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Traf4 TNF receptor associated factor 4 [ Mus musculus (house mouse) ]

Gene ID: 22032, updated on 17-Nov-2020

Summary

Official Symbol
Traf4provided by MGI
Official Full Name
TNF receptor associated factor 4provided by MGI
Primary source
MGI:MGI:1202880
See related
Ensembl:ENSMUSG00000017386
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ms; CAR; msp2; CART1; A530032M13Rik
Expression
Ubiquitous expression in thymus adult (RPKM 49.0), whole brain E14.5 (RPKM 41.4) and 28 other tissues See more
Orthologs

Genomic context

See Traf4 in Genome Data Viewer
Location:
11; 11 B5
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (78049249..78056405, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (78158423..78165579, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (77971925..77979052, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC118567921 Neighboring gene Era (G-protein)-like 1 (E. coli) Neighboring gene family with sequence similarity 222, member B Neighboring gene U6 small nuclear RNA associated LSM6 pseudogene Neighboring gene NIMA (never in mitosis gene a)-related expressed kinase 8 Neighboring gene microRNA 7653 Neighboring gene TLC domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
WW domain binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
thioesterase binding ISO
Inferred from Sequence Orthology
more info
 
tumor necrosis factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
activation of NF-kappaB-inducing kinase activity IEA
Inferred from Electronic Annotation
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein K63-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
respiratory gaseous exchange by respiratory system IMP
Inferred from Mutant Phenotype
more info
PubMed 
respiratory tube development IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
tumor necrosis factor-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
bicellular tight junction IEA
Inferred from Electronic Annotation
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane signaling receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
TNF receptor-associated factor 4
Names
cysteine-rich motif associated to RING and Traf domains protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009423.4NP_033449.2  TNF receptor-associated factor 4

    See identical proteins and their annotated locations for NP_033449.2

    Status: VALIDATED

    Source sequence(s)
    AK040877, AK046015
    Consensus CDS
    CCDS25090.1
    UniProtKB/Swiss-Prot
    Q61382
    Related
    ENSMUSP00000017530.3, ENSMUST00000017530.3
    Conserved Domains (3) summary
    cd03781
    Location:308463
    MATH_TRAF4; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF4 subfamily, TRAF domain, C-terminal MATH subdomain; composed of proteins with similarity to human TRAF4, including the Drosophila protein DTRAF1. TRAF molecules serve as adapter ...
    pfam02176
    Location:210269
    zf-TRAF; TRAF-type zinc finger
    cd16641
    Location:1559
    mRING-HC-C3HC3D_TRAF4; Modified RING finger, HC subclass (C3HC3D-type), found in tumor necrosis factor (TNF) receptor-associated factor 4 (TRAF4) and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    78049249..78056405 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245920.1XP_030101780.1  TNF receptor-associated factor 4 isoform X1

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