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NSUN6 NOP2/Sun RNA methyltransferase 6 [ Homo sapiens (human) ]

Gene ID: 221078, updated on 24-Nov-2020

Summary

Official Symbol
NSUN6provided by HGNC
Official Full Name
NOP2/Sun RNA methyltransferase 6provided by HGNC
Primary source
HGNC:HGNC:23529
See related
Ensembl:ENSG00000241058 MIM:617199
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NOPD1; ARL5B-AS1; 4933414E04Rik
Expression
Ubiquitous expression in testis (RPKM 4.8), liver (RPKM 4.1) and 25 other tissues See more
Orthologs

Genomic context

See NSUN6 in Genome Data Viewer
Location:
10p12.31
Exon count:
19
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (18512582..18659264, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (18834264..18948180, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 39 member 12 Neighboring gene SLC39A12 antisense RNA 1 Neighboring gene calcium voltage-gated channel auxiliary subunit beta 2 Neighboring gene uncharacterized LOC107984213 Neighboring gene uncharacterized LOC105376440 Neighboring gene ADP ribosylation factor like GTPase 5B Neighboring gene AIFM1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23743, DKFZp686G10106

Gene Ontology Provided by GOA

Function Evidence Code Pubs
tRNA (cytosine-5-)-methyltransferase activity EXP
Inferred from Experiment
more info
PubMed 
tRNA (cytosine-5-)-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
tRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
RNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tRNA C5-cytosine methylation IDA
Inferred from Direct Assay
more info
PubMed 
tRNA methylation IDA
Inferred from Direct Assay
more info
PubMed 
tRNA modification TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
tRNA (cytosine(72)-C(5))-methyltransferase NSUN6
Names
ARL5B antisense RNA 1
NOL1/NOP2/Sun and PUA domain-containing protein 1
NOL1/NOP2/Sun domain family, member 6
NOP2/Sun RNA methyltransferase family member 6
NOP2/Sun domain family, member 6
nucleolar protein (NOL1/NOP2/sun) and PUA domains 1
putative methyltransferase NSUN6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001351115.2NP_001338044.1  tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AA347409, BC035778, DB012566, HY169016
    Conserved Domains (2) summary
    smart00359
    Location:114201
    PUA; Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase
    COG0144
    Location:214464
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]
  2. NM_001351116.2NP_001338045.1  tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL600949, BC035778
    Conserved Domains (2) summary
    smart00359
    Location:103190
    PUA; Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase
    COG0144
    Location:203453
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]
  3. NM_001351117.2NP_001338046.1  tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 isoform 4

    Status: VALIDATED

    Source sequence(s)
    BC035778, DB012566, HY169016
    Conserved Domains (2) summary
    smart00359
    Location:63150
    PUA; Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase
    COG0144
    Location:163413
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]
  4. NM_001351118.2NP_001338047.1  tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 isoform 5

    Status: VALIDATED

    Source sequence(s)
    BC035778, BQ224447, HY169016
    Conserved Domains (1) summary
    COG0144
    Location:74324
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]
  5. NM_182543.5NP_872349.1  tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 isoform 1

    See identical proteins and their annotated locations for NP_872349.1

    Status: VALIDATED

    Source sequence(s)
    BC035778, DB012566, HY169016
    Consensus CDS
    CCDS7130.1
    UniProtKB/Swiss-Prot
    Q8TEA1
    Related
    ENSP00000366519.4, ENST00000377304.7
    Conserved Domains (2) summary
    smart00359
    Location:115202
    PUA; Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase
    COG0144
    Location:215465
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    18512582..18659264 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447884.1XP_024303652.1  tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 isoform X3

    Conserved Domains (2) summary
    smart00359
    Location:103190
    PUA; Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase
    COG0144
    Location:203453
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]
  2. XM_017015913.2XP_016871402.1  tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 isoform X8

    Conserved Domains (1) summary
    COG0144
    Location:74324
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]
  3. XM_017015911.2XP_016871400.1  tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 isoform X6

    Conserved Domains (2) summary
    smart00359
    Location:16103
    PUA; Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase
    COG0144
    Location:116366
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]
  4. XM_017015910.2XP_016871399.1  tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 isoform X5

    Conserved Domains (2) summary
    smart00359
    Location:16107
    PUA; Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase
    COG0144
    Location:120370
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]
  5. XM_011519389.3XP_011517691.1  tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 isoform X7

    Conserved Domains (1) summary
    COG0144
    Location:78328
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]
  6. XM_017015912.2XP_016871401.1  tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 isoform X7

    Conserved Domains (1) summary
    COG0144
    Location:78328
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]
  7. XM_011519386.2XP_011517688.1  tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 isoform X2

    See identical proteins and their annotated locations for XP_011517688.1

    Conserved Domains (2) summary
    smart00359
    Location:103194
    PUA; Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase
    COG0144
    Location:207457
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]
  8. XM_011519385.1XP_011517687.1  tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 isoform X2

    See identical proteins and their annotated locations for XP_011517687.1

    Conserved Domains (2) summary
    smart00359
    Location:103194
    PUA; Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase
    COG0144
    Location:207457
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]
  9. XM_011519384.1XP_011517686.1  tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 isoform X2

    See identical proteins and their annotated locations for XP_011517686.1

    Conserved Domains (2) summary
    smart00359
    Location:103194
    PUA; Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase
    COG0144
    Location:207457
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]
  10. XM_017015907.2XP_016871396.1  tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 isoform X2

    Conserved Domains (2) summary
    smart00359
    Location:103194
    PUA; Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase
    COG0144
    Location:207457
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]
  11. XM_011519387.2XP_011517689.1  tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 isoform X4

    Conserved Domains (2) summary
    smart00359
    Location:63154
    PUA; Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase
    COG0144
    Location:167417
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]
  12. XM_011519383.1XP_011517685.1  tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 isoform X1

    Conserved Domains (2) summary
    smart00359
    Location:114205
    PUA; Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase
    COG0144
    Location:218468
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]

RNA

  1. XR_001747060.1 RNA Sequence

  2. XR_001747059.1 RNA Sequence

  3. XR_930471.2 RNA Sequence

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