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RNF152 ring finger protein 152 [ Homo sapiens (human) ]

Gene ID: 220441, updated on 11-Sep-2019

Summary

Official Symbol
RNF152provided by HGNC
Official Full Name
ring finger protein 152provided by HGNC
Primary source
HGNC:HGNC:26811
See related
Ensembl:ENSG00000176641 MIM:616512
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in kidney (RPKM 29.4), liver (RPKM 4.9) and 13 other tissues See more
Orthologs

Genomic context

See RNF152 in Genome Data Viewer
Location:
18q21.33
Exon count:
6
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (61808067..61894420, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (59475300..59561634, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372157 Neighboring gene long intergenic non-protein coding RNA 1544 Neighboring gene uncharacterized LOC105372159 Neighboring gene uncharacterized LOC112268209 Neighboring gene ribose 5-phosphate isomerase A pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • E3 ubiquitin ligases ubiquitinate target proteins, organism-specific biosystem (from REACTOME)
    E3 ubiquitin ligases ubiquitinate target proteins, organism-specific biosystemE3 ubiquitin ligases catalyze the transfer of an ubiquitin from an E2-ubiquitin conjugate to a target protein. Generally, ubiquitin is transferred via formation of an amide bond to a particular lysin...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • Protein ubiquitination, organism-specific biosystem (from REACTOME)
    Protein ubiquitination, organism-specific biosystemUbiquitin is a small, 76 amino acid residue protein that is conjugated by E3 ubiquitin ligases to other proteins in order to regulate their function or degradation (enzymatic cascade reviewed in Neut...
  • mTOR signaling pathway, organism-specific biosystem (from KEGG)
    mTOR signaling pathway, organism-specific biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...
  • mTOR signaling pathway, conserved biosystem (from KEGG)
    mTOR signaling pathway, conserved biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ39176, MGC138161

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
small GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity EXP
Inferred from Experiment
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
apoptotic process TAS
Traceable Author Statement
more info
PubMed 
cellular response to amino acid starvation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to amino acid starvation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein K48-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein K48-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein K63-linked ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein ubiquitination TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
integral component of organelle membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
lysosomal membrane TAS
Traceable Author Statement
more info
 
lysosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase RNF152
Names
RING-type E3 ubiquitin transferase RNF152
NP_775828.1
XP_005266707.1
XP_005266709.1
XP_011524180.1
XP_011524181.1
XP_016881101.1
XP_016881102.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173557.3NP_775828.1  E3 ubiquitin-protein ligase RNF152

    See identical proteins and their annotated locations for NP_775828.1

    Status: VALIDATED

    Source sequence(s)
    AC105094, AK122758
    Consensus CDS
    CCDS11978.1
    UniProtKB/Swiss-Prot
    Q8N8N0
    Related
    ENSP00000316628.3, ENST00000312828.4
    Conserved Domains (1) summary
    cd16548
    Location:1155
    RING-HC_RNF152; RING finger, HC subclass, found in RING finger protein 152 (RNF152) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    61808067..61894420 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005266652.3XP_005266709.1  E3 ubiquitin-protein ligase RNF152 isoform X1

    See identical proteins and their annotated locations for XP_005266709.1

    UniProtKB/Swiss-Prot
    Q8N8N0
    Conserved Domains (1) summary
    cd16548
    Location:1155
    RING-HC_RNF152; RING finger, HC subclass, found in RING finger protein 152 (RNF152) and similar proteins
  2. XM_017025612.1XP_016881101.1  E3 ubiquitin-protein ligase RNF152 isoform X1

    UniProtKB/Swiss-Prot
    Q8N8N0
    Conserved Domains (1) summary
    cd16548
    Location:1155
    RING-HC_RNF152; RING finger, HC subclass, found in RING finger protein 152 (RNF152) and similar proteins
  3. XM_005266650.3XP_005266707.1  E3 ubiquitin-protein ligase RNF152 isoform X1

    See identical proteins and their annotated locations for XP_005266707.1

    UniProtKB/Swiss-Prot
    Q8N8N0
    Conserved Domains (1) summary
    cd16548
    Location:1155
    RING-HC_RNF152; RING finger, HC subclass, found in RING finger protein 152 (RNF152) and similar proteins
  4. XM_017025613.1XP_016881102.1  E3 ubiquitin-protein ligase RNF152 isoform X1

    UniProtKB/Swiss-Prot
    Q8N8N0
    Conserved Domains (1) summary
    cd16548
    Location:1155
    RING-HC_RNF152; RING finger, HC subclass, found in RING finger protein 152 (RNF152) and similar proteins
  5. XM_011525878.2XP_011524180.1  E3 ubiquitin-protein ligase RNF152 isoform X1

    See identical proteins and their annotated locations for XP_011524180.1

    UniProtKB/Swiss-Prot
    Q8N8N0
    Conserved Domains (1) summary
    cd16548
    Location:1155
    RING-HC_RNF152; RING finger, HC subclass, found in RING finger protein 152 (RNF152) and similar proteins
  6. XM_011525879.2XP_011524181.1  E3 ubiquitin-protein ligase RNF152 isoform X1

    See identical proteins and their annotated locations for XP_011524181.1

    UniProtKB/Swiss-Prot
    Q8N8N0
    Conserved Domains (1) summary
    cd16548
    Location:1155
    RING-HC_RNF152; RING finger, HC subclass, found in RING finger protein 152 (RNF152) and similar proteins
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