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Tshb thyroid stimulating hormone, beta subunit [ Mus musculus (house mouse) ]

Gene ID: 22094, updated on 21-Aug-2024

Summary

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Official Symbol
Tshbprovided by MGI
Official Full Name
thyroid stimulating hormone, beta subunitprovided by MGI
Primary source
MGI:MGI:98848
See related
Ensembl:ENSMUSG00000027857 AllianceGenome:MGI:98848
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable hormone activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in cytoplasm. Is expressed in brain. Human ortholog(s) of this gene implicated in congenital nongoitrous hypothyroidism 4 and hypothyroidism. Orthologous to human TSHB (thyroid stimulating hormone subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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Location:
3 F2.2; 3 45.25 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (102684621..102718175, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (102777398..102789082, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3456 Neighboring gene predicted gene, 40112 Neighboring gene STARR-seq mESC enhancer starr_08578 Neighboring gene tetraspanin 2, opposite strand Neighboring gene tetraspanin 2 Neighboring gene STARR-seq mESC enhancer starr_08579 Neighboring gene STARR-positive B cell enhancer mm9_chr3:102608013-102608314 Neighboring gene synaptonemal complex protein 1 Neighboring gene STARR-seq mESC enhancer starr_08580 Neighboring gene predicted gene, 33866 Neighboring gene STARR-positive B cell enhancer ABC_E11206 Neighboring gene nuclear receptor subfamily 1, group H, member 5 Neighboring gene predicted gene, 22826

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Thyroid stimulating hormone β-subunit splice variant is expressed in all fractional subsets of bone marrow hematopoietic cells and peripheral blood leukocytes and is modulated during bacterial infection. Weber A, et al. Gen Comp Endocrinol, 2020 Aug 1. PMID 32360559, Free PMC Article
  2. Establishment of TSH β real-time monitoring system in mammalian photoperiodism. Tsujino K, et al. Genes Cells, 2013 Jul. PMID 23758111, Free PMC Article
  3. Bone marrow cells produce a novel TSHbeta splice variant that is upregulated in the thyroid following systemic virus infection. Vincent BH, et al. Genes Immun, 2009 Jan. PMID 18754015, Free PMC Article
  4. Virus infection activates thyroid stimulating hormone synthesis in intestinal epithelial cells. Varghese S, et al. J Cell Biochem, 2008 Sep 1. PMID 18523983, Free PMC Article
  5. Familial athyreotic cretinism: report of 3 cases. AINGER LE, et al. J Clin Endocrinol Metab, 1955 Apr. PMID 14367461

See all (198) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Thyroid stimulating hormone beta-subunit splice variant is expressed in all fractional subsets of bone marrow hematopoietic cells and peripheral blood leukocytes and is modulated during bacterial infection.
    Title: Thyroid stimulating hormone β-subunit splice variant is expressed in all fractional subsets of bone marrow hematopoietic cells and peripheral blood leukocytes and is modulated during bacterial infection.
  2. TSH, as an independent risk factor of atherosclerosis, aggravates vascular inflammation and contributes to atherogenesis.
    Title: Thyrotropin aggravates atherosclerosis by promoting macrophage inflammation in plaques.
  3. subcutaneous adipose tissue Tshb expression levels correlated directly with circulating cholesterol levels
    Title: TSHB mRNA is linked to cholesterol metabolism in adipose tissue.
  4. Oncogene-induced senescence is initiated in Braf(V600E)-induced papillary thyroid cancers when TSH is normal. TSH reduces p53 expression by upregulating the PI3K/AKT pathway and inhibiting OIS, resulting in tumor progression.
    Title: TSH overcomes Braf(V600E)-induced senescence to promote tumor progression via downregulation of p53 expression in papillary thyroid cancer.
  5. The observations indicate that the experimental system possesses responsiveness of the TSHbeta expression to melatonin.
    Title: Establishment of TSH β real-time monitoring system in mammalian photoperiodism.
  6. PPARalpha modulates the TSH beta-subunit mRNA expression in thyrotrope cells.
    Title: PPARα modulates the TSH β-subunit mRNA expression in thyrotrope TαT1 cells and in a mouse model.
  7. Tshb gene transcription was attenuated in MED1 mutant mice in which the nuclear receptor-binding ability of MED1 was specifically disrupted.
    Title: Mediator subunit MED1 is a T3-dependent and T3-independent coactivator on the thyrotropin β gene promoter.
  8. Disruption of type II deiodinase in thyrotrophs decreases their sensitivity to T4 thyroid hormone and thus elevates serum TSH.
    Title: Coordination of hypothalamic and pituitary T3 production regulates TSH expression.
  9. Thyrotropin-releasing hormone altered the basal expression of the TSHbeta gene and the responsiveness of the gene to thyroid hormone.
    Title: NR4A1 (Nur77) mediates thyrotropin-releasing hormone-induced stimulation of transcription of the thyrotropin β gene: analysis of TRH knockout mice.
  10. PBF is the first protein to interact with the critical TH transporter MCT8 and modulate its function in vivo
    Title: PTTG-binding factor (PBF) is a novel regulator of the thyroid hormone transporter MCT8.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • MGC151206, MGC151208

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hormone activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
thyrotropin subunit beta
Names
TSH-B
TSH-beta
thyroid-stimulating hormone subunit beta
thyrotropin beta chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001165939.1 → NP_001159411.1  thyrotropin subunit beta precursor

    See identical proteins and their annotated locations for NP_001159411.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC134871
    Consensus CDS
    CCDS17689.1
    UniProtKB/Swiss-Prot
    P12656
    UniProtKB/TrEMBL
    E9Q4F3, Q14AI3
    Related
    ENSMUSP00000128440.2, ENSMUST00000172026.8
    Conserved Domains (1) summary
    smart00068
    Location:20 → 126
    GHB; Glycoprotein hormone beta chain homologues

  2. NM_001165940.1 → NP_001159412.1  thyrotropin subunit beta precursor

    See identical proteins and their annotated locations for NP_001159412.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein. An in-frame AUG is located 17 codons upstream of the annotated translation start site but is not being annotated as a start site since it would disrupt the signal peptide on NP_001159412.1.
    Source sequence(s)
    AC134871
    Consensus CDS
    CCDS17689.1
    UniProtKB/Swiss-Prot
    P12656
    UniProtKB/TrEMBL
    E9Q4F3, Q14AI3
    Related
    ENSMUSP00000127165.2, ENSMUST00000170856.6
    Conserved Domains (1) summary
    smart00068
    Location:20 → 126
    GHB; Glycoprotein hormone beta chain homologues

  3. NM_009432.2 → NP_033458.2  thyrotropin subunit beta precursor

    See identical proteins and their annotated locations for NP_033458.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC134871
    Consensus CDS
    CCDS17689.1
    UniProtKB/Swiss-Prot
    P12656
    UniProtKB/TrEMBL
    E9Q4F3, Q14AI3
    Related
    ENSMUSP00000029450.4, ENSMUST00000029450.10
    Conserved Domains (1) summary
    smart00068
    Location:20 → 126
    GHB; Glycoprotein hormone beta chain homologues

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    102684621..102718175 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501305.5 → XP_006501368.1  thyrotropin subunit beta isoform X1

    See identical proteins and their annotated locations for XP_006501368.1

    UniProtKB/Swiss-Prot
    P12656
    UniProtKB/TrEMBL
    E9Q4F3, Q14AI3
    Conserved Domains (1) summary
    smart00068
    Location:20 → 126
    GHB; Glycoprotein hormone beta chain homologues

  2. XM_006501304.5 → XP_006501367.1  thyrotropin subunit beta isoform X1

    See identical proteins and their annotated locations for XP_006501367.1

    UniProtKB/Swiss-Prot
    P12656
    UniProtKB/TrEMBL
    E9Q4F3, Q14AI3
    Conserved Domains (1) summary
    smart00068
    Location:20 → 126
    GHB; Glycoprotein hormone beta chain homologues

  3. XM_036163022.1 → XP_036018915.1  thyrotropin subunit beta isoform X1

    UniProtKB/Swiss-Prot
    P12656
    UniProtKB/TrEMBL
    E9Q4F3, Q14AI3
    Conserved Domains (1) summary
    smart00068
    Location:20 → 126
    GHB; Glycoprotein hormone beta chain homologues

  4. XM_017319535.3 → XP_017175024.1  thyrotropin subunit beta isoform X1

    UniProtKB/Swiss-Prot
    P12656
    UniProtKB/TrEMBL
    E9Q4F3, Q14AI3
    Conserved Domains (1) summary
    smart00068
    Location:20 → 126
    GHB; Glycoprotein hormone beta chain homologues
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P12656.1 GenPept UniProtKB/Swiss-Prot:P12656

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