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GDPD4 glycerophosphodiester phosphodiesterase domain containing 4 [ Homo sapiens (human) ]

Gene ID: 220032, updated on 22-Sep-2022

Summary

Official Symbol
GDPD4provided by HGNC
Official Full Name
glycerophosphodiester phosphodiesterase domain containing 4provided by HGNC
Primary source
HGNC:HGNC:24849
See related
Ensembl:ENSG00000178795 AllianceGenome:HGNC:24849
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GDE6
Summary
Predicted to enable metal ion binding activity and phosphoric diester hydrolase activity. Predicted to be involved in lipid metabolic process. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See GDPD4 in Genome Data Viewer
Location:
11q13.5
Exon count:
19
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (77216558..77301699, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (77149168..77234300, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (76927603..77012731, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene calpain 5 Neighboring gene olfactory marker protein Neighboring gene myosin VIIA Neighboring gene TOMM20 pseudogene 1 Neighboring gene p21 (RAC1) activated kinase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables glycerophosphodiester phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
glycerophosphodiester phosphodiesterase domain-containing protein 4
Names
GDPD domain containing protein
glycerophosphodiester phosphodiesterase 6
ugpQ

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_182833.3NP_878253.1  glycerophosphodiester phosphodiesterase domain-containing protein 4

    See identical proteins and their annotated locations for NP_878253.1

    Status: VALIDATED

    Source sequence(s)
    AP001855, AP002827
    Consensus CDS
    CCDS8249.1
    UniProtKB/Swiss-Prot
    Q6W3E5
    Related
    ENSP00000320815.4, ENST00000315938.5
    Conserved Domains (2) summary
    cd08610
    Location:179491
    GDPD_GDE6; Glycerophosphodiester phosphodiesterase domain of mammalian glycerophosphodiester phosphodiesterase GDE6 and similar proteins
    COG0584
    Location:197456
    UgpQ; Glycerophosphoryl diester phosphodiesterase [Lipid transport and metabolism]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    77216558..77301699 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544834.1XP_011543136.1  glycerophosphodiester phosphodiesterase domain-containing protein 4 isoform X3

    Related
    ENSP00000365390.2, ENST00000376217.6
    Conserved Domains (2) summary
    COG0584
    Location:223482
    UgpQ; Glycerophosphoryl diester phosphodiesterase [Lipid transport and metabolism]
    cl14615
    Location:205517
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
  2. XM_047426557.1XP_047282513.1  glycerophosphodiester phosphodiesterase domain-containing protein 4 isoform X1

  3. XM_047426558.1XP_047282514.1  glycerophosphodiester phosphodiesterase domain-containing protein 4 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    77149168..77234300 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)