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LTO1 LTO1 maturation factor of ABCE1 [ Homo sapiens (human) ]

Gene ID: 220064, updated on 12-Feb-2024

Summary

Official Symbol
LTO1provided by HGNC
Official Full Name
LTO1 maturation factor of ABCE1provided by HGNC
Primary source
HGNC:HGNC:17589
See related
Ensembl:ENSG00000149716 MIM:607224; AllianceGenome:HGNC:17589
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CIAB1; TAOS1; ORAOV1
Summary
Involved in protein maturation by [4Fe-4S] cluster transfer; ribosomal large subunit biogenesis; and translational initiation. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 2.2), skin (RPKM 2.1) and 25 other tissues See more
Orthologs
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Genomic context

See LTO1 in Genome Data Viewer
Location:
11q13.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (69665563..69675353, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (69682440..69692229, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (69480331..69490121, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:69456195-69456897 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3694 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3695 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3696 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69458416-69459160 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69462137-69462880 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69463625-69464368 Neighboring gene cyclin D1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69469698-69470635 Neighboring gene uncharacterized LOC124902704 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69472515-69473242 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69475622-69476122 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69476123-69476623 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3697 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:69489913-69490413 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:69500700-69500870 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:69503328-69504527 Neighboring gene Sharpr-MPRA regulatory region 8818 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69515109-69516061 Neighboring gene FGF19 5' regulatory region Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69521101-69521730 Neighboring gene fibroblast growth factor 19 Neighboring gene MPRA-validated peak1327 silencer Neighboring gene FGF19 upstream enhancer Neighboring gene DNAJB6 pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in protein maturation by [4Fe-4S] cluster transfer IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ribosomal large subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in telomere maintenance IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in translational initiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
protein LTO1 homolog
Names
LTO1, ABCE1 maturation factor
oral cancer overexpressed 1
oral cancer overexpressed protein 1-A
oral cancer-overexpressed protein 1
tumor-amplified and overexpressed sequence 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153451.3NP_703152.1  protein LTO1 homolog

    See identical proteins and their annotated locations for NP_703152.1

    Status: VALIDATED

    Source sequence(s)
    AF503940, AK026600
    Consensus CDS
    CCDS8192.1
    UniProtKB/Swiss-Prot
    B2R4R2, Q8NFK0, Q8WV07
    UniProtKB/TrEMBL
    F5GZY6
    Related
    ENSP00000279147.5, ENST00000279147.9
    Conserved Domains (1) summary
    pfam09811
    Location:2260
    Yae1_N; Essential protein Yae1, N terminal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    69665563..69675353 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718470.4XP_006718533.1  protein LTO1 homolog isoform X1

    See identical proteins and their annotated locations for XP_006718533.1

    UniProtKB/Swiss-Prot
    B2R4R2, Q8NFK0, Q8WV07
    UniProtKB/TrEMBL
    F5GZY6
    Related
    ENSP00000446129.1, ENST00000535657.5
    Conserved Domains (1) summary
    pfam09811
    Location:2260
    Yae1_N; Essential protein Yae1, N terminal

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    69682440..69692229 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368034.1XP_054224009.1  protein LTO1 homolog isoform X1

    UniProtKB/Swiss-Prot
    B2R4R2, Q8NFK0, Q8WV07
    UniProtKB/TrEMBL
    F5GZY6