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MPEG1 macrophage expressed 1 [ Homo sapiens (human) ]

Gene ID: 219972, updated on 26-Nov-2021

Summary

Official Symbol
MPEG1provided by HGNC
Official Full Name
macrophage expressed 1provided by HGNC
Primary source
HGNC:HGNC:29619
See related
Ensembl:ENSG00000197629 MIM:610390
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P-2; MPG1; MPS1; IMD77; Mpg-1
Orthologs
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Genomic context

See MPEG1 in Genome Data Viewer
Location:
11q12.1
Exon count:
1
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (59208510..59212927, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (58975983..58980400, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene FAM111 trypsin like peptidase A Neighboring gene Sharpr-MPRA regulatory region 11967 Neighboring gene deltex E3 ubiquitin ligase 4 Neighboring gene RNA, 7SL, cytoplasmic 42, pseudogene Neighboring gene tryptophanyl-tRNA synthetase 1 pseudogene 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat downregulates the expression of macrophage expressed 1 (MPEG1) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC132657, MGC138435

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to Gram-negative bacterium ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in defense response to Gram-positive bacterium IDA
Inferred from Direct Assay
more info
PubMed 
involved_in defense response to Gram-positive bacterium ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in defense response to bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in pore formation in membrane of other organism ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in phagocytic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
macrophage-expressed gene 1 protein
Names
macrophage expressed gene 1
macrophage gene 1 protein
perforin 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039396.2NP_001034485.1  macrophage-expressed gene 1 protein precursor

    See identical proteins and their annotated locations for NP_001034485.1

    Status: VALIDATED

    Source sequence(s)
    AP002358, AW205154, BC104997, DA946058
    Consensus CDS
    CCDS41650.1
    UniProtKB/Swiss-Prot
    Q2M385
    Related
    ENSP00000354335.3, ENST00000361050.4
    Conserved Domains (1) summary
    pfam01823
    Location:125341
    MACPF; MAC/Perforin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    59208510..59212927 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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