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Tsc2 TSC complex subunit 2 [ Mus musculus (house mouse) ]

Gene ID: 22084, updated on 15-May-2022

Summary

Official Symbol
Tsc2provided by MGI
Official Full Name
TSC complex subunit 2provided by MGI
Primary source
MGI:MGI:102548
See related
Ensembl:ENSMUSG00000002496 AllianceGenome:MGI:102548
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tcs2; Nafld
Summary
Enables 14-3-3 protein binding activity. Involved in several processes, including anoikis; chemical synaptic transmission; and negative regulation of TORC1 signaling. Acts upstream of or within several processes, including intracellular protein transport; intracellular signal transduction; and negative regulation of intracellular signal transduction. Located in cytoplasm. Is active in synapse. Is expressed in several structures, including aorta; central nervous system; genitourinary system; hemolymphoid system gland; and retina. Used to study autism spectrum disorder; tuberous sclerosis; and uterine fibroid. Human ortholog(s) of this gene implicated in hepatic angiomyolipoma; lymphangioleiomyomatosis; medulloblastoma; tuberous sclerosis; and tuberous sclerosis 2. Orthologous to human TSC2 (TSC complex subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 31.9), ovary adult (RPKM 27.3) and 28 other tissues See more
Orthologs
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Genomic context

See Tsc2 in Genome Data Viewer
Location:
17 A3.3; 17 12.41 cM
Exon count:
42
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24814790..24851607, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24595816..24632676, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (24732882..24769574, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33508 Neighboring gene uncharacterized LOC115488769 Neighboring gene polycystin 1, transient receptor potential channel interacting Neighboring gene nth (endonuclease III)-like 1 (E.coli) Neighboring gene solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 14-3-3 protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables Hsp90 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein N-terminus binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in aging ISO
Inferred from Sequence Orthology
more info
 
involved_in anoikis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in anoikis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell projection organization ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within cellular response to insulin stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of cell polarity ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of protein localization ISO
Inferred from Sequence Orthology
more info
 
involved_in excitatory chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glucose import IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inhibitory chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within insulin-like growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within insulin-like growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of TOR signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of TOR signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of axonogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cell size ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in negative regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of macroautophagy ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of pinocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein kinase B signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of protein kinase B signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vascular endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neural tube closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within phosphatidylinositol 3-kinase signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dendritic spine development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fibroblast migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of macroautophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of macroautophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of macroautophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein kinase B signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein localization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport into plasma membrane raft IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of postsynapse organization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in social behavior ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of TSC1-TSC2 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of TSC1-TSC2 complex ISO
Inferred from Sequence Orthology
more info
 
located_in caveola ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tuberin
Names
tuberous sclerosis 2 protein homolog

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039363.3NP_001034452.1  tuberin isoform 2

    See identical proteins and their annotated locations for NP_001034452.1

    Status: VALIDATED

    Source sequence(s)
    AC132367
    Consensus CDS
    CCDS28486.1
    UniProtKB/TrEMBL
    Q3UGI8, Q7TT21
    Related
    ENSMUSP00000094986.2, ENSMUST00000097373.2
    Conserved Domains (3) summary
    pfam02145
    Location:14981684
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:555903
    Tuberin
    pfam11864
    Location:54419
    DUF3384; Domain of unknown function (DUF3384)
  2. NM_001286713.2NP_001273642.1  tuberin isoform 3

    See identical proteins and their annotated locations for NP_001273642.1

    Status: VALIDATED

    Source sequence(s)
    AC132367
    Consensus CDS
    CCDS89010.1
    UniProtKB/TrEMBL
    Q3UGI8, Q3UHB2
    Related
    ENSMUSP00000154338.2, ENSMUST00000227745.2
    Conserved Domains (3) summary
    pfam02145
    Location:15641750
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:555903
    Tuberin
    pfam11864
    Location:54469
    DUF3384; Domain of unknown function (DUF3384)
  3. NM_001286714.2NP_001273643.1  tuberin isoform 1

    See identical proteins and their annotated locations for NP_001273643.1

    Status: VALIDATED

    Source sequence(s)
    AC132367
    Consensus CDS
    CCDS89009.1
    UniProtKB/TrEMBL
    Q3UG88, Q3UGI8, Q7TT21
    Conserved Domains (3) summary
    pfam02145
    Location:15411727
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:555903
    Tuberin; Tuberin
    pfam11864
    Location:54466
    DUF3384; Domain of unknown function (DUF3384)
  4. NM_001286716.2NP_001273645.1  tuberin isoform 2

    See identical proteins and their annotated locations for NP_001273645.1

    Status: VALIDATED

    Source sequence(s)
    AC132367
    Consensus CDS
    CCDS28486.1
    UniProtKB/TrEMBL
    Q3UGI8, Q7TT21
    Related
    ENSMUSP00000153792.2, ENSMUST00000226398.2
    Conserved Domains (3) summary
    pfam02145
    Location:14981684
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:555903
    Tuberin
    pfam11864
    Location:54419
    DUF3384; Domain of unknown function (DUF3384)
  5. NM_001286718.2NP_001273647.1  tuberin isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC132367
    Consensus CDS
    CCDS89008.1
    UniProtKB/TrEMBL
    Q7TT21
    Related
    ENSMUSP00000154706.2, ENSMUST00000228412.2
    Conserved Domains (3) summary
    pfam02145
    Location:14971683
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:555903
    Tuberin; Tuberin
    pfam11864
    Location:54466
    DUF3384; Domain of unknown function (DUF3384)
  6. NM_001286720.2NP_001273649.1  tuberin isoform 5

    See identical proteins and their annotated locations for NP_001273649.1

    Status: VALIDATED

    Source sequence(s)
    AC132367
    UniProtKB/TrEMBL
    Q3TQ10, Q3UGI8, Q3UHB2
    Conserved Domains (3) summary
    pfam02145
    Location:15641756
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:555903
    Tuberin; Tuberin
    pfam11864
    Location:54466
    DUF3384; Domain of unknown function (DUF3384)
  7. NM_001403402.1NP_001390331.1  tuberin isoform 16

    Status: VALIDATED

    Source sequence(s)
    AC132367
  8. NM_001403403.1NP_001390332.1  tuberin isoform 17

    Status: VALIDATED

    Source sequence(s)
    AC132367
  9. NM_001403404.1NP_001390333.1  tuberin isoform 17

    Status: VALIDATED

    Source sequence(s)
    AC132367
  10. NM_001403405.1NP_001390334.1  tuberin isoform 16

    Status: VALIDATED

    Source sequence(s)
    AC132367
  11. NM_001403406.1NP_001390335.1  tuberin isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC132367
  12. NM_001403407.1NP_001390336.1  tuberin isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC132367
  13. NM_001403408.1NP_001390337.1  tuberin isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC132367
  14. NM_001403409.1NP_001390338.1  tuberin isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC132367
  15. NM_001403410.1NP_001390339.1  tuberin isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC132367
  16. NM_001403411.1NP_001390340.1  tuberin isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC132367
  17. NM_001403412.1NP_001390341.1  tuberin isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC132367
  18. NM_001403413.1NP_001390342.1  tuberin isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC132367
  19. NM_001403414.1NP_001390343.1  tuberin isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC132367
  20. NM_001403415.1NP_001390344.1  tuberin isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC132367
  21. NM_001403416.1NP_001390345.1  tuberin isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC132367
  22. NM_001403417.1NP_001390346.1  tuberin isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC132367
  23. NM_001403418.1NP_001390347.1  tuberin isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC132367
  24. NM_011647.4NP_035777.2  tuberin isoform 1

    See identical proteins and their annotated locations for NP_035777.2

    Status: VALIDATED

    Source sequence(s)
    AC132367
    Consensus CDS
    CCDS89009.1
    UniProtKB/TrEMBL
    Q3UGI8
    Related
    ENSMUSP00000153869.2, ENSMUST00000226284.2
    Conserved Domains (3) summary
    pfam02145
    Location:15411727
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:555903
    Tuberin; Tuberin
    pfam11864
    Location:54466
    DUF3384; Domain of unknown function (DUF3384)

RNA

  1. NR_175374.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC132367

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    24814790..24851607 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317392.2XP_017172881.1  tuberin isoform X13

    Conserved Domains (3) summary
    pfam02145
    Location:14961682
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:554902
    Tuberin
    pfam11864
    Location:54468
    DUF3384; Domain of unknown function (DUF3384)
  2. XM_036160478.1XP_036016371.1  tuberin isoform X9

    Conserved Domains (3) summary
    pfam02145
    Location:15191705
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:554902
    Tuberin
    pfam11864
    Location:54418
    DUF3384; Domain of unknown function (DUF3384)
  3. XM_006524044.3XP_006524107.1  tuberin isoform X12

    Conserved Domains (3) summary
    pfam02145
    Location:14971683
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:554902
    Tuberin
    pfam11864
    Location:54468
    DUF3384; Domain of unknown function (DUF3384)
  4. XM_036160477.1XP_036016370.1  tuberin isoform X8

    Conserved Domains (3) summary
    pfam02145
    Location:15201706
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:554902
    Tuberin
    pfam11864
    Location:54418
    DUF3384; Domain of unknown function (DUF3384)
  5. XM_036160476.1XP_036016369.1  tuberin isoform X5

    Conserved Domains (3) summary
    pfam02145
    Location:15391725
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:554902
    Tuberin
    pfam11864
    Location:54418
    DUF3384; Domain of unknown function (DUF3384)
  6. XM_006524040.3XP_006524103.1  tuberin isoform X4

    Conserved Domains (3) summary
    pfam02145
    Location:15401726
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:554902
    Tuberin
    pfam11864
    Location:54468
    DUF3384; Domain of unknown function (DUF3384)
  7. XM_017317386.2XP_017172875.1  tuberin isoform X2

    Conserved Domains (3) summary
    pfam02145
    Location:15631749
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:554902
    Tuberin
    pfam11864
    Location:54468
    DUF3384; Domain of unknown function (DUF3384)
  8. XM_017317389.3XP_017172878.1  tuberin isoform X7

    Conserved Domains (3) summary
    pfam02145
    Location:15201706
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:555903
    Tuberin
    pfam11864
    Location:54469
    DUF3384; Domain of unknown function (DUF3384)
  9. XM_017317388.3XP_017172877.1  tuberin isoform X6

    Conserved Domains (3) summary
    pfam02145
    Location:15211707
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:555903
    Tuberin
    pfam11864
    Location:54469
    DUF3384; Domain of unknown function (DUF3384)
  10. XM_017317387.3XP_017172876.1  tuberin isoform X3

    Conserved Domains (3) summary
    pfam02145
    Location:15401726
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:555903
    Tuberin
    pfam11864
    Location:54419
    DUF3384; Domain of unknown function (DUF3384)
  11. XM_017317385.3XP_017172874.1  tuberin isoform X1

    Conserved Domains (3) summary
    pfam02145
    Location:15631749
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:555903
    Tuberin
    pfam11864
    Location:54469
    DUF3384; Domain of unknown function (DUF3384)
  12. XM_017317384.3XP_017172873.1  tuberin isoform X19

    UniProtKB/TrEMBL
    Q3UHB2
    Conserved Domains (3) summary
    pfam02145
    Location:15641750
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:555903
    Tuberin
    pfam11864
    Location:54469
    DUF3384; Domain of unknown function (DUF3384)
  13. XM_030249651.2XP_030105511.1  tuberin isoform X11

    Conserved Domains (3) summary
    pfam02145
    Location:15041690
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:495843
    Tuberin
    pfam11864
    Location:1409
    DUF3384; Domain of unknown function (DUF3384)
  14. XM_036160482.1XP_036016375.1  tuberin isoform X17

    Conserved Domains (3) summary
    pfam02145
    Location:14381624
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:496844
    Tuberin
    pfam11864
    Location:1360
    DUF3384; Domain of unknown function (DUF3384)
  15. XM_036160481.1XP_036016374.1  tuberin isoform X15

    Conserved Domains (3) summary
    pfam02145
    Location:14611647
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:496844
    Tuberin
    pfam11864
    Location:1360
    DUF3384; Domain of unknown function (DUF3384)
  16. XM_017317393.2XP_017172882.1  tuberin isoform X16

    Related
    ENSMUSP00000153758.2, ENSMUST00000227607.2
    Conserved Domains (3) summary
    pfam02145
    Location:14391625
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:496844
    Tuberin
    pfam11864
    Location:1410
    DUF3384; Domain of unknown function (DUF3384)
  17. XM_017317391.2XP_017172880.1  tuberin isoform X10

    Conserved Domains (3) summary
    pfam02145
    Location:15051691
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:496844
    Tuberin
    pfam11864
    Location:1410
    DUF3384; Domain of unknown function (DUF3384)
  18. XM_030249647.2XP_030105507.1  tuberin isoform X10

    Conserved Domains (3) summary
    pfam02145
    Location:15051691
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:496844
    Tuberin
    pfam11864
    Location:1410
    DUF3384; Domain of unknown function (DUF3384)
  19. XM_036160475.1XP_036016368.1  tuberin isoform X3

    Conserved Domains (3) summary
    pfam02145
    Location:15401726
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:555903
    Tuberin
    pfam11864
    Location:54419
    DUF3384; Domain of unknown function (DUF3384)
  20. XM_030249646.2XP_030105506.1  tuberin isoform X2

    Conserved Domains (3) summary
    pfam02145
    Location:15631749
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:554902
    Tuberin
    pfam11864
    Location:54468
    DUF3384; Domain of unknown function (DUF3384)
  21. XM_036160480.1XP_036016373.1  tuberin isoform X14

    Conserved Domains (3) summary
    pfam02145
    Location:14821668
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:496844
    Tuberin
    pfam11864
    Location:1360
    DUF3384; Domain of unknown function (DUF3384)
  22. XM_036160479.1XP_036016372.1  tuberin isoform X14

    Conserved Domains (3) summary
    pfam02145
    Location:14821668
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:496844
    Tuberin
    pfam11864
    Location:1360
    DUF3384; Domain of unknown function (DUF3384)
  23. XM_017317390.2XP_017172879.1  tuberin isoform X10

    Conserved Domains (3) summary
    pfam02145
    Location:15051691
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:496844
    Tuberin
    pfam11864
    Location:1410
    DUF3384; Domain of unknown function (DUF3384)
  24. XM_036160483.1XP_036016376.1  tuberin isoform X18

    Conserved Domains (3) summary
    pfam02145
    Location:14381624
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:495843
    Tuberin
    pfam11864
    Location:1359
    DUF3384; Domain of unknown function (DUF3384)
  25. XM_030249650.2XP_030105510.1  tuberin isoform X11

    Conserved Domains (3) summary
    pfam02145
    Location:15041690
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:495843
    Tuberin
    pfam11864
    Location:1409
    DUF3384; Domain of unknown function (DUF3384)
  26. XM_030249648.1XP_030105508.1  tuberin isoform X10

    Conserved Domains (3) summary
    pfam02145
    Location:15051691
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:496844
    Tuberin
    pfam11864
    Location:1410
    DUF3384; Domain of unknown function (DUF3384)

RNA

  1. XR_004939509.1 RNA Sequence

  2. XR_003952103.2 RNA Sequence

  3. XR_001782062.3 RNA Sequence