Format

Send to:

Choose Destination

LTO1 LTO1 maturation factor of ABCE1 [ Homo sapiens (human) ]

Gene ID: 220064, updated on 1-Jun-2020

Summary

Official Symbol
LTO1provided by HGNC
Official Full Name
LTO1 maturation factor of ABCE1provided by HGNC
Primary source
HGNC:HGNC:17589
See related
Ensembl:ENSG00000149716 MIM:607224
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CIAB1; TAOS1; ORAOV1
Expression
Ubiquitous expression in testis (RPKM 2.2), skin (RPKM 2.1) and 25 other tissues See more
Orthologs

Genomic context

See LTO1 in Genome Data Viewer
Location:
11q13.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (69665563..69675354, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (69480331..69490165, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs1920 Neighboring gene long intergenic non-protein coding RNA 1488 Neighboring gene cyclin D1 Neighboring gene FGF19 5' regulatory region Neighboring gene fibroblast growth factor 19

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
protein maturation by [4Fe-4S] cluster transfer IDA
Inferred from Direct Assay
more info
PubMed 
ribosomal large subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
telomere maintenance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translational initiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
protein LTO1 homolog
Names
LTO1, ABCE1 maturation factor
oral cancer overexpressed 1
oral cancer overexpressed protein 1-A
oral cancer-overexpressed protein 1
tumor-amplified and overexpressed sequence 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153451.3NP_703152.1  protein LTO1 homolog

    See identical proteins and their annotated locations for NP_703152.1

    Status: VALIDATED

    Source sequence(s)
    AF503940, AK026600
    Consensus CDS
    CCDS8192.1
    UniProtKB/Swiss-Prot
    Q8WV07
    UniProtKB/TrEMBL
    A0A024R5H3
    Related
    ENSP00000279147.4, ENST00000279147.8
    Conserved Domains (1) summary
    pfam09811
    Location:2260
    Yae1_N; Essential protein Yae1, N terminal

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    69665563..69675354 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718470.3XP_006718533.1  protein LTO1 homolog isoform X1

    See identical proteins and their annotated locations for XP_006718533.1

    UniProtKB/Swiss-Prot
    Q8WV07
    UniProtKB/TrEMBL
    A0A024R5H3
    Related
    ENSP00000446129.1, ENST00000535657.5
    Conserved Domains (1) summary
    pfam09811
    Location:2260
    Yae1_N; Essential protein Yae1, N terminal
Support Center