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TLCD5 TLC domain containing 5 [ Homo sapiens (human) ]

Gene ID: 219902, updated on 23-Nov-2021

Summary

Official Symbol
TLCD5provided by HGNC
Official Full Name
TLC domain containing 5provided by HGNC
Primary source
HGNC:HGNC:28280
See related
Ensembl:ENSG00000181264
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TMEM136
Expression
Broad expression in adrenal (RPKM 4.7), brain (RPKM 4.1) and 21 other tissues See more
Orthologs
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Genomic context

See TLCD5 in Genome Data Viewer
Location:
11q23.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (120325299..120333686)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (120196008..120204395)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 564 Neighboring gene uncharacterized LOC105369531 Neighboring gene uncharacterized LOC649133 Neighboring gene POU class 2 homeobox 3 Neighboring gene Rho guanine nucleotide exchange factor 12 Neighboring gene uncharacterized LOC107984400 Neighboring gene glutamate ionotropic receptor kainate type subunit 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC17839

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
TLC domain-containing protein 5
Names
transmembrane protein 136

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198670.2NP_001185599.1  TLC domain-containing protein 5 isoform a

    See identical proteins and their annotated locations for NP_001185599.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AK128040, AP001150, BC015232
    Consensus CDS
    CCDS55792.1
    UniProtKB/Swiss-Prot
    Q6ZRR5
    Related
    ENSP00000312672.2, ENST00000314475.6
    Conserved Domains (1) summary
    smart00724
    Location:51244
    TLC; TRAM, LAG1 and CLN8 homology domains
  2. NM_001198671.2NP_001185600.1  TLC domain-containing protein 5 isoform c

    See identical proteins and their annotated locations for NP_001185600.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AP001150, DA097438
    Consensus CDS
    CCDS55793.1
    UniProtKB/Swiss-Prot
    Q6ZRR5
    Related
    ENSP00000364236.3, ENST00000375095.3
    Conserved Domains (1) summary
    smart00724
    Location:29222
    TLC; TRAM, LAG1 and CLN8 homology domains
  3. NM_001198672.2NP_001185601.1  TLC domain-containing protein 5 isoform d precursor

    See identical proteins and their annotated locations for NP_001185601.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4, 5, and 7 all encode the same isoform (d).
    Source sequence(s)
    AK128040, AK289680, AP001150
    UniProtKB/Swiss-Prot
    Q6ZRR5
    UniProtKB/TrEMBL
    A8K0W5
    Conserved Domains (1) summary
    cl02759
    Location:1121
    TRAM_LAG1_CLN8; TLC domain
  4. NM_001198673.2NP_001185602.1  TLC domain-containing protein 5 isoform d precursor

    See identical proteins and their annotated locations for NP_001185602.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4, 5, and 7 all encode the same isoform (d).
    Source sequence(s)
    AP001150, DA331965
    UniProtKB/Swiss-Prot
    Q6ZRR5
    UniProtKB/TrEMBL
    A8K0W5
    Conserved Domains (1) summary
    cl02759
    Location:1121
    TRAM_LAG1_CLN8; TLC domain
  5. NM_001198674.2NP_001185603.1  TLC domain-containing protein 5 isoform e

    See identical proteins and their annotated locations for NP_001185603.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate splice junction at the 5' end of an exon and lacks an alternate in-frame segment compared to variant 1. The resulting isoform (e) is shorter at the N-terminus and lacks an internal segment compared to isoform a.
    Source sequence(s)
    AK128040, AK294713, AP001150
    UniProtKB/Swiss-Prot
    Q6ZRR5
    Conserved Domains (1) summary
    cl02759
    Location:2995
    TRAM_LAG1_CLN8; TLC domain
  6. NM_001198675.2NP_001185604.1  TLC domain-containing protein 5 isoform d precursor

    See identical proteins and their annotated locations for NP_001185604.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks an alternate exon compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4, 5, and 7 all encode the same isoform (d).
    Source sequence(s)
    AK128040, AP001150
    UniProtKB/Swiss-Prot
    Q6ZRR5
    UniProtKB/TrEMBL
    A8K0W5
    Related
    ENST00000531346.1
    Conserved Domains (1) summary
    cl02759
    Location:1121
    TRAM_LAG1_CLN8; TLC domain
  7. NM_174926.3NP_777586.1  TLC domain-containing protein 5 isoform b

    See identical proteins and their annotated locations for NP_777586.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AK128040, AP001150, BC015232
    Consensus CDS
    CCDS8432.1
    UniProtKB/Swiss-Prot
    Q6ZRR5
    Related
    ENSP00000434862.1, ENST00000529187.1
    Conserved Domains (1) summary
    cl02759
    Location:51117
    TRAM_LAG1_CLN8; TLC domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    120325299..120333686
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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