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Tpd52l1 tumor protein D52-like 1 [ Mus musculus (house mouse) ]

Gene ID: 21987, updated on 26-Sep-2022

Summary

Official Symbol
Tpd52l1provided by MGI
Official Full Name
tumor protein D52-like 1provided by MGI
Primary source
MGI:MGI:1298386
See related
Ensembl:ENSMUSG00000000296 AllianceGenome:MGI:1298386
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D53
Summary
Predicted to enable protein homodimerization activity. Predicted to be involved in G2/M transition of mitotic cell cycle and positive regulation of signal transduction. Predicted to be located in early endosome and perinuclear region of cytoplasm. Predicted to be active in cytoplasm. Is expressed in brain; limb bud; otic capsule; and temporal bone petrous part. Orthologous to human TPD52L1 (TPD52 like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in genital fat pad adult (RPKM 17.3), ovary adult (RPKM 8.3) and 19 other tissues See more
Orthologs
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Genomic context

See Tpd52l1 in Genome Data Viewer
Location:
10; 10 A4
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (31208369..31321989, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (31332373..31445987, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 pseudogene Neighboring gene HD domain containing 2 Neighboring gene SPT4B, DSIF elongation factor subunit Neighboring gene predicted gene, 51764 Neighboring gene ring finger protein 217 Neighboring gene high mobility group box 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359364.1NP_001346293.1  tumor protein D53 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AI843750, AV016496, BC141068, CX238524
    Consensus CDS
    CCDS87983.1
    UniProtKB/TrEMBL
    B2RUC1
    Related
    ENSMUSP00000149177.2, ENSMUST00000213528.2
    Conserved Domains (1) summary
    pfam04201
    Location:12192
    TPD52; tumor protein D52 family
  2. NM_001359365.1NP_001346294.1  tumor protein D53 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AI843750, AV016496, BC145322, CX238524
    Conserved Domains (1) summary
    pfam04201
    Location:12133
    TPD52; tumor protein D52 family
  3. NM_001359366.1NP_001346295.1  tumor protein D53 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AI843750, AK131855, AV016496, CX238524
    Consensus CDS
    CCDS87980.1
    UniProtKB/TrEMBL
    Q3V2G6
    Related
    ENSMUSP00000149749.2, ENSMUST00000214644.2
    Conserved Domains (1) summary
    pfam04201
    Location:12129
    TPD52; tumor protein D52 family
  4. NM_009413.2NP_033439.1  tumor protein D53 isoform 2

    See identical proteins and their annotated locations for NP_033439.1

    Status: VALIDATED

    Source sequence(s)
    AF004428, AV016496, CX238524
    Consensus CDS
    CCDS35877.1
    UniProtKB/Swiss-Prot
    O54818
    Related
    ENSMUSP00000000305.6, ENSMUST00000000305.7
    Conserved Domains (1) summary
    pfam04201
    Location:12187
    TPD52; Tumour protein D52 family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    31208369..31321989 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245062.2XP_030100922.1  tumor protein D53 isoform X1

    UniProtKB/TrEMBL
    A0A1L1ST53
    Related
    ENSMUSP00000150184.2, ENSMUST00000213639.2
    Conserved Domains (1) summary
    pfam04201
    Location:12174
    TPD52; tumor protein D52 family
  2. XM_030245063.2XP_030100923.1  tumor protein D53 isoform X2

    UniProtKB/TrEMBL
    A0A1L1SR11
    Related
    ENSMUSP00000149266.2, ENSMUST00000215515.2
    Conserved Domains (1) summary
    pfam04201
    Location:12131
    TPD52; tumor protein D52 family
  3. XM_030245064.2XP_030100924.1  tumor protein D53 isoform X3

    Conserved Domains (1) summary
    pfam04201
    Location:12133
    TPD52; tumor protein D52 family