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CYB561A3 cytochrome b561 family member A3 [ Homo sapiens (human) ]

Gene ID: 220002, updated on 17-Jun-2019

Summary

Official Symbol
CYB561A3provided by HGNC
Official Full Name
cytochrome b561 family member A3provided by HGNC
Primary source
HGNC:HGNC:23014
See related
Ensembl:ENSG00000162144
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LCYTB; CYBASC3
Expression
Broad expression in adrenal (RPKM 44.3), lymph node (RPKM 18.0) and 23 other tissues See more
Orthologs

Genomic context

See CYB561A3 in Genome Data Viewer
Location:
11q12.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (61348745..61362283, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (61116220..61129755, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene von Willebrand factor C and EGF domains Neighboring gene damage specific DNA binding protein 1 Neighboring gene triokinase and FMN cyclase Neighboring gene transmembrane protein 138 Neighboring gene transmembrane protein 216

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ39724, MGC20446

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
late endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
lysosomal membrane HDA PubMed 
lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lysosomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
cytochrome b ascorbate-dependent protein 3
Names
cytochrome b, ascorbate dependent 3
lysosomal cytochrome b

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161452.2NP_001154924.1  cytochrome b ascorbate-dependent protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001154924.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate splice junction at the 5' end of the last exon compared to variant 4. The encoded isoform (2) has a shorter and distinct C-terminus compared to isoform 3. Variants 2 and 3 both encode the same isoform (2).
    Source sequence(s)
    AK025870, AK225754, AP003108, BM692535, BP296553, BP396674, CF541093, DA948287
    Consensus CDS
    CCDS8004.1
    UniProtKB/Swiss-Prot
    Q8NBI2
    Related
    ENSP00000437390.1, ENST00000536915.5
    Conserved Domains (1) summary
    cd08762
    Location:19188
    Cyt_b561_CYBASC3; Vertebrate cytochrome b(561), CYBASC3 gene product
  2. NM_001161454.1NP_001154926.1  cytochrome b ascorbate-dependent protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001154926.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) contains an alternate exon and uses an alternate splice junction at the 5' end of the last exon compared to variant 4. The resulting isoform (1) is longer at the N-terminus and has a shorter and distinct C-terminus compared to isoform 3.
    Source sequence(s)
    AA085565, AK025870, AK297084, BP366144, BP396674, CF125719, DC378209, DC389589
    Consensus CDS
    CCDS53639.1
    UniProtKB/Swiss-Prot
    Q8NBI2
    Related
    ENSP00000398979.2, ENST00000426130.6
    Conserved Domains (1) summary
    cd08762
    Location:36205
    Cyt_b561_CYBASC3; Vertebrate cytochrome b(561), CYBASC3 gene product
  3. NM_001300763.2NP_001287692.1  cytochrome b ascorbate-dependent protein 3 isoform 3

    See identical proteins and their annotated locations for NP_001287692.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (3).
    Source sequence(s)
    AI813810, AK056751, AP003108, CF125719
    Consensus CDS
    CCDS73296.1
    UniProtKB/Swiss-Prot
    Q8NBI2
    UniProtKB/TrEMBL
    F5H1Q2
    Related
    ENSP00000389745.2, ENST00000447532.6
    Conserved Domains (1) summary
    cd08762
    Location:19188
    Cyt_b561_CYBASC3; Vertebrate cytochrome b(561), CYBASC3 gene product
  4. NM_153611.5NP_705839.3  cytochrome b ascorbate-dependent protein 3 isoform 2

    See identical proteins and their annotated locations for NP_705839.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction at the 5' end of the last exon compared to variant 4. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 3. Variants 2 and 3 both encode the same isoform (2).
    Source sequence(s)
    AK056751, AK075559, AP003108, BP396674
    Consensus CDS
    CCDS8004.1
    UniProtKB/Swiss-Prot
    Q8NBI2
    Related
    ENSP00000294072.3, ENST00000294072.8
    Conserved Domains (1) summary
    cd08762
    Location:19188
    Cyt_b561_CYBASC3; Vertebrate cytochrome b(561), CYBASC3 gene product

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    61348745..61362283 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544821.2XP_011543123.1  cytochrome b ascorbate-dependent protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011543123.1

    Conserved Domains (1) summary
    cd08762
    Location:36205
    Cyt_b561_CYBASC3; Vertebrate cytochrome b(561), CYBASC3 gene product
  2. XM_011544823.2XP_011543125.1  cytochrome b ascorbate-dependent protein 3 isoform X2

    See identical proteins and their annotated locations for XP_011543125.1

    UniProtKB/TrEMBL
    F5H1Q2
    Conserved Domains (1) summary
    cd08762
    Location:19188
    Cyt_b561_CYBASC3; Vertebrate cytochrome b(561), CYBASC3 gene product
  3. XM_024448399.1XP_024304167.1  cytochrome b ascorbate-dependent protein 3 isoform X4

    Conserved Domains (1) summary
    cl23723
    Location:36148
    Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...
  4. XM_024448398.1XP_024304166.1  cytochrome b ascorbate-dependent protein 3 isoform X3

    Conserved Domains (1) summary
    cl23723
    Location:36148
    Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...
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