Trpc4 transient receptor potential cation channel, subfamily C, member 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trpc4provided by MGI
Official Full Name: transient receptor potential cation channel, subfamily C, member 4provided by MGI
Primary source: MGI:MGI:109525
See related: Ensembl:ENSMUSG00000027748 AllianceGenome:MGI:109525
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CCE1; Trp4; Trrp4; STRPC4
Summary: Enables inositol 1,4,5 trisphosphate binding activity and store-operated calcium channel activity. Acts upstream of or within gamma-aminobutyric acid secretion and oligodendrocyte differentiation. Located in caveola. Part of protein-containing complex. Is expressed in several structures, including brain; cochlea; ganglia; genitourinary system; and liver. Orthologous to human TRPC4 (transient receptor potential cation channel subfamily C member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in frontal lobe adult (RPKM 2.6), CNS E18 (RPKM 2.6) and 10 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 3 C; 3 25.43 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (54063441..54225892)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (54155584..54318471)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hypothalamic warm-sensitive neurons require TRPC4 channel for detecting internal warmth and regulating body temperature in mice.
Title: Hypothalamic warm-sensitive neurons require TRPC4 channel for detecting internal warmth and regulating body temperature in mice.
TRPC4 and GIRK channels underlie neuronal coding of firing patterns that reflect Gq/11-Gi/o coincidence signals of variable strengths.
Title: TRPC4 and GIRK channels underlie neuronal coding of firing patterns that reflect G(q/11)-G(i/o) coincidence signals of variable strengths.
Sensory Neuron-Expressed TRPC4 Is a Target for the Relief of Psoriasiform Itch and Skin Inflammation in Mice.
Title: Sensory Neuron-Expressed TRPC4 Is a Target for the Relief of Psoriasiform Itch and Skin Inflammation in Mice.
Intracellular acidification facilitates receptor-operated TRPC4 activation through PLCdelta1 in a Ca(2+) -dependent manner.
Title: Intracellular acidification facilitates receptor-operated TRPC4 activation through PLCδ1 in a Ca(2+) -dependent manner.
Involvement of TRPC4 and 5 Channels in Persistent Firing in Hippocampal CA1 Pyramidal Cells.
Title: Involvement of TRPC4 and 5 Channels in Persistent Firing in Hippocampal CA1 Pyramidal Cells.
This study demonstrates that TRPC4 channels are involved in spontaneous and cholinergic-mediated contractions of the murine detrusor.
Title: Muscarinic receptor-induced contractions of the detrusor are impaired in TRPC4 deficient mice.
TRPC4 mediates itch and scratching behavior evoked by serotonergic antidepressants
Title: Peripheral serotonin receptor 2B and transient receptor potential channel 4 mediate pruritus to serotonergic antidepressants in mice.
analysis of mouse TRPC4 ion channel by cryoelectron microscopy reveals how its cytosolic N-terminal domain forms extensive aromatic contacts with the TRP and the C-terminal domains
Title: Structure of the mouse TRPC4 ion channel.
These results indicate the contribution of heteromultimeric channels from TRPC1, TRPC4, and TRPC5 subunits to the regulation of mechanisms underlying spatial working memory and flexible relearning by facilitating proper synaptic transmission in hippocampal neurons.
Title: Heteromeric channels formed by TRPC1, TRPC4 and TRPC5 define hippocampal synaptic transmission and working memory.
the antidepressant and anxiolytic-like effects of a newly identified TRPC4/C5 inhibitor, M084.
Title: Acute Treatment with a Novel TRPC4/C5 Channel Inhibitor Produces Antidepressant and Anxiolytic-Like Effects in Mice.

Submit: New GeneRIF Correction See all GeneRIFs (43)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (1)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

Trpc4 (e-PCR), detects polymorphism
- UniSTS:531241

D3Mit66 (e-PCR), detects polymorphism
- UniSTS:129834

Trrp4 (e-PCR), detects polymorphism
- UniSTS:144685

Trpc4 (e-PCR), detects polymorphism
- UniSTS:545840

Trpc4 (e-PCR), detects polymorphism
- UniSTS:516715

Trpc4 (e-PCR), detects polymorphism
- UniSTS:507345

Trpc4 (e-PCR), detects polymorphism
- UniSTS:507346

Homology

Homologs of the Trpc4 gene: The Trpc4 gene is conserved in human, chimpanzee, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, and frog.
Orthologs from Annotation Pipeline: 330 organisms have orthologs with human gene Trpc4
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables cadherin binding	ISO Inferred from Sequence Orthology more info
enables calcium channel activity	ISO Inferred from Sequence Orthology more info
enables inositol 1,4,5 trisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables inositol 1,4,5 trisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables store-operated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables store-operated calcium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in calcium ion import	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in calcium ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gamma-aminobutyric acid secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within oligodendrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of store-operated calcium entry	ISO Inferred from Sequence Orthology more info
involved_in regulation of action potential firing rate	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
part_of calcium channel complex	ISO Inferred from Sequence Orthology more info
part_of cation channel complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in caveola	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
colocalizes_with cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cortical cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: short transient receptor potential channel 4

Names: capacitative calcium entry channel Trp4; putative capacitative calcium entry channel; receptor-activated cation channel TRP4; transient receptor protein 4

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001253682.1 → NP_001240611.1 short transient receptor potential channel 4 isoform 2

See identical proteins and their annotated locations for NP_001240611.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame coding segment in the last exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AC117594, AK080670, CO043592

Consensus CDS

CCDS79904.1

UniProtKB/Swiss-Prot

Q9QUQ5

UniProtKB/TrEMBL

A0A6P7QQS5, A0A8C6MUP9, Q8BNT2

Related

ENSMUSP00000143593.2, ENSMUST00000200048.5

Conserved Domains (2) summary

TIGR00870
Location:17 → 749

trp; transient-receptor-potential calcium channel protein

sd00045
Location:122 → 167

ANK; ANK repeat [structural motif]
NM_001253683.1 → NP_001240612.1 short transient receptor potential channel 4 isoform 3

See identical proteins and their annotated locations for NP_001240612.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks several exons and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. It encodes isoform 3 which is shorter and has a distinct C-terminus compared to isoform 1.

Source sequence(s)

AC117594, AK080670, AK084139

UniProtKB/TrEMBL

Q8BNB6, Q8BNT2

Related

ENSMUST00000199399.5

Conserved Domains (4) summary

cd00204
Location:64 → 168

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam08344
Location:176 → 235

TRP_2; Transient receptor ion channel II

pfam12796
Location:39 → 168

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:122 → 167

ANK; ANK repeat [structural motif]
NM_016984.3 → NP_058680.1 short transient receptor potential channel 4 isoform 1

See identical proteins and their annotated locations for NP_058680.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC117594, AK080670, CO043592

Consensus CDS

CCDS17350.1

UniProtKB/Swiss-Prot

Q9QUQ5, Q9QZC0

UniProtKB/TrEMBL

A0A6P5PET9, Q0VB97, Q8BNT2

Related

ENSMUSP00000029311.7, ENSMUST00000029311.11

Conserved Domains (2) summary

TIGR00870
Location:17 → 749

trp; transient-receptor-potential calcium channel protein

sd00045
Location:122 → 167

ANK; ANK repeat [structural motif]

RNA

NR_046161.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses an alternate splice junction at the 3' end of an exon compared to variant 1, that causes a frameshift. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK080670, BC060160, CO043592

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

54063441..54225892

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017319534.3 → XP_017175023.1 short transient receptor potential channel 4 isoform X2

Conserved Domains (2) summary

TIGR00870
Location:17 → 749

trp; transient-receptor-potential calcium channel protein

sd00045
Location:122 → 167

ANK; ANK repeat [structural motif]
XM_006501298.3 → XP_006501361.1 short transient receptor potential channel 4 isoform X4

See identical proteins and their annotated locations for XP_006501361.1

UniProtKB/TrEMBL

A0A6P7QXB8

Conserved Domains (1) summary

TIGR00870
Location:1 → 329

trp; transient-receptor-potential calcium channel protein
XM_036163020.1 → XP_036018913.1 short transient receptor potential channel 4 isoform X4

UniProtKB/TrEMBL

A0A6P7QXB8

Conserved Domains (1) summary

TIGR00870
Location:1 → 329

trp; transient-receptor-potential calcium channel protein
XM_006501296.4 → XP_006501359.1 short transient receptor potential channel 4 isoform X1

See identical proteins and their annotated locations for XP_006501359.1

UniProtKB/Swiss-Prot

Q9QUQ5, Q9QZC0

UniProtKB/TrEMBL

A0A6P5PET9, Q0VB97

Conserved Domains (2) summary

TIGR00870
Location:17 → 749

trp; transient-receptor-potential calcium channel protein

sd00045
Location:122 → 167

ANK; ANK repeat [structural motif]
XM_006501297.5 → XP_006501360.1 short transient receptor potential channel 4 isoform X4

See identical proteins and their annotated locations for XP_006501360.1

UniProtKB/TrEMBL

A0A6P7QXB8

Conserved Domains (1) summary

TIGR00870
Location:1 → 329

trp; transient-receptor-potential calcium channel protein
XM_036163021.1 → XP_036018914.1 short transient receptor potential channel 4 isoform X4

UniProtKB/TrEMBL

A0A6P7QXB8

Conserved Domains (1) summary

TIGR00870
Location:1 → 329

trp; transient-receptor-potential calcium channel protein
XM_036163019.1 → XP_036018912.1 short transient receptor potential channel 4 isoform X3

Conserved Domains (1) summary

TIGR00870
Location:1 → 420

trp; transient-receptor-potential calcium channel protein