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Traf6 TNF receptor-associated factor 6 [ Mus musculus (house mouse) ]

Gene ID: 22034, updated on 15-Jul-2024

Summary

Official Symbol
Traf6provided by MGI
Official Full Name
TNF receptor-associated factor 6provided by MGI
Primary source
MGI:MGI:108072
See related
Ensembl:ENSMUSG00000027164 AllianceGenome:MGI:108072
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310003F17Rik; C630032O20Rik
Summary
This gene encodes a member of the TNF receptor associated factor (TRAF) family of adaptor proteins that mediate signaling events from members of the TNF receptor and Toll/IL-1 receptor families to activate transcription factors such as NF-kappa-B and AP-1. The product of this gene is essential for perinatal and postnatal survival. Mice deficient in this protein exhibit osteopetrosis and defective in development of epidermal appendixes, normal B cell differentiation, lymph node organogenesis, interleukin-1 signaling, lipopolysaccharide signaling and neural tube closure. This protein possesses ubiquitin ligase activity. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 2.0), thymus adult (RPKM 2.0) and 28 other tissues See more
Orthologs
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Genomic context

See Traf6 in Genome Data Viewer
Location:
2 E2; 2 53.9 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (101508765..101532013)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (101678420..101701668)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene recombination activating 1 Neighboring gene predicted gene, 34041 Neighboring gene STARR-positive B cell enhancer ABC_E5948 Neighboring gene STARR-positive B cell enhancer ABC_E5949 Neighboring gene proline rich 5 like Neighboring gene STARR-seq mESC enhancer starr_05236 Neighboring gene STARR-seq mESC enhancer starr_05237 Neighboring gene STARR-positive B cell enhancer ABC_E2043 Neighboring gene COMM domain containing 9

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (9)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase B binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables tumor necrosis factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin conjugating enzyme binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin protein ligase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables ubiquitin protein ligase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-ubiquitin ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
 
involved_in JNK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within T-helper 1 type immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in activation of NF-kappaB-inducing kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in activation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within animal organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in antiviral innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in autophagosome assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in bone remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in bone resorption IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to cytokine stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cytoplasmic pattern recognition receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in interleukin-1-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in interleukin-1-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in interleukin-17-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in interleukin-17-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in interleukin-17A-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in interleukin-33-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in lipopolysaccharide-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within myeloid dendritic cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in neural tube closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in non-canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within odontogenesis of dentin-containing tooth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of JUN kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell cytokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of interleukin-12 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-2 production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of leukocyte adhesion to vascular endothelial cell ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of lipopolysaccharide-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of type I interferon production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein K63-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein K63-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autoubiquitination TAS
Traceable Author Statement
more info
PubMed 
involved_in protein polyubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein ubiquitination IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of immunoglobulin production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in toll-like receptor 4 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in tumor necrosis factor-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of CD40 receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in extrinsic component of cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in lipid droplet IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of plasma membrane signaling receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
TNF receptor-associated factor 6
Names
E3 ubiquitin-protein ligase TRAF6
RING-type E3 ubiquitin transferase TRAF6
NP_001290202.1
NP_033450.2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303273.1NP_001290202.1  TNF receptor-associated factor 6

    See identical proteins and their annotated locations for NP_001290202.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL929571
    Consensus CDS
    CCDS16464.1
    UniProtKB/Swiss-Prot
    P70196, Q6P9M0, Q8BLV2
    Conserved Domains (4) summary
    cd00162
    Location:69107
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd03776
    Location:359508
    MATH_TRAF6; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF6 subfamily, TRAF domain, C-terminal MATH subdomain; composed of proteins with similarity to human TRAF6, including the Drosophila protein DTRAF2. TRAF molecules serve as adapter ...
    pfam02176
    Location:204261
    zf-TRAF; TRAF-type zinc finger
    cl01090
    Location:304356
    SlyX; SlyX
  2. NM_009424.3NP_033450.2  TNF receptor-associated factor 6

    See identical proteins and their annotated locations for NP_033450.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL929571, BC060705, BY131535
    Consensus CDS
    CCDS16464.1
    UniProtKB/Swiss-Prot
    P70196, Q6P9M0, Q8BLV2
    Related
    ENSMUSP00000004949.8, ENSMUST00000004949.8
    Conserved Domains (4) summary
    cd00162
    Location:69107
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd03776
    Location:359508
    MATH_TRAF6; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF6 subfamily, TRAF domain, C-terminal MATH subdomain; composed of proteins with similarity to human TRAF6, including the Drosophila protein DTRAF2. TRAF molecules serve as adapter ...
    pfam02176
    Location:204261
    zf-TRAF; TRAF-type zinc finger
    cl01090
    Location:304356
    SlyX; SlyX

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    101508765..101532013
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)