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Tshr thyroid stimulating hormone receptor [ Mus musculus (house mouse) ]

Gene ID: 22095, updated on 15-Jan-2019

Summary

Official Symbol
Tshrprovided by MGI
Official Full Name
thyroid stimulating hormone receptorprovided by MGI
Primary source
MGI:MGI:98849
See related
Ensembl:ENSMUSG00000020963
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
hyt; pet; AI481368; hypothroid
Expression
Biased expression in subcutaneous fat pad adult (RPKM 19.7), genital fat pad adult (RPKM 11.8) and 3 other tissues See more
Orthologs

Genomic context

See Tshr in Genome Data Viewer
Location:
12 D3; 12 44.51 cM
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (91400993..91540509)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (92639433..92778949)

Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene centrosomal protein 128 Neighboring gene MOCO sulphurase C-terminal domain containing 2 pseudogene Neighboring gene transmembrane protein 126A pseudogene Neighboring gene phosphoglycerate mutase family member 5 pseudogene Neighboring gene predicted gene, 40541 Neighboring gene general transcription factor II A, 1 Neighboring gene stonin 2 Neighboring gene predicted gene, 16876

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (3) 
  • Targeted (1)  1 citation
  • Chemically induced (ENU) (1) 

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
protein-hormone receptor activity IEA
Inferred from Electronic Annotation
more info
 
signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
thyroid-stimulating hormone receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
thyroid-stimulating hormone receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
thyroid-stimulating hormone receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
activation of adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell surface receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
cellular response to glycoprotein ISO
Inferred from Sequence Orthology
more info
 
cellular response to thyrotropin-releasing hormone ISO
Inferred from Sequence Orthology
more info
 
cochlea morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
dopaminergic neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
hormone-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inner ear receptor cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
inner ear receptor cell stereocilium organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of adenylate cyclase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of locomotion IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
thyroid-stimulating hormone signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
thyrotropin receptor
Names
TSH-R

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113404.1NP_001106875.1  thyrotropin receptor isoform 2 precursor

    See identical proteins and their annotated locations for NP_001106875.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate exon in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 2) that has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK041086, BB645263
    Consensus CDS
    CCDS49135.1
    UniProtKB/TrEMBL
    Q78U67
    Related
    ENSMUSP00000021343.6, ENSMUST00000021343.7
    Conserved Domains (2) summary
    sd00033
    Location:5577
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13306
    Location:65221
    LRR_5; Leucine rich repeats (6 copies)
  2. NM_011648.5NP_035778.3  thyrotropin receptor isoform 1 precursor

    See identical proteins and their annotated locations for NP_035778.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BB645263, BC086691
    Consensus CDS
    CCDS26088.1
    UniProtKB/Swiss-Prot
    P47750
    Related
    ENSMUSP00000021346.7, ENSMUST00000021346.13
    Conserved Domains (4) summary
    pfam00001
    Location:437678
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam13855
    Location:76138
    LRR_8; Leucine rich repeat
    cl21587
    Location:417527
    7tm_2; 7 transmembrane receptor (Secretin family)
    sd00033
    Location:5477
    LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

    Range
    91400993..91540509
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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