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Tpo thyroid peroxidase [ Mus musculus (house mouse) ]

Gene ID: 22018, updated on 29-May-2018

Summary

Official Symbol
Tpoprovided by MGI
Official Full Name
thyroid peroxidaseprovided by MGI
Primary source
MGI:MGI:98813
See related
Ensembl:ENSMUSG00000020673 Vega:OTTMUSG00000025268
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
This gene encodes a membrane-bound glycoprotein. The encoded enzyme plays a central role in thyroid gland function. The enzyme functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mice with homozygous missense mutations in this gene exhibit hypothyroid dwarfism and hearing impairment. [provided by RefSeq, Sep 2015]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See Tpo in Genome Data Viewer
Location:
12 A2; 12 13.0 cM
Exon count:
18
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (30054661..30132984, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (30739526..30817474, complement)

Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 31939 Neighboring gene peroxidasin Neighboring gene predicted gene 15691 Neighboring gene predicted gene, 40873 Neighboring gene predicted gene, 32084

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
heme binding IEA
Inferred from Electronic Annotation
more info
 
iodide peroxidase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
embryonic hemopoiesis ISO
Inferred from Sequence Orthology
more info
 
hormone biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
hydrogen peroxide catabolic process IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
thyroid hormone generation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell surface ISO
Inferred from Sequence Orthology
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion HDA PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
thyroid peroxidase
NP_033443.1
XP_011242158.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009417.3NP_033443.1  thyroid peroxidase precursor

    See identical proteins and their annotated locations for NP_033443.1

    Status: REVIEWED

    Source sequence(s)
    AC157276, X60703
    Consensus CDS
    CCDS25857.1
    UniProtKB/Swiss-Prot
    P35419
    Related
    ENSMUSP00000021005.8, OTTMUSP00000030629, ENSMUST00000021005.14, OTTMUST00000062199
    Conserved Domains (4) summary
    cd00033
    Location:730783
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd09825
    Location:161722
    thyroid_peroxidase; Thyroid peroxidase (TPO)
    pfam03098
    Location:145687
    An_peroxidase; Animal haem peroxidase
    pfam07645
    Location:784826
    EGF_CA; Calcium-binding EGF domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

    Range
    30054661..30132984 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243856.1XP_011242158.1  thyroid peroxidase isoform X1

    Conserved Domains (4) summary
    cd00033
    Location:730783
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd09825
    Location:161722
    thyroid_peroxidase; Thyroid peroxidase (TPO)
    pfam03098
    Location:145687
    An_peroxidase; Animal haem peroxidase
    pfam07645
    Location:784826
    EGF_CA; Calcium-binding EGF domain

RNA

  1. XR_872405.1 RNA Sequence

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