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CBWD5 COBW domain containing 5 [ Homo sapiens (human) ]

Gene ID: 220869, updated on 5-Jan-2022

Summary

Official Symbol
CBWD5provided by HGNC
Official Full Name
COBW domain containing 5provided by HGNC
Primary source
HGNC:HGNC:24584
See related
Ensembl:ENSG00000147996
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DC36; CBWD3
Summary
Predicted to enable ATP binding activity. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in thyroid (RPKM 9.8), small intestine (RPKM 9.4) and 25 other tissues See more
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Genomic context

See CBWD5 in Genome Data Viewer
Location:
9q21.11
Exon count:
23
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (65666374..65734041)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (70432004..70490211, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379447 Neighboring gene uncharacterized LOC105379251 Neighboring gene uncharacterized LOC105379250 Neighboring gene forkhead box D4 like 4 Neighboring gene immunoglobulin kappa variable 1/OR-3 (pseudogene)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ34856, FLJ40320, FLJ77192, MGC44166, MGC167043

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
COBW domain-containing protein 5
Names
COBW domain-containing protein 3
COBW-like placental protein
Cobalamin synthase W domain-containing protein 3
cobalamin synthase W domain-containing protein 5
cobalamin synthetase W domain-containing protein 5
dopamine responsive protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024916.4NP_001020087.2  COBW domain-containing protein 5 isoform a

    Status: VALIDATED

    Source sequence(s)
    BX284632
    Consensus CDS
    CCDS75841.1
    UniProtKB/TrEMBL
    O60748
    Related
    ENSP00000366612.4, ENST00000377395.8
    Conserved Domains (3) summary
    COG0523
    Location:42328
    YejR; GTPase, G3E family [General function prediction only]
    pfam07683
    Location:226325
    CobW_C; Cobalamin synthesis protein cobW C-terminal domain
    cl21455
    Location:43181
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. NM_001286835.2NP_001273764.1  COBW domain-containing protein 5 isoform b

    Status: VALIDATED

    Source sequence(s)
    BX284632
    Consensus CDS
    CCDS75844.1
    UniProtKB/TrEMBL
    Q5RIB3, Q6NVZ8
    Related
    ENSP00000366609.6, ENST00000377392.9
    Conserved Domains (1) summary
    pfam07683
    Location:55154
    CobW_C; Cobalamin synthesis protein cobW C-terminal domain
  3. NM_001286836.2NP_001273765.1  COBW domain-containing protein 5 isoform c

    See identical proteins and their annotated locations for NP_001273765.1

    Status: VALIDATED

    Source sequence(s)
    BX284632
    Consensus CDS
    CCDS75843.1
    UniProtKB/TrEMBL
    Q5RIB5, Q9H2J8
    Related
    ENSP00000366601.1, ENST00000377384.5
    Conserved Domains (1) summary
    cl21455
    Location:43112
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  4. NM_001330668.2NP_001317597.1  COBW domain-containing protein 5 isoform d

    Status: VALIDATED

    Source sequence(s)
    BX284632
    Consensus CDS
    CCDS83367.1
    UniProtKB/Swiss-Prot
    Q5RIA9
    Related
    ENSP00000371842.3, ENST00000382405.8
  5. NM_001363751.1NP_001350680.1  COBW domain-containing protein 5 isoform e

    Status: VALIDATED

    Source sequence(s)
    BX284632
    Consensus CDS
    CCDS87654.1
    Related
    ENSP00000397999.2, ENST00000430059.6
    Conserved Domains (2) summary
    COG0523
    Location:42357
    YejR; GTPase, G3E family [General function prediction only]
    cl26601
    Location:1962
    ABC_ATPase; Predicted ATPase of the ABC class

RNA

  1. NR_104600.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BX284632

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    65666374..65734041
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017014456.1XP_016869945.1  COBW domain-containing protein 5 isoform X6

    Conserved Domains (1) summary
    cl26870
    Location:1253
    CobW_C; Cobalamin synthesis protein cobW C-terminal domain
  2. XM_017014457.1XP_016869946.1  COBW domain-containing protein 5 isoform X7

  3. XM_024447453.1XP_024303221.1  COBW domain-containing protein 5 isoform X6

    Conserved Domains (1) summary
    cl26870
    Location:1253
    CobW_C; Cobalamin synthesis protein cobW C-terminal domain
  4. XM_006716914.1XP_006716977.1  COBW domain-containing protein 5 isoform X4

    Conserved Domains (2) summary
    COG0523
    Location:42317
    YejR; GTPase, G3E family [General function prediction only]
    cl21455
    Location:43207
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  5. XM_005272751.1XP_005272808.1  COBW domain-containing protein 5 isoform X3

    Conserved Domains (3) summary
    COG0523
    Location:42347
    YejR; GTPase, G3E family [General function prediction only]
    pfam07683
    Location:245344
    CobW_C; Cobalamin synthesis protein cobW C-terminal domain
    cl21455
    Location:43181
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  6. XM_017014455.1XP_016869944.1  COBW domain-containing protein 5 isoform X5

  7. XM_005272750.1XP_005272807.1  COBW domain-containing protein 5 isoform X2

    See identical proteins and their annotated locations for XP_005272807.1

    UniProtKB/Swiss-Prot
    Q5JTY5
    UniProtKB/TrEMBL
    A0A0A6YYH9
    Related
    ENSP00000405076.2, ENST00000429800.6
    Conserved Domains (3) summary
    COG0523
    Location:42356
    YejR; GTPase, G3E family [General function prediction only]
    pfam02492
    Location:43211
    cobW; CobW/HypB/UreG, nucleotide-binding domain
    pfam07683
    Location:254353
    CobW_C; Cobalamin synthesis protein cobW C-terminal domain
  8. XM_017014458.1XP_016869947.1  COBW domain-containing protein 5 isoform X8

  9. XM_017014459.1XP_016869948.1  COBW domain-containing protein 5 isoform X9

    Conserved Domains (2) summary
    pfam07683
    Location:106205
    CobW_C; Cobalamin synthesis protein cobW C-terminal domain
    cl21455
    Location:2063
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  10. XM_017014461.1XP_016869950.1  COBW domain-containing protein 5 isoform X10

RNA

  1. XR_428504.1 RNA Sequence

  2. XR_002956768.1 RNA Sequence

  3. XR_002956769.1 RNA Sequence

  4. XR_001746237.2 RNA Sequence

  5. XR_001746231.1 RNA Sequence

  6. XR_001746232.1 RNA Sequence

  7. XR_001746235.1 RNA Sequence

  8. XR_001746234.1 RNA Sequence

  9. XR_002956767.1 RNA Sequence

  10. XR_001746233.1 RNA Sequence

  11. XR_002956766.1 RNA Sequence

  12. XR_001746239.1 RNA Sequence

  13. XR_001746238.1 RNA Sequence

  14. XR_428503.2 RNA Sequence

  15. XR_001746240.1 RNA Sequence

  16. XR_001746241.2 RNA Sequence

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