SLC37A2 solute carrier family 37 member 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SLC37A2provided by HGNC
Official Full Name: solute carrier family 37 member 2provided by HGNC
Primary source: HGNC:HGNC:20644
See related: Ensembl:ENSG00000134955 MIM:619136; AllianceGenome:HGNC:20644
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SPX2; pp11662
Summary: Enables glucose 6-phosphate:inorganic phosphate antiporter activity. Involved in glucose-6-phosphate transport and phosphate ion transmembrane transport. Is integral component of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in adrenal (RPKM 13.0), salivary gland (RPKM 12.4) and 18 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q24.2

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
110	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (125063305..125090516)
110	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (125091969..125119183)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (124933201..124960412)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Using both living fish embryos and mammalian macrophages, we show that processing depends on the shrinkage and packaging of phagosomes into a unique cellular compartment, the gastrosome, with distinct molecular and ultra-structural characteristics. Loss of the transporter Slc37a2 blocks phagosomal shrinkage, resulting in the expansion of the gastrosome and the dramatic bloating of the cell.
Title: Clearance by Microglia Depends on Packaging of Phagosomes into a Unique Cellular Compartment.
Data show that SLC37A1 and SLC37A2 are endoplasmic reticulum associated, P(i)-linked antiporters, that can transport glucose-6-phosphate.
Title: SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate antiporters.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

D11S2921 (e-PCR)
- UniSTS:152074

D11S2413 (e-PCR)
- UniSTS:1053

D8S2279 (e-PCR)
- UniSTS:473907

D1S1425 (e-PCR)
- UniSTS:149621

SHGC-149448 (e-PCR)
- UniSTS:177013

D11S2773 (e-PCR)
- UniSTS:151974

Homology

Homologs of the SLC37A2 gene: The SLC37A2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, fruit fly, mosquito, A.thaliana, rice, and frog.
Orthologs from Annotation Pipeline: 446 organisms have orthologs with human gene SLC37A2
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables glucose 6-phosphate:inorganic phosphate antiporter activity	EXP Inferred from Experiment more info	PubMed
enables glucose 6-phosphate:inorganic phosphate antiporter activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables glucose 6-phosphate:inorganic phosphate antiporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in carbohydrate transport	IEA Inferred from Electronic Annotation more info
involved_in glucose-6-phosphate transport	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in glucose-6-phosphate transport	IDA Inferred from Direct Assay more info	PubMed
involved_in glucose-6-phosphate transport	TAS Traceable Author Statement more info
involved_in phosphate ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in phosphate ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed

General protein information

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Preferred Names: glucose-6-phosphate exchanger SLC37A2

Names: solute carrier family 37 (glucose-6-phosphate transporter), member 2; solute carrier family 37 (glycerol-3-phosphate transporter), member 2; sugar phosphate exchanger 2; sugar-phosphate exchange protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001145290.2 → NP_001138762.1 glucose-6-phosphate exchanger SLC37A2 isoform 2

See identical proteins and their annotated locations for NP_001138762.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon in the coding region that causes a frameshift. The resulting isoform (2) has a distinct C-terminus compared to isoform 1.

Source sequence(s)

AK290314, AP001007

Consensus CDS

CCDS44757.1

UniProtKB/Swiss-Prot

Q8TED4, Q8TEM2

Related

ENSP00000384407.3, ENST00000403796.7

Conserved Domains (2) summary

cd06174
Location:86 → 481

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

TIGR00881
Location:87 → 463

2A0104; phosphoglycerate transporter family protein
NM_198277.3 → NP_938018.1 glucose-6-phosphate exchanger SLC37A2 isoform 1

See identical proteins and their annotated locations for NP_938018.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK074207, AP001007, BC051314

Consensus CDS

CCDS31714.1

UniProtKB/Swiss-Prot

Q8TED4

Related

ENSP00000311833.4, ENST00000308074.4

Conserved Domains (1) summary

cl27298
Location:25 → 478

UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]