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Trpc6 transient receptor potential cation channel, subfamily C, member 6 [ Mus musculus (house mouse) ]

Gene ID: 22068, updated on 27-Nov-2024

Summary

Official Symbol
Trpc6provided by MGI
Official Full Name
transient receptor potential cation channel, subfamily C, member 6provided by MGI
Primary source
MGI:MGI:109523
See related
Ensembl:ENSMUSG00000031997 AllianceGenome:MGI:109523
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TRP-6; Trrp6; mtrp6; LLHWJM002; LLHWJM003; LLHWJM004
Summary
Enables store-operated calcium channel activity. Acts upstream of or within positive regulation of cytosolic calcium ion concentration. Located in plasma membrane and slit diaphragm. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; liver and biliary system; and nervous system. Used to study focal segmental glomerulosclerosis 2. Human ortholog(s) of this gene implicated in chronic fatigue syndrome; focal segmental glomerulosclerosis; focal segmental glomerulosclerosis 2; and nephrotic syndrome type 2. Orthologous to human TRPC6 (transient receptor potential cation channel subfamily C member 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in lung adult (RPKM 2.0), frontal lobe adult (RPKM 1.1) and 15 other tissues See more
Orthologs
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Genomic context

See Trpc6 in Genome Data Viewer
Location:
9 A1; 9 2.46 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (8543868..8680753)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (8543867..8680752)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene U1-snRNP binding protein homolog pseudogene Neighboring gene microRNA 1899 Neighboring gene STARR-seq mESC enhancer starr_23245 Neighboring gene STARR-seq mESC enhancer starr_23246 Neighboring gene STARR-seq mESC enhancer starr_23247 Neighboring gene STARR-seq mESC enhancer starr_23248 Neighboring gene STARR-seq mESC enhancer starr_23249 Neighboring gene STARR-seq mESC enhancer starr_23250 Neighboring gene predicted gene, 32014 Neighboring gene STARR-seq mESC enhancer starr_23251 Neighboring gene STARR-seq mESC enhancer starr_23252 Neighboring gene STARR-seq mESC enhancer starr_23253 Neighboring gene STARR-seq mESC enhancer starr_23254 Neighboring gene STARR-seq mESC enhancer starr_23255 Neighboring gene STARR-seq mESC enhancer starr_23256 Neighboring gene progesterone receptor Neighboring gene STARR-seq mESC enhancer starr_23257 Neighboring gene Rho GTPase activating protein 42 Neighboring gene STARR-seq mESC enhancer starr_23258 Neighboring gene predicted gene, 16833

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
 
enables actin binding ISO
Inferred from Sequence Orthology
more info
 
enables actinin binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables clathrin binding ISO
Inferred from Sequence Orthology
more info
 
enables inositol 1,4,5 trisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables inositol 1,4,5 trisphosphate binding IEA
Inferred from Electronic Annotation
more info
 
enables inositol 1,4,5 trisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables monoatomic cation channel activity ISO
Inferred from Sequence Orthology
more info
 
enables monoatomic ion channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables store-operated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables store-operated calcium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of cation channel complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISA
Inferred from Sequence Alignment
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in slit diaphragm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
short transient receptor potential channel 6
Names
calcium entry channel
transient receptor protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282086.2NP_001269015.1  short transient receptor potential channel 6 isoform 2

    See identical proteins and their annotated locations for NP_001269015.1

    Status: VALIDATED

    Source sequence(s)
    AC155906, AC156791
    Consensus CDS
    CCDS90494.1
    UniProtKB/TrEMBL
    Q3UZG1
    Related
    ENSMUSP00000149686.2, ENSMUST00000214596.2
    Conserved Domains (4) summary
    cd00204
    Location:104238
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    TIGR00870
    Location:81818
    trp; transient-receptor-potential calcium channel protein
    pfam08344
    Location:252311
    TRP_2; Transient receptor ion channel II
    sd00045
    Location:131158
    ANK; ANK repeat [structural motif]
  2. NM_001282087.2NP_001269016.1  short transient receptor potential channel 6 isoform 3

    See identical proteins and their annotated locations for NP_001269016.1

    Status: VALIDATED

    Source sequence(s)
    AC155906
    Consensus CDS
    CCDS90495.1
    UniProtKB/TrEMBL
    Q6NV56
    Related
    ENSMUSP00000150193.2, ENSMUST00000217462.2
    Conserved Domains (5) summary
    cd00204
    Location:104238
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam08344
    Location:252311
    TRP_2; Transient receptor ion channel II
    pfam12796
    Location:136244
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:103152
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:131158
    ANK; ANK repeat [structural motif]
  3. NM_001429123.1NP_001416052.1  short transient receptor potential channel 6 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC155906, AC156791
    UniProtKB/Swiss-Prot
    B9EIW2, Q61143, Q9Z2J1
  4. NM_001429124.1NP_001416053.1  short transient receptor potential channel 6 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC155906, AC156791
  5. NM_001429125.1NP_001416054.1  short transient receptor potential channel 6 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC155906, AC156791
  6. NM_001429126.1NP_001416055.1  short transient receptor potential channel 6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC155906, AC156791
    UniProtKB/TrEMBL
    Q3UZG1
  7. NM_013838.3NP_038866.2  short transient receptor potential channel 6 isoform 1

    See identical proteins and their annotated locations for NP_038866.2

    Status: VALIDATED

    Source sequence(s)
    AC155906, AC156791
    Consensus CDS
    CCDS22815.1
    UniProtKB/Swiss-Prot
    B9EIW2, Q61143, Q9Z2J1
    Related
    ENSMUSP00000057965.7, ENSMUST00000050433.8
    Conserved Domains (2) summary
    TIGR00870
    Location:81896
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:131158
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    8543868..8680753
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242360.4XP_011240662.2  short transient receptor potential channel 6 isoform X4

    Conserved Domains (2) summary
    TIGR00870
    Location:131868
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:181208
    ANK; ANK repeat [structural motif]
  2. XM_006509850.4XP_006509913.1  short transient receptor potential channel 6 isoform X1

    See identical proteins and their annotated locations for XP_006509913.1

    UniProtKB/Swiss-Prot
    B9EIW2, Q61143, Q9Z2J1
    Conserved Domains (2) summary
    TIGR00870
    Location:81896
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:131158
    ANK; ANK repeat [structural motif]
  3. XM_011242359.3XP_011240661.1  short transient receptor potential channel 6 isoform X2

    Conserved Domains (2) summary
    TIGR00870
    Location:81868
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:131158
    ANK; ANK repeat [structural motif]
  4. XM_006509849.4XP_006509912.1  short transient receptor potential channel 6 isoform X3

    Conserved Domains (2) summary
    TIGR00870
    Location:100915
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:150177
    ANK; ANK repeat [structural motif]