in bladder cancer.
    Title: SKA3 is a prognostic biomarker and associated with immune infiltration in bladder cancer.
  6. SKA3 promotes glioblastoma proliferation and invasion by enhancing the activation of Wnt/beta-catenin signaling via modulation of the Akt/GSK-3beta axis.
    Title: SKA3 promotes glioblastoma proliferation and invasion by enhancing the activation of Wnt/β-catenin signaling via modulation of the Akt/GSK-3β axis.
  7. MiR-133b suppresses the proliferation, migration and invasion of lung adenocarcinoma cells by targeting SKA3.
    Title: MiR-133b suppresses the proliferation, migration and invasion of lung adenocarcinoma cells by targeting SKA3.
  8. SKA3 Promotes Cell Growth in Breast Cancer by Inhibiting PLK-1 Protein Degradation.
    Title: SKA3 Promotes Cell Growth in Breast Cancer by Inhibiting PLK-1 Protein Degradation.
  9. Transcript levels of spindle and kinetochore-associated complex 1/3 as prognostic biomarkers correlated with immune infiltrates in hepatocellular carcinoma.
    Title: Transcript levels of spindle and kinetochore-associated complex 1/3 as prognostic biomarkers correlated with immune infiltrates in hepatocellular carcinoma.
  10. Circ-SKA3 Enhances Doxorubicin Toxicity in AC16 Cells Through miR-1303/TLR4 Axis.
    Title: Circ-SKA3 Enhances Doxorubicin Toxicity in AC16 Cells Through miR-1303/TLR4 Axis.
Submit: New GeneRIF Correction See all GeneRIFs (29)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC4832

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in attachment of mitotic spindle microtubules to kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in attachment of mitotic spindle microtubules to kinetochore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromosome segregation IEA
Inferred from Electronic Annotation
more info
  
involved_in establishment of meiotic spindle orientation IEA
Inferred from Electronic Annotation
more info
  
involved_in establishment of meiotic spindle orientation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in metaphase chromosome alignment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic metaphase chromosome alignment IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in mitotic sister chromatid segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of mitotic spindle assembly checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of microtubule polymerization or depolymerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in spindle assembly involved in female meiosis IEA
Inferred from Electronic Annotation
more info
  
involved_in spindle assembly involved in female meiosis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of SKA complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
located_in kinetochore IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in meiotic spindle IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
 PubMed 
part_of outer kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of outer kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
part_of outer kinetochore IEA
Inferred from Electronic Annotation
more info
  
located_in spindle IEA
Inferred from Electronic Annotation
more info
  
is_active_in spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
spindle and kinetochore-associated protein 3

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166017.2 → NP_001159489.1  spindle and kinetochore-associated protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001159489.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift and alternate stop codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AF361358, AK090584, AL158032
    Consensus CDS
    CCDS53856.1
    UniProtKB/Swiss-Prot
    Q8IX90
    Related
    ENSP00000382896.3, ENST00000400018.7
    Conserved Domains (1) summary
    cd12957
    Location:3 → 101
    SKA3_N; Spindle and kinetochore-associated protein 3, N-terminal domain

  2. NM_145061.6 → NP_659498.4  spindle and kinetochore-associated protein 3 isoform 1

    See identical proteins and their annotated locations for NP_659498.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF361358, AL158032
    Consensus CDS
    CCDS31946.1
    UniProtKB/Swiss-Prot
    A2A330, A2A331, B2RBY2, Q5VZV5, Q86WR2, Q8IX90, Q8NBG1, Q96D22
    Related
    ENSP00000319417.5, ENST00000314759.6
    Conserved Domains (1) summary
    cd12957
    Location:3 → 101
    SKA3_N; Spindle and kinetochore-associated protein 3, N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    21153595..21176552 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005266288.5 → XP_005266345.1  spindle and kinetochore-associated protein 3 isoform X2

    See identical proteins and their annotated locations for XP_005266345.1

    UniProtKB/Swiss-Prot
    Q8IX90
    Conserved Domains (1) summary
    cd12957
    Location:1 → 19
    SKA3_N; Spindle and kinetochore-associated protein 3, N-terminal domain

  2. XM_011534994.3 → XP_011533296.1  spindle and kinetochore-associated protein 3 isoform X1

    Conserved Domains (1) summary
    cd12957
    Location:1 → 61
    SKA3_N; Spindle and kinetochore-associated protein 3, N-terminal domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    20346668..20369632 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054374207.1 → XP_054230182.1  spindle and kinetochore-associated protein 3 isoform X2

  2. XM_054374206.1 → XP_054230181.1  spindle and kinetochore-associated protein 3 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IX90.2 GenPept UniProtKB/Swiss-Prot:Q8IX90

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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