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MRPL21 mitochondrial ribosomal protein L21 [ Homo sapiens (human) ]

Gene ID: 219927, updated on 1-Jun-2020

Summary

Official Symbol
MRPL21provided by HGNC
Official Full Name
mitochondrial ribosomal protein L21provided by HGNC
Primary source
HGNC:HGNC:14479
See related
Ensembl:ENSG00000197345 MIM:611834
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L21mt; MRP-L21
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding different isoforms were identified through sequence analysis although some may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in heart (RPKM 16.0), thyroid (RPKM 12.1) and 25 other tissues See more
Orthologs

Genomic context

See MRPL21 in Genome Data Viewer
Location:
11q13.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (68891276..68903832, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (68658744..68671303, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene carnitine palmitoyltransferase 1A Neighboring gene long intergenic non-protein coding RNA 2701 Neighboring gene immunoglobulin mu DNA binding protein 2 Neighboring gene MAS related GPR family member D

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC62013

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
mitochondrial translational elongation TAS
Traceable Author Statement
more info
 
mitochondrial translational termination TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial large ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
39S ribosomal protein L21, mitochondrial
Names
mitochondrial large ribosomal subunit protein bL21m

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181514.2NP_852615.1  39S ribosomal protein L21, mitochondrial isoform d

    See identical proteins and their annotated locations for NP_852615.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) encodes the longest protein (isoform d).
    Source sequence(s)
    AK096756, BM916618
    Consensus CDS
    CCDS8186.1
    UniProtKB/Swiss-Prot
    Q7Z2W9
    Related
    ENSP00000354580.2, ENST00000362034.7
    Conserved Domains (1) summary
    pfam00829
    Location:96198
    Ribosomal_L21p; Ribosomal prokaryotic L21 protein
  2. NM_181515.2NP_852616.1  39S ribosomal protein L21, mitochondrial isoform a

    See identical proteins and their annotated locations for NP_852616.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) uses a different splice site in the 5' end, compared to variant 4, that likely leads to the use of a downstream start codon. The predicted protein (isoform a) is shorter than isoform d. The predicted ORF of this transcript has not been experimentally confirmed.
    Source sequence(s)
    AK096756, BM916618
    Consensus CDS
    CCDS44662.1
    UniProtKB/Swiss-Prot
    Q7Z2W9
    UniProtKB/TrEMBL
    A0A024R5G7
    Related
    ENSP00000389400.2, ENST00000450904.6
    Conserved Domains (1) summary
    pfam00829
    Location:1794
    Ribosomal_L21p; Ribosomal prokaryotic L21 protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    68891276..68903832 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005273823.4XP_005273880.1  39S ribosomal protein L21, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_005273880.1

    UniProtKB/TrEMBL
    B4DXI4
    Conserved Domains (1) summary
    pfam00829
    Location:102179
    Ribosomal_L21p; Ribosomal prokaryotic L21 protein

RNA

  1. XR_247190.4 RNA Sequence

    Related
    ENST00000541279.1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_181512.1: Suppressed sequence

    Description
    NM_181512.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
  2. NM_181513.1: Suppressed sequence

    Description
    NM_181513.1: This RefSeq was permanently suppressed because its splicing pattern is predominantly found in cancerous tissues and contains non-consensus splice junctions.
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