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Tssk2 testis-specific serine kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 22115, updated on 8-Dec-2022

Summary

Official Symbol
Tssk2provided by MGI
Official Full Name
testis-specific serine kinase 2provided by MGI
Primary source
MGI:MGI:1347559
See related
Ensembl:ENSMUSG00000045521 AllianceGenome:MGI:1347559
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tsk2; DGS-G; SPOGA2; Stk22b
Summary
Enables magnesium ion binding activity and protein serine/threonine kinase activity. Involved in peptidyl-serine phosphorylation and spermatid development. Located in acrosomal vesicle and centriole. Is expressed in embryo; seminiferous tubule; spermatid; and testis. Orthologous to human TSSK2 (testis specific serine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See Tssk2 in Genome Data Viewer
Location:
16 A3; 16 11.09 cM
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (17716501..17717888)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (17898637..17900024)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene DiGeorge syndrome critical region gene 2 Neighboring gene testis-specific serine kinase 1 Neighboring gene ess-2 splicing factor Neighboring gene goosecoid homebox 2

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to glucose starvation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in spermatid development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in centriole IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
part_of nucleotide-activated protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
testis-specific serine/threonine-protein kinase 2
Names
TSK-2
TSSK-2
serine/threonine kinase 22B (spermiogenesis associated)
serine/threonine-protein kinase 22B
testis specific serine/ threonine kinase 2
testis-specific kinase 2
NP_033462.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009436.2NP_033462.2  testis-specific serine/threonine-protein kinase 2

    See identical proteins and their annotated locations for NP_033462.2

    Status: VALIDATED

    Source sequence(s)
    BC049618, BC061175, BY714760
    Consensus CDS
    CCDS28012.1
    UniProtKB/Swiss-Prot
    O54863, Q6P8M9
    Related
    ENSMUSP00000051035.7, ENSMUST00000055374.8
    Conserved Domains (2) summary
    smart00220
    Location:12272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14165
    Location:10272
    STKc_TSSK1_2-like; Catalytic domain of testis-specific serine/threonine kinase 1, TSSK2, and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    17716501..17717888
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)