U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Plscr1 phospholipid scramblase 1 [ Mus musculus (house mouse) ]

Gene ID: 22038, updated on 6-Jun-2024

Summary

Official Symbol
Plscr1provided by MGI
Official Full Name
phospholipid scramblase 1provided by MGI
Primary source
MGI:MGI:893575
See related
Ensembl:ENSMUSG00000032369 AllianceGenome:MGI:893575
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nor1; Tra1; Tra1a; Tra1b; Tras1; Tras2; MmTRA1a; MmTRA1b
Summary
Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; metal ion binding activity; and signaling receptor binding activity. Involved in several processes, including negative regulation of viral genome replication; phosphatidylserine biosynthetic process; and response to interferon-alpha. Acts upstream of or within several processes, including cellular response to lipopolysaccharide; phosphatidylserine exposure on apoptotic cell surface; and positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage. Located in cytosol; nucleus; and plasma membrane. Is expressed in hindgut; midgut; renal calyx; and renal pelvis. Orthologous to human PLSCR1 (phospholipid scramblase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in colon adult (RPKM 25.8), large intestine adult (RPKM 18.1) and 22 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Plscr1 in Genome Data Viewer
Location:
9 E3.3; 9 48.35 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (92132265..92154034)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (92250194..92272561)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46147 Neighboring gene predicted gene, 31588 Neighboring gene phospholipid scramblase family, member 5 Neighboring gene predicted gene, 31531 Neighboring gene STARR-seq mESC enhancer starr_24896 Neighboring gene STARR-positive B cell enhancer mm9_chr9:92147733-92148034 Neighboring gene STARR-seq mESC enhancer starr_24897 Neighboring gene microRNA 6386 Neighboring gene phospholipid scramblase 2 Neighboring gene phospholipid scramblase 1 like 1 Neighboring gene predicted gene 15493

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables CD4 receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables epidermal growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables lead ion binding ISO
Inferred from Sequence Orthology
more info
 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables mercury ion binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables phospholipid scramblase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phospholipid scramblase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables virus receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in acute-phase response IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to cytokine stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in intrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within myeloid cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of viral genome replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphatidylserine biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphatidylserine exposure on apoptotic cell surface IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within phosphatidylserine exposure on apoptotic cell surface IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphatidylserine exposure on apoptotic cell surface IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in plasma membrane phospholipid scrambling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in plasma membrane phospholipid scrambling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of Fc receptor mediated stimulatory signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mast cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in response to interferon-alpha IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in collagen-containing extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
phospholipid scramblase 1
Names
PL scramblase 1
ca(2+)-dependent phospholipid scramblase 1
mg(2+)-dependent nuclease
transplantability-associated protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410453.1NP_001397382.1  phospholipid scramblase 1

    Status: VALIDATED

    Source sequence(s)
    AC111125
    UniProtKB/Swiss-Prot
    O54730, O54731, Q9D1F8, Q9JJ00
    UniProtKB/TrEMBL
    Q3UDV5
    Related
    ENSMUSP00000139479.2, ENSMUST00000186364.2
  2. NM_011636.3NP_035766.2  phospholipid scramblase 1

    See identical proteins and their annotated locations for NP_035766.2

    Status: VALIDATED

    Source sequence(s)
    AC111125
    Consensus CDS
    CCDS52886.1
    UniProtKB/Swiss-Prot
    O54730, O54731, Q9D1F8, Q9JJ00
    UniProtKB/TrEMBL
    Q3UDV5
    Related
    ENSMUSP00000091318.4, ENSMUST00000093801.10
    Conserved Domains (1) summary
    pfam03803
    Location:107316
    Scramblase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    92132265..92154034
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)