U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MPEG1 macrophage expressed 1 [ Homo sapiens (human) ]

Gene ID: 219972, updated on 17-Sep-2024

Summary

Official Symbol
MPEG1provided by HGNC
Official Full Name
macrophage expressed 1provided by HGNC
Primary source
HGNC:HGNC:29619
See related
Ensembl:ENSG00000197629 MIM:610390; AllianceGenome:HGNC:29619
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P-2; MPG1; MPS1; IMD77; Mpg-1
Summary
Involved in defense response to Gram-negative bacterium and defense response to Gram-positive bacterium. Located in cytoplasmic vesicle. Implicated in primary immunodeficiency disease. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See MPEG1 in Genome Data Viewer
Location:
11q12.1
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (59208510..59212927, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (59157683..59162100, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (58975983..58980400, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene basic proline-rich protein-like Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:58938742-58939282 Neighboring gene Sharpr-MPRA regulatory region 11967 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3361 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:58940291-58941119 Neighboring gene uncharacterized LOC124902675 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3362 Neighboring gene deltex E3 ubiquitin ligase 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3363 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:58967822-58969021 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4752 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4753 Neighboring gene RNA, 7SL, cytoplasmic 42, pseudogene Neighboring gene tryptophanyl-tRNA synthetase 1 pseudogene 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat downregulates the expression of macrophage expressed 1 (MPEG1) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC132657, MGC138435

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables wide pore channel activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in antibacterial innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in antigen processing and presentation of exogenous peptide antigen ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class I ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to Gram-negative bacterium ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in defense response to Gram-positive bacterium IDA
Inferred from Direct Assay
more info
PubMed 
involved_in defense response to Gram-positive bacterium ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in defense response to bacterium IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dendritic cell antigen processing and presentation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in phagocytic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in phagocytic vesicle membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
is_active_in phagolysosome membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
macrophage-expressed gene 1 protein
Names
macrophage expressed gene 1
macrophage gene 1 protein
perforin 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039396.2NP_001034485.1  macrophage-expressed gene 1 protein precursor

    See identical proteins and their annotated locations for NP_001034485.1

    Status: VALIDATED

    Source sequence(s)
    AP002358, AW205154, BC104997, DA946058
    Consensus CDS
    CCDS41650.1
    UniProtKB/Swiss-Prot
    Q2M1T6, Q2M385, Q8TEF8
    UniProtKB/TrEMBL
    B3KUT2
    Related
    ENSP00000354335.3, ENST00000361050.4
    Conserved Domains (1) summary
    pfam01823
    Location:125341
    MACPF; MAC/Perforin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    59208510..59212927 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    59157683..59162100 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)