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Tsg101 tumor susceptibility gene 101 [ Mus musculus (house mouse) ]

Gene ID: 22088, updated on 18-Apr-2024

Summary

Official Symbol
Tsg101provided by MGI
Official Full Name
tumor susceptibility gene 101provided by MGI
Primary source
MGI:MGI:106581
See related
Ensembl:ENSMUSG00000014402 AllianceGenome:MGI:106581
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CC2
Summary
Enables transcription corepressor activity. Involved in exosomal secretion; positive regulation of ubiquitin-dependent endocytosis; and viral budding. Acts upstream of or within several processes, including keratinocyte differentiation; negative regulation of transcription by RNA polymerase II; and regulation of cell growth. Located in cytoplasm and extracellular exosome. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; limb; and nervous system. Human ortholog(s) of this gene implicated in breast cancer; breast carcinoma; cervix carcinoma; endometrial adenocarcinoma; and prostate cancer. Orthologous to human TSG101 (tumor susceptibility 101). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 29.9), CNS E14 (RPKM 28.1) and 28 other tissues See more
Orthologs
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Genomic context

Location:
7 B3; 7 30.62 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (46538693..46569716, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (46888949..46926320, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene lactate dehydrogenase A Neighboring gene predicted gene, 39011 Neighboring gene lactate dehydrogenase C Neighboring gene STARR-seq mESC enhancer starr_18876 Neighboring gene UEV and lactate/malate dehyrogenase domains Neighboring gene predicted gene, 39012 Neighboring gene thymosin, beta 10 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables virion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in endosome to lysosome transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in endosome to lysosome transport ISO
Inferred from Sequence Orthology
more info
 
involved_in exosomal secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in extracellular transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within keratinocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of epidermal growth factor-activated receptor activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of exosomal secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ubiquitin-dependent endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of viral budding via host ESCRT complex ISO
Inferred from Sequence Orthology
more info
 
involved_in protein modification process IEA
Inferred from Electronic Annotation
more info
 
involved_in protein monoubiquitination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of extracellular exosome assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in viral budding IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in viral budding ISO
Inferred from Sequence Orthology
more info
 
involved_in viral release from host cell ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of ESCRT I complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of ESCRT I complex ISO
Inferred from Sequence Orthology
more info
 
part_of ESCRT I complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
located_in late endosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IC
Inferred by Curator
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tumor susceptibility gene 101 protein
Names
ESCRT-I complex subunit TSG101

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348088.2NP_001335017.1  tumor susceptibility gene 101 protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate exons in the coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
    Source sequence(s)
    AC090123
    UniProtKB/TrEMBL
    Q3UK08
    Conserved Domains (3) summary
    TIGR02168
    Location:189331
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam05743
    Location:21139
    UEV; UEV domain
    pfam09454
    Location:264323
    Vps23_core; Vps23 core domain
  2. NM_001348089.2NP_001335018.1  tumor susceptibility gene 101 protein isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' region and uses a downstream start codon compared to variant 1. It encodes isoform 3 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC090123
    UniProtKB/TrEMBL
    A0A1B0GS09
    Conserved Domains (3) summary
    TIGR02168
    Location:148290
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam09454
    Location:223282
    Vps23_core; Vps23 core domain
    cl00154
    Location:145
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  3. NM_001417440.1NP_001404369.1  tumor susceptibility gene 101 protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC090123
  4. NM_021884.5NP_068684.1  tumor susceptibility gene 101 protein isoform 1

    See identical proteins and their annotated locations for NP_068684.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC090123
    Consensus CDS
    CCDS21291.1
    UniProtKB/Swiss-Prot
    Q61187
    UniProtKB/TrEMBL
    Q3UCW0, Q3UK08
    Related
    ENSMUSP00000014546.9, ENSMUST00000014546.15
    Conserved Domains (3) summary
    TIGR02168
    Location:242384
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam05743
    Location:21139
    UEV; UEV domain
    pfam09454
    Location:317376
    Vps23_core; Vps23 core domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    46538693..46569716 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242362.2XP_030098222.1  tumor susceptibility gene 101 protein isoform X1

    UniProtKB/TrEMBL
    A0A1B0GS09
    Related
    ENSMUSP00000147748.2, ENSMUST00000209538.2
    Conserved Domains (3) summary
    TIGR02168
    Location:95237
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam09454
    Location:170229
    Vps23_core; Vps23 core domain
    cl00154
    Location:145
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...