U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Traf3 TNF receptor-associated factor 3 [ Mus musculus (house mouse) ]

Gene ID: 22031, updated on 27-Nov-2024

Summary

Official Symbol
Traf3provided by MGI
Official Full Name
TNF receptor-associated factor 3provided by MGI
Primary source
MGI:MGI:108041
See related
Ensembl:ENSMUSG00000021277 AllianceGenome:MGI:108041
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
amn; LAP1; CAP-1; CRAF1; T-BAM; CD40bp; TRAFAMN
Summary
Enables protein kinase binding activity. Involved in several processes, including regulation of defense response; regulation of gene expression; and tumor necrosis factor-mediated signaling pathway. Located in cytoplasmic side of plasma membrane. Part of CD40 receptor complex. Is expressed in several structures, including autopod; genitourinary system; hemolymphoid system gland; lower jaw epithelium; and mandibular process. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human TRAF3 (TNF receptor associated factor 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in spleen adult (RPKM 14.4), thymus adult (RPKM 12.7) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Traf3 in Genome Data Viewer
Location:
12 F1; 12 60.94 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (111132799..111233589)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (111166321..111267155)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:112276930-112277113 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:112277230-112277417 Neighboring gene STARR-positive B cell enhancer mm9_chr12:112283133-112283433 Neighboring gene predicted gene, 35846 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:112310033-112310280 Neighboring gene REST corepressor 1 Neighboring gene STARR-positive B cell enhancer ABC_E7184 Neighboring gene DNA repair protein SWI5 homolog pseudogene Neighboring gene VISTA enhancer mm3 Neighboring gene RIKEN cDNA 4930595D18 gene Neighboring gene STARR-positive B cell enhancer mm9_chr12:112398161-112398462 Neighboring gene STARR-positive B cell enhancer ABC_E7186 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:112477093-112477276 Neighboring gene RIKEN cDNA A230087F16 gene Neighboring gene predicted gene, 51960 Neighboring gene CDC42 binding protein kinase beta Neighboring gene amnionless

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (2) 
  • Endonuclease-mediated (3) 
  • Targeted (6)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase binding IEA
Inferred from Electronic Annotation
more info
 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables thioesterase binding IEA
Inferred from Electronic Annotation
more info
 
enables thioesterase binding ISO
Inferred from Sequence Orthology
more info
 
enables tumor necrosis factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables tumor necrosis factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in Toll signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of NF-kappaB transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of type I interferon production IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of type I interferon production ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of interferon-beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of proteolysis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in toll-like receptor 4 signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in toll-like receptor 4 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in toll-like receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in tumor necrosis factor-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in tumor necrosis factor-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of CD40 receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
part_of plasma membrane signaling receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
TNF receptor-associated factor 3
Names
CD40 receptor-associated factor 1
CD40-binding protein
RING-type E3 ubiquitin transferase TRAF3
NP_001273051.1
NP_001351293.1
NP_001409354.1
NP_001409355.1
NP_035762.2
XP_006515862.1
XP_006515863.1
XP_006515865.1
XP_030102544.1
XP_036013273.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286122.1NP_001273051.1  TNF receptor-associated factor 3 isoform b

    See identical proteins and their annotated locations for NP_001273051.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an internal exon in the 5' UTR and an in-frame exon in the coding region, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a.
    Source sequence(s)
    AC122023, AK147362, BF661650
    Consensus CDS
    CCDS36563.1
    UniProtKB/TrEMBL
    Q3UHJ1, Q3UHM2
    Related
    ENSMUSP00000112517.2, ENSMUST00000117269.8
    Conserved Domains (4) summary
    COG1196
    Location:226407
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd03777
    Location:352537
    MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam02176
    Location:135191
    zf-TRAF; TRAF-type zinc finger
    cd16640
    Location:5091
    RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins
  2. NM_001364364.1NP_001351293.1  TNF receptor-associated factor 3 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC122023, AC127580, AK147362, CJ127244
    Consensus CDS
    CCDS36563.1
    UniProtKB/TrEMBL
    Q3UHJ1, Q3UHM2
    Related
    ENSMUSP00000058361.7, ENSMUST00000060274.7
    Conserved Domains (4) summary
    COG1196
    Location:226407
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd03777
    Location:352537
    MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam02176
    Location:135191
    zf-TRAF; TRAF-type zinc finger
    cd16640
    Location:5091
    RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins
  3. NM_001422425.1NP_001409354.1  TNF receptor-associated factor 3 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC122023, AC127580
    UniProtKB/Swiss-Prot
    B2RPW3, Q60803, Q62380
  4. NM_001422426.1NP_001409355.1  TNF receptor-associated factor 3 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC122023, AC127580
    UniProtKB/Swiss-Prot
    B2RPW3, Q60803, Q62380
  5. NM_011632.3NP_035762.2  TNF receptor-associated factor 3 isoform a

    See identical proteins and their annotated locations for NP_035762.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC122023, AK147362, BC137634, BF661650, CJ127244
    Consensus CDS
    CCDS26175.1
    UniProtKB/Swiss-Prot
    B2RPW3, Q60803, Q62380
    UniProtKB/TrEMBL
    Q3UHM2
    Related
    ENSMUSP00000021706.5, ENSMUST00000021706.11
    Conserved Domains (5) summary
    COG1196
    Location:251432
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd03777
    Location:377562
    MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam02176
    Location:135191
    zf-TRAF; TRAF-type zinc finger
    cd16640
    Location:5091
    RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins
    cl40617
    Location:196246
    zf-TRAF; TRAF-type zinc finger

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    111132799..111233589
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515802.3XP_006515865.1  TNF receptor-associated factor 3 isoform X2

    See identical proteins and their annotated locations for XP_006515865.1

    UniProtKB/TrEMBL
    Q3UHJ1, Q3UHM2
    Conserved Domains (4) summary
    COG1196
    Location:226407
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd03777
    Location:352537
    MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam02176
    Location:135191
    zf-TRAF; TRAF-type zinc finger
    cd16640
    Location:5091
    RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins
  2. XM_036157380.1XP_036013273.1  TNF receptor-associated factor 3 isoform X1

    UniProtKB/Swiss-Prot
    B2RPW3, Q60803, Q62380
    UniProtKB/TrEMBL
    Q3UHM2
    Conserved Domains (5) summary
    COG1196
    Location:251432
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd03777
    Location:377562
    MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam02176
    Location:135191
    zf-TRAF; TRAF-type zinc finger
    cd16640
    Location:5091
    RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins
    cl40617
    Location:196246
    zf-TRAF; TRAF-type zinc finger
  3. XM_006515800.3XP_006515863.1  TNF receptor-associated factor 3 isoform X1

    See identical proteins and their annotated locations for XP_006515863.1

    UniProtKB/Swiss-Prot
    B2RPW3, Q60803, Q62380
    UniProtKB/TrEMBL
    Q3UHM2
    Conserved Domains (5) summary
    COG1196
    Location:251432
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd03777
    Location:377562
    MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam02176
    Location:135191
    zf-TRAF; TRAF-type zinc finger
    cd16640
    Location:5091
    RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins
    cl40617
    Location:196246
    zf-TRAF; TRAF-type zinc finger
  4. XM_006515799.2XP_006515862.1  TNF receptor-associated factor 3 isoform X1

    See identical proteins and their annotated locations for XP_006515862.1

    UniProtKB/Swiss-Prot
    B2RPW3, Q60803, Q62380
    UniProtKB/TrEMBL
    Q3UHM2
    Conserved Domains (5) summary
    COG1196
    Location:251432
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd03777
    Location:377562
    MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam02176
    Location:135191
    zf-TRAF; TRAF-type zinc finger
    cd16640
    Location:5091
    RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins
    cl40617
    Location:196246
    zf-TRAF; TRAF-type zinc finger
  5. XM_030246684.2XP_030102544.1  TNF receptor-associated factor 3 isoform X1

    UniProtKB/Swiss-Prot
    B2RPW3, Q60803, Q62380
    UniProtKB/TrEMBL
    Q3UHM2
    Conserved Domains (5) summary
    COG1196
    Location:251432
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd03777
    Location:377562
    MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam02176
    Location:135191
    zf-TRAF; TRAF-type zinc finger
    cd16640
    Location:5091
    RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins
    cl40617
    Location:196246
    zf-TRAF; TRAF-type zinc finger

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001048206.1: Suppressed sequence

    Description
    NM_001048206.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.