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OR1S2 olfactory receptor family 1 subfamily S member 2 [ Homo sapiens (human) ]

Gene ID: 219958, updated on 31-Oct-2022

Summary

Official Symbol
OR1S2provided by HGNC
Official Full Name
olfactory receptor family 1 subfamily S member 2provided by HGNC
Primary source
HGNC:HGNC:15141
See related
Ensembl:ENSG00000197887 AllianceGenome:HGNC:15141
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR11-231
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See OR1S2 in Genome Data Viewer
Location:
11q12.1
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (58203204..58204142, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (58152627..58153565, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (57970676..57971614, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 9 subfamily Q member 1 Neighboring gene olfactory receptor family 5 subfamily BL member 1 pseudogene Neighboring gene olfactory receptor family 9 subfamily Q member 2 Neighboring gene olfactory receptor family 1 subfamily S member 1 Neighboring gene olfactory receptor family 10 subfamily Q member 1

Genomic regions, transcripts, and products

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in detection of chemical stimulus involved in sensory perception of smell IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
olfactory receptor 1S2
Names
olfactory receptor OR11-231

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053130.1 RefSeqGene

    Range
    5040..5978
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001004459.2NP_001004459.2  olfactory receptor 1S2

    Status: VALIDATED

    Source sequence(s)
    AP004247
    Consensus CDS
    CCDS31545.2
    UniProtKB/TrEMBL
    A0A286YFI5
    Related
    ENSP00000493223.1, ENST00000641683.2
    Conserved Domains (1) summary
    cd15918
    Location:25294
    7tmA_OR1_7-like; olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    58203204..58204142 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    58152627..58153565 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)