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SKA1 spindle and kinetochore associated complex subunit 1 [ Homo sapiens (human) ]

Gene ID: 220134, updated on 4-Dec-2022

Summary

Official Symbol
SKA1provided by HGNC
Official Full Name
spindle and kinetochore associated complex subunit 1provided by HGNC
Primary source
HGNC:HGNC:28109
See related
Ensembl:ENSG00000154839 MIM:616673; AllianceGenome:HGNC:28109
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C18orf24
Summary
Enables microtubule binding activity. Involved in several processes, including chromosome segregation; mitotic cell cycle; and regulation of microtubule polymerization or depolymerization. Located in spindle microtubule. Part of outer kinetochore. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bone marrow (RPKM 4.0), testis (RPKM 3.1) and 12 other tissues See more
Orthologs
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Genomic context

See SKA1 in Genome Data Viewer
Location:
18q21.1
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (50375046..50394168)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (50576800..50595915)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (47901416..47920538)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 458 Neighboring gene uncharacterized LOC105372114 Neighboring gene uncharacterized LOC105372115 Neighboring gene CRISPRi-validated cis-regulatory element chr18.1136

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC10200

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell division IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chromosome segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of microtubule polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of microtubule polymerization or depolymerization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in centriolar satellite IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in intercellular bridge IDA
Inferred from Direct Assay
more info
 
located_in kinetochore IPI
Inferred from Physical Interaction
more info
PubMed 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
is_active_in mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of outer kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of outer kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in spindle microtubule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
spindle and kinetochore-associated protein 1
Names
spindle and KT (kinetochore) associated 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039535.3NP_001034624.1  spindle and kinetochore-associated protein 1

    See identical proteins and their annotated locations for NP_001034624.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC105227, BC015606, BC015706, BU659790, BX956145, CN403719
    Consensus CDS
    CCDS11946.1
    UniProtKB/Swiss-Prot
    B4E0P4, Q96BD8
    UniProtKB/TrEMBL
    A0A024R294
    Related
    ENSP00000381470.1, ENST00000398452.6
    Conserved Domains (1) summary
    pfam07160
    Location:17246
    SKA1; Spindle and kinetochore-associated protein 1
  2. NM_145060.4NP_659497.1  spindle and kinetochore-associated protein 1

    See identical proteins and their annotated locations for NP_659497.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC105227, BC015606, BC015706, BU659790, BX956145
    Consensus CDS
    CCDS11946.1
    UniProtKB/Swiss-Prot
    B4E0P4, Q96BD8
    UniProtKB/TrEMBL
    A0A024R294
    Related
    ENSP00000285116.3, ENST00000285116.8
    Conserved Domains (1) summary
    pfam07160
    Location:17246
    SKA1; Spindle and kinetochore-associated protein 1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    50375046..50394168
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NW_003315956.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    82853..101975
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    50576800..50595915
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)