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FCGR1B Fc fragment of IgG receptor Ib [ Homo sapiens (human) ]

Gene ID: 2210, updated on 15-Jun-2019

Summary

Official Symbol
FCGR1Bprovided by HGNC
Official Full Name
Fc fragment of IgG receptor Ibprovided by HGNC
Primary source
HGNC:HGNC:3614
See related
Ensembl:ENSG00000198019 MIM:601502
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FCG1; FcRI; CD64b; FCGR1; IGFR1; IGFRB; FCGR1A; FcgammaRIa
Summary
Three distinct, but closely related classes of receptors that bind the Fc portion of IgG have been identified (Fcgamma RI, II and III). The FcgammaRI family consists of three closely related genes termed A, B, and C. This gene encodes the low affinity FcgammaRIB receptor that may play an important role in humoral immune response. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Expression
Biased expression in appendix (RPKM 11.2), placenta (RPKM 7.0) and 11 other tissues See more
Orthologs

Genomic context

See FCGR1B in Genome Data Viewer
Location:
1p11.2
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (121087345..121097161)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (120926128..120935944, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 4D interacting protein pseudogene Neighboring gene transfer RNA asparagine (anticodon GUU) Neighboring gene ubiquitin-conjugating enzyme E2 D4 pseudogene Neighboring gene uncharacterized LOC100996318 Neighboring gene histone cluster 2 H2B family member a (pseudogene) Neighboring gene histone cluster 2 H3 family member d pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env IgG2 and IgG4 bind more poorly to enzymatically deglycosylated recombinant gp120 (rgp120) than to unchanged rgp120 PubMed
Nef nef HIV-1 Nef downregulates Fc-gamma Receptor I in human monocytes/macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Antigen processing-Cross presentation, organism-specific biosystem (from REACTOME)
    Antigen processing-Cross presentation, organism-specific biosystemMHC class I molecules generally present peptide antigens derived from proteins synthesized by the cell itself to CD8+ T cells. However, in some circumstances, antigens from extracellular environment ...
  • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
    Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
  • Cross-presentation of soluble exogenous antigens (endosomes), organism-specific biosystem (from REACTOME)
    Cross-presentation of soluble exogenous antigens (endosomes), organism-specific biosystemExogenous soluble antigens are cross-presented by dendritic cells, albeit with lower efficiency than for particulate substrates. Soluble antigens destined for cross-presentation are taken up by disti...
  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Interferon Signaling, organism-specific biosystem (from REACTOME)
    Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
  • Interferon gamma signaling, organism-specific biosystem (from REACTOME)
    Interferon gamma signaling, organism-specific biosystemInterferon-gamma (IFN-gamma) belongs to the type II interferon family and is secreted by activated immune cells-primarily T and NK cells, but also B-cells and APC. INFG exerts its effect on cells by ...

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
IgG binding IEA
Inferred from Electronic Annotation
more info
 
immunoglobulin receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
Fc receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS
Traceable Author Statement
more info
 
immune response NAS
Non-traceable Author Statement
more info
PubMed 
interferon-gamma-mediated signaling pathway TAS
Traceable Author Statement
more info
 
receptor-mediated endocytosis TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
clathrin-coated endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
early endosome membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
high affinity immunoglobulin gamma Fc receptor IB
Names
Fc fragment of IgG, high affinity Ib, receptor (CD64)
Fc gamma receptor Ib
Fc-gamma RI
Fc-gamma RIA
Fc-gamma receptor I B2
High affinity immunoglobulin gamma Fc receptor I
IgG Fc receptor I
fc-gamma RIB
fcRIB
hFcgammaRIB
igG Fc receptor IB

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030319.1 RefSeqGene

    Range
    752..10568
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001004340.4NP_001004340.2  high affinity immunoglobulin gamma Fc receptor IB isoform 2 precursor

    See identical proteins and their annotated locations for NP_001004340.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as B2) lacks two consecutive in-frame coding exons compared to variant 1. This results in a shorter isoform (2) missing an internal protein segment compared to isoform 1.
    Source sequence(s)
    AC244453, AK307244, AW134502, BM992325, BQ030076, BU682943, L03419, L03420
    Consensus CDS
    CCDS72846.1
    UniProtKB/Swiss-Prot
    Q92637
    Related
    ENSP00000358390.4, ENST00000369383.8
    Conserved Domains (2) summary
    smart00410
    Location:1889
    IG_like; Immunoglobulin like
    cl11960
    Location:1691
    Ig; Immunoglobulin domain
  2. NM_001017986.4NP_001017986.2  high affinity immunoglobulin gamma Fc receptor IB isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as B1) encodes the longest isoform (1).
    Source sequence(s)
    AC244453
    Consensus CDS
    CCDS72845.1
    Related
    ENSP00000358391.4, ENST00000369384.8
  3. NM_001244910.1NP_001231839.1  high affinity immunoglobulin gamma Fc receptor IB isoform 3 precursor

    See identical proteins and their annotated locations for NP_001231839.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 3' terminal exon compared to variant 1. This results in a shorter isoform (3) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK307244, BC110416
    Consensus CDS
    CCDS72844.1
    UniProtKB/Swiss-Prot
    Q92637
    Related
    ENSP00000485498.1, ENST00000623603.3
    Conserved Domains (3) summary
    cd05752
    Location:22100
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:104183
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:28100
    IG_like; Immunoglobulin like

RNA

  1. NR_045213.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an additional exon compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC244453, AK307244, AW134502, BC110416, BM992325, BU682943

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    121087345..121097161
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017000661.1XP_016856150.1  high affinity immunoglobulin gamma Fc receptor IB isoform X1

  2. XM_017000662.1XP_016856151.1  high affinity immunoglobulin gamma Fc receptor IB isoform X2

RNA

  1. XR_001737040.1 RNA Sequence

  2. XR_002959729.1 RNA Sequence

  3. XR_001737041.2 RNA Sequence

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