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Tob1 transducer of ErbB-2.1 [ Mus musculus (house mouse) ]

Gene ID: 22057, updated on 1-Mar-2024

Summary

Official Symbol
Tob1provided by MGI
Official Full Name
transducer of ErbB-2.1provided by MGI
Primary source
MGI:MGI:1349721
See related
Ensembl:ENSMUSG00000037573 AllianceGenome:MGI:1349721
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tob; Trob
Summary
Enables SMAD binding activity and transcription corepressor activity. Acts upstream of or within negative regulation of BMP signaling pathway; negative regulation of osteoblast differentiation; and regulation of SMAD protein signal transduction. Located in cytoplasm. Is expressed in 1st branchial arch; genitourinary system; limb; sensory organ; and skeleton. Orthologous to human TOB1 (transducer of ERBB2, 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal adult (RPKM 238.6), duodenum adult (RPKM 166.5) and 18 other tissues See more
Orthologs
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Genomic context

See Tob1 in Genome Data Viewer
Location:
11 D; 11 58.9 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (94100668..94106321)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (94209842..94215495)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene sperm associated antigen 9 Neighboring gene predicted gene, 38951 Neighboring gene STARR-positive B cell enhancer ABC_E10706 Neighboring gene RIKEN cDNA B230206L02 gene Neighboring gene STARR-seq mESC enhancer starr_30450 Neighboring gene STARR-seq mESC enhancer starr_30451 Neighboring gene predicted gene, 35338 Neighboring gene VISTA enhancer mm1496 Neighboring gene STARR-seq mESC enhancer starr_30458 Neighboring gene STARR-positive B cell enhancer mm9_chr11:94071474-94071775 Neighboring gene STARR-positive B cell enhancer ABC_E467 Neighboring gene STARR-seq mESC enhancer starr_30460 Neighboring gene WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_30462 Neighboring gene STARR-seq mESC enhancer starr_30463 Neighboring gene STARR-positive B cell enhancer ABC_E11487 Neighboring gene predicted gene, 38956

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SMAD binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of CCR4-NOT complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein Tob1
Names
transducer of erbB2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009427.2NP_033453.2  protein Tob1

    See identical proteins and their annotated locations for NP_033453.2

    Status: VALIDATED

    Source sequence(s)
    AL645846, CF748516
    Consensus CDS
    CCDS25250.1
    UniProtKB/Swiss-Prot
    Q61471, Q640M3
    UniProtKB/TrEMBL
    Q3UQ91
    Related
    ENSMUSP00000036039.6, ENSMUST00000041589.6
    Conserved Domains (1) summary
    smart00099
    Location:1106
    btg1; tob/btg1 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    94100668..94106321
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245921.1XP_030101781.1  protein Tob1 isoform X1

    UniProtKB/Swiss-Prot
    Q61471, Q640M3
    UniProtKB/TrEMBL
    Q3UQ91
    Conserved Domains (1) summary
    smart00099
    Location:1106
    btg1; tob/btg1 family