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SLC39A12 solute carrier family 39 member 12 [ Homo sapiens (human) ]

Gene ID: 221074, updated on 23-Nov-2021

Summary

Official Symbol
SLC39A12provided by HGNC
Official Full Name
solute carrier family 39 member 12provided by HGNC
Primary source
HGNC:HGNC:20860
See related
Ensembl:ENSG00000148482 MIM:608734
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZIP12; ZIP-12; LZT-Hs8; bA570F3.1
Summary
Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A12 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Aug 2008]
Expression
Restricted expression toward brain (RPKM 9.2) See more
Orthologs
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Genomic context

See SLC39A12 in Genome Data Viewer
Location:
10p12.33
Exon count:
13
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (17951918..18043285)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (18240847..18332214)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984212 Neighboring gene transmembrane protein 236 Neighboring gene mannose receptor C-type 1 Neighboring gene microRNA 511 Neighboring gene SLC39A12 antisense RNA 1 Neighboring gene calcium voltage-gated channel auxiliary subunit beta 2 Neighboring gene uncharacterized LOC107984213 Neighboring gene NOP2/Sun RNA methyltransferase 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ30499, MGC43205, MGC51099

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables zinc ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular zinc ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of sprouting angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of microtubule polymerization IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
 
involved_in response to decreased oxygen levels IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in zinc ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular vesicle HDA PubMed 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc transporter ZIP12
Names
LIV-1 subfamily of ZIP zinc transporter 8
solute carrier family 39 (metal ion transporter), member 12
solute carrier family 39 (zinc transporter), member 12
zrt- and Irt-like protein 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145195.2NP_001138667.1  zinc transporter ZIP12 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001138667.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL360231, BC094700, DB469365
    Consensus CDS
    CCDS44362.1
    UniProtKB/Swiss-Prot
    Q504Y0
    Related
    ENSP00000366586.2, ENST00000377369.7
    Conserved Domains (1) summary
    pfam02535
    Location:369671
    Zip; ZIP Zinc transporter
  2. NM_001282733.2NP_001269662.1  zinc transporter ZIP12 isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the coding region compared to variant 1. The encoded isoform (3) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    BC035118, BC094700, BF963263, DB540352, DB545916
    Consensus CDS
    CCDS60493.1
    UniProtKB/Swiss-Prot
    Q504Y0
    Related
    ENSP00000366588.3, ENST00000377371.3
    Conserved Domains (1) summary
    pfam02535
    Location:369670
    Zip; ZIP Zinc transporter
  3. NM_001282734.2NP_001269663.1  zinc transporter ZIP12 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two exons and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AK295294, BC143551, BF963263, DB469365, DB540352, DB545916
    Consensus CDS
    CCDS60494.1
    UniProtKB/Swiss-Prot
    Q504Y0
    Related
    ENSP00000440445.1, ENST00000539911.5
    Conserved Domains (1) summary
    pfam02535
    Location:235537
    Zip; ZIP Zinc transporter
  4. NM_152725.4NP_689938.2  zinc transporter ZIP12 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region compared to variant 1. The encoded isoform (2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AK055061, AL360231, BC094700, DB469365
    Consensus CDS
    CCDS7124.1
    UniProtKB/Swiss-Prot
    Q504Y0
    Related
    ENSP00000366591.4, ENST00000377374.8
    Conserved Domains (1) summary
    pfam02535
    Location:369634
    Zip; ZIP Zinc transporter

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    17951918..18043285
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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