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FCGR1B Fc fragment of IgG receptor Ib [ Homo sapiens (human) ]

Gene ID: 2210, updated on 19-Jul-2021

Summary

Official Symbol
FCGR1Bprovided by HGNC
Official Full Name
Fc fragment of IgG receptor Ibprovided by HGNC
Primary source
HGNC:HGNC:3614
See related
Ensembl:ENSG00000198019 MIM:601502
Gene type
pseudo
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD34; FCG1; FcRI; CD64b; FCGR1; IGFR1; IGFRB; FcgammaRIa
Summary
Three distinct, but closely related classes of receptors that bind the Fc portion of IgG have been identified (Fcgamma RI, II and III). The FcgammaRI family consists of three closely related genes termed A, B, and C. This gene likely encodes a non-functional protein that is not detectable at the cell surface and binds ligand with low affinity. [provided by RefSeq, Nov 2019]
Expression
Biased expression in appendix (RPKM 11.2), placenta (RPKM 7.0) and 11 other tissues See more
Orthologs
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Genomic context

See FCGR1B in Genome Data Viewer
Location:
1p11.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (121087345..121097161)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (120926128..120935944, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene PDE4DIP pseudogene 4 Neighboring gene tRNA-Asn (anticodon GTT) 27-1 Neighboring gene ubiquitin-conjugating enzyme E2 D4 pseudogene Neighboring gene H3 histone pseudogene 4 Neighboring gene uncharacterized LOC100996318 Neighboring gene H2B histone pseudogene 1 Neighboring gene ribosomal protein L22 pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env IgG2 and IgG4 bind more poorly to enzymatically deglycosylated recombinant gp120 (rgp120) than to unchanged rgp120 PubMed
Nef nef HIV-1 Nef downregulates Fc-gamma Receptor I in human monocytes/macrophages PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Other Names

  • Fc fragment of IgG, high affinity Ib, receptor (CD64)
  • Fc gamma receptor Ib
  • Fc-gamma RI
  • Fc-gamma RIA
  • Fc-gamma receptor I B2
  • High affinity immunoglobulin gamma Fc receptor I
  • IgG Fc receptor I
  • fc-gamma RIB
  • fcRIB
  • hFcgammaRIB
  • high affinity immunoglobulin gamma Fc receptor IB
  • igG Fc receptor IB

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables IgG binding IEA
Inferred from Electronic Annotation
more info
 
enables immunoglobulin receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in Fc receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in immune response NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in clathrin-coated endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
located_in early endosome membrane TAS
Traceable Author Statement
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_045213.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an additional exon compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC244453
  2. NR_164758.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC244453
  3. NR_164759.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC244453
    Related
    ENST00000369384.9
  4. NR_164760.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC244453
    Related
    ENST00000623603.3

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    121087345..121097161
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_030319.1: Suppressed sequence

    Description
    NG_030319.1: This RefSeq was removed because it is now thought that this gene is a pseudogene.
  2. NM_001004340.4: Suppressed sequence

    Description
    NM_001004340.4: This RefSeq was removed because it is now thought that this gene is a pseudogene.
  3. NM_001017986.4: Suppressed sequence

    Description
    NM_001017986.4: This RefSeq was removed because it is now thought that this gene is a pseudogene.
  4. NM_001244910.1: Suppressed sequence

    Description
    NM_001244910.1: This RefSeq was removed because it is now thought that this gene is a pseudogene.
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