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SLC37A2 solute carrier family 37 member 2 [ Homo sapiens (human) ]

Gene ID: 219855, updated on 5-Jul-2025
Official Symbol
SLC37A2provided by HGNC
Official Full Name
solute carrier family 37 member 2provided by HGNC
Primary source
HGNC:HGNC:20644
See related
Ensembl:ENSG00000134955 MIM:619136; AllianceGenome:HGNC:20644
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPX2; pp11662
Summary
Enables glucose 6-phosphate:phosphate antiporter activity. Involved in glucose-6-phosphate transport and phosphate ion transmembrane transport. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Broad expression in adrenal (RPKM 13.0), salivary gland (RPKM 12.4) and 18 other tissues See more
Orthologs
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See SLC37A2 in Genome Data Viewer
Location:
11q24.2
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (125063305..125090516)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (125091969..125119183)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (124933201..124960412)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:124823758-124824301 Neighboring gene CCDC15 divergent transcript Neighboring gene coiled-coil domain containing 15 Neighboring gene MPRA-validated peak1499 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:124853252-124854004 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4036 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4037 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5692 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5693 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:124951446-124951995 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:124952423-124953622 Neighboring gene transmembrane protein 218 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5694 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:124981662-124982574 Neighboring gene keratin 18 pseudogene 59

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. The human sugar-phosphate/phosphate exchanger family SLC37. Bartoloni L, et al. Pflugers Arch, 2004 Feb. PMID 12811562
  2. Clearance by Microglia Depends on Packaging of Phagosomes into a Unique Cellular Compartment. Villani A, et al. Dev Cell, 2019 Apr 8. PMID 30880002
  3. SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate antiporters. Pan CJ, et al. PLoS One, 2011. PMID 21949678, Free PMC Article
  4. Cryo-EM structure of the KLHL22 E3 ligase bound to an oligomeric metabolic enzyme. Teng F, et al. Structure, 2023 Nov 2. PMID 37788672
  5. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ00171, MGC71430

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables glucose 6-phosphate:phosphate antiporter activity EXP
Inferred from Experiment
more info
 PubMed 
enables glucose 6-phosphate:phosphate antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucose 6-phosphate:phosphate antiporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glucose 6-phosphate:phosphate antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glucose-6-phosphate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glucose-6-phosphate transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glucose-6-phosphate transport TAS
Traceable Author Statement
more info
  
involved_in phosphate ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphate ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphate ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in organelle membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
glucose-6-phosphate exchanger SLC37A2
Names
solute carrier family 37 (glucose-6-phosphate transporter), member 2
solute carrier family 37 (glycerol-3-phosphate transporter), member 2
sugar phosphate exchanger 2
sugar-phosphate exchange protein 2

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145290.2 → NP_001138762.1  glucose-6-phosphate exchanger SLC37A2 isoform 2

    See identical proteins and their annotated locations for NP_001138762.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region that causes a frameshift. The resulting isoform (2) has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK290314, AP001007
    Consensus CDS
    CCDS44757.1
    UniProtKB/Swiss-Prot
    A8K2P9, Q6P599, Q7Z7P8, Q8TED4, Q8TEM2
    Related
    ENSP00000384407.3, ENST00000403796.7
    Conserved Domains (2) summary
    cd06174
    Location:86 → 481
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00881
    Location:87 → 463
    2A0104; phosphoglycerate transporter family protein

  2. NM_198277.3 → NP_938018.1  glucose-6-phosphate exchanger SLC37A2 isoform 1

    See identical proteins and their annotated locations for NP_938018.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK074207, AP001007, BC051314
    Consensus CDS
    CCDS31714.1
    UniProtKB/Swiss-Prot
    Q8TED4
    Related
    ENSP00000311833.4, ENST00000308074.4
    Conserved Domains (1) summary
    cl27298
    Location:25 → 478
    UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    125063305..125090516
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047426544.1 → XP_047282500.1  glucose-6-phosphate exchanger SLC37A2 isoform X1

RNA

  1. XR_007062459.1 RNA Sequence

  2. XR_007062460.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    125091969..125119183
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054367989.1 → XP_054223964.1  glucose-6-phosphate exchanger SLC37A2 isoform X1

RNA

  1. XR_008488359.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TED4.2 GenPept UniProtKB/Swiss-Prot:Q8TED4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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