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TMEM218 transmembrane protein 218 [ Homo sapiens (human) ]

Gene ID: 219854, updated on 5-Sep-2021

Summary

Official Symbol
TMEM218provided by HGNC
Official Full Name
transmembrane protein 218provided by HGNC
Primary source
HGNC:HGNC:27344
See related
Ensembl:ENSG00000150433 MIM:619285
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in fat (RPKM 5.9), adrenal (RPKM 3.3) and 25 other tissues See more
Orthologs
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Genomic context

See TMEM218 in Genome Data Viewer
Location:
11q24.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (125094389..125111759, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (124964285..124981522, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 15 Neighboring gene solute carrier family 37 member 2 Neighboring gene keratin 18 pseudogene 59 Neighboring gene PKNOX2 divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp667A247

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cilium IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080546.3NP_001074015.1  transmembrane protein 218 isoform 2

    See identical proteins and their annotated locations for NP_001074015.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
    Source sequence(s)
    AA459752, AA781367, AP001007, BC132716, BC144277, BX094574, CX870447, DB194956
    Consensus CDS
    CCDS31715.1
    UniProtKB/Swiss-Prot
    A2RU14
    Related
    ENSP00000279968.4, ENST00000279968.8
  2. NM_001258238.2NP_001245167.1  transmembrane protein 218 isoform 2

    See identical proteins and their annotated locations for NP_001245167.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
    Source sequence(s)
    AA781367, AP001007, BC132716, BI829527, BX094574, CX870447
    Consensus CDS
    CCDS31715.1
    UniProtKB/Swiss-Prot
    A2RU14
  3. NM_001258239.3NP_001245168.2  transmembrane protein 218 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
    Source sequence(s)
    AP001007
  4. NM_001258240.2NP_001245169.1  transmembrane protein 218 isoform 2

    See identical proteins and their annotated locations for NP_001245169.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
    Source sequence(s)
    AA781367, AP001007, BC132716, BM042315, BM928068, BX094574, CX870447, DA774499
    Consensus CDS
    CCDS31715.1
    UniProtKB/Swiss-Prot
    A2RU14
    Related
    ENSP00000436177.1, ENST00000526175.5
  5. NM_001258241.2NP_001245170.1  transmembrane protein 218 isoform 2

    See identical proteins and their annotated locations for NP_001245170.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
    Source sequence(s)
    AA781367, AP001007, BC132716, BM042315, BX094574, CX870447, DA774499
    Consensus CDS
    CCDS31715.1
    UniProtKB/Swiss-Prot
    A2RU14
    Related
    ENSP00000436162.1, ENST00000527271.5
  6. NM_001258242.3NP_001245171.2  transmembrane protein 218 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
    Source sequence(s)
    AP001007
    Related
    ENSP00000436596.1, ENST00000531909.5
  7. NM_001258243.3NP_001245172.2  transmembrane protein 218 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 2. Variants 1-11 and 19-37 all encode the same isoform (2).
    Source sequence(s)
    AP001007
    Related
    ENSP00000434597.1, ENST00000532407.5
  8. NM_001258244.2NP_001245173.1  transmembrane protein 218 isoform 2

    See identical proteins and their annotated locations for NP_001245173.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
    Source sequence(s)
    AA459752, AA781367, AP001007, BC132716, BE513148, BQ681518, BX094574, CX870447
    Consensus CDS
    CCDS31715.1
    UniProtKB/Swiss-Prot
    A2RU14
    Related
    ENSP00000506979.1, ENST00000682305.1
  9. NM_001258245.2NP_001245174.1  transmembrane protein 218 isoform 2

    See identical proteins and their annotated locations for NP_001245174.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
    Source sequence(s)
    AA459752, AA781367, AP001007, BC132716, BQ223298, BU855096, BX094574, CX870447
    Consensus CDS
    CCDS31715.1
    UniProtKB/Swiss-Prot
    A2RU14
    Related
    ENSP00000433374.1, ENST00000529583.5
  10. NM_001258246.3NP_001245175.2  transmembrane protein 218 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
    Source sequence(s)
    AP001007
  11. NM_001258247.2NP_001245176.1  transmembrane protein 218 isoform 2

    See identical proteins and their annotated locations for NP_001245176.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
    Source sequence(s)
    AA459752, AA781367, AP001007, BC132716, BI856825, BX094574, CX870447
    Consensus CDS
    CCDS31715.1
    UniProtKB/Swiss-Prot
    A2RU14
    Related
    ENSP00000435526.1, ENST00000527766.5
  12. NM_001387230.1NP_001374159.1  transmembrane protein 218 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (19) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
    Source sequence(s)
    AP001007
  13. NM_001387231.1NP_001374160.1  transmembrane protein 218 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (20) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
    Source sequence(s)
    AP001007
  14. NM_001387232.1NP_001374161.1  transmembrane protein 218 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (21) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
    Source sequence(s)
    AP001007
  15. NM_001387233.1NP_001374162.1  transmembrane protein 218 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (22) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
    Source sequence(s)
    AP001007
  16. NM_001387234.1NP_001374163.1  transmembrane protein 218 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (23) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
    Source sequence(s)
    AP001007
  17. NM_001387235.1NP_001374164.1  transmembrane protein 218 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (24) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
    Source sequence(s)
    AP001007
  18. NM_001387236.1NP_001374165.1  transmembrane protein 218 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (25) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
    Source sequence(s)
    AP001007
  19. NM_001387237.1NP_001374166.1  transmembrane protein 218 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (26) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
    Source sequence(s)
    AP001007
  20. NM_001387238.1NP_001374167.1  transmembrane protein 218 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (27) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
    Source sequence(s)
    AP001007
  21. NM_001387239.1NP_001374168.1  transmembrane protein 218 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (28) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
    Source sequence(s)
    AP001007
  22. NM_001387240.1NP_001374169.1  transmembrane protein 218 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (29) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
    Source sequence(s)
    AP001007
  23. NM_001387241.1NP_001374170.1  transmembrane protein 218 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (30) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
    Source sequence(s)
    AP001007
  24. NM_001387242.1NP_001374171.1  transmembrane protein 218 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (31) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
    Source sequence(s)
    AP001007
  25. NM_001387244.1NP_001374173.1  transmembrane protein 218 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (33) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
    Source sequence(s)
    AP001007
  26. NM_001387245.1NP_001374174.1  transmembrane protein 218 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (34) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
    Source sequence(s)
    AP001007
  27. NM_001387246.1NP_001374175.1  transmembrane protein 218 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (35) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
    Source sequence(s)
    AP001007
  28. NM_001387247.1NP_001374176.1  transmembrane protein 218 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (36) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
    Source sequence(s)
    AP001007
  29. NM_001387248.1NP_001374177.1  transmembrane protein 218 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (37) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
    Source sequence(s)
    AP001007
  30. NM_001387249.1NP_001374178.1  transmembrane protein 218 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (38) encodes the longest isoform (3).
    Source sequence(s)
    AP001007
    Related
    ENSP00000436578.1, ENST00000528724.5
  31. NM_001387250.1NP_001374179.1  transmembrane protein 218 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (39), as well as variants 40-43, encodes isoform 4.
    Source sequence(s)
    AP001007
  32. NM_001387251.1NP_001374180.1  transmembrane protein 218 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (40), as well as variants 39 and 41-43, encodes isoform 4.
    Source sequence(s)
    AP001007
  33. NM_001387252.1NP_001374181.1  transmembrane protein 218 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (41), as well as variants 39, 40, 42, and 43, encodes isoform 4.
    Source sequence(s)
    AP001007
  34. NM_001387253.1NP_001374182.1  transmembrane protein 218 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (42), as well as variants 39-41 and 43, encodes isoform 4.
    Source sequence(s)
    AP001007
  35. NM_001387254.1NP_001374183.1  transmembrane protein 218 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (43), as well as variants 39-42, encodes isoform 4.
    Source sequence(s)
    AP001007
  36. NM_001387255.1NP_001374184.1  transmembrane protein 218 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (44), as well as variants 45-48, encodes isoform 5.
    Source sequence(s)
    AP001007
  37. NM_001387256.1NP_001374185.1  transmembrane protein 218 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (45), as well as variants 44 and 46-48, encodes isoform 5.
    Source sequence(s)
    AP001007
  38. NM_001387257.1NP_001374186.1  transmembrane protein 218 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (46), as well as variants 44, 45, 47, and 48, encodes isoform 5.
    Source sequence(s)
    AP001007
  39. NM_001387258.1NP_001374187.1  transmembrane protein 218 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (47), as well as variants 44-46 and 48, encodes isoform 5.
    Source sequence(s)
    AP001007
  40. NM_001387259.1NP_001374188.1  transmembrane protein 218 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (48), as well as variants 44-47, encodes isoform 5.
    Source sequence(s)
    AP001007

RNA

  1. NR_047586.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) has multiple differences, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AA781367, AP001007, BC132716, BI192743, BX094574, CX870447
  2. NR_047587.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13) lacks several alternate 5' exons, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AA781367, AP001007, BC132716, BE974033, BX094574, CX870447, DA774499
  3. NR_047588.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA459752, AA781367, AP001007, BC132716, BC144276, BX094574, CX870447, DB194956
  4. NR_047589.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15) has multiple differences, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AA459752, AA781367, AP001007, BQ225039, BX094574, CX870447
  5. NR_047590.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16) has multiple differences, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AA459752, AA781367, AP001007, BC132716, BU598207, BX094574, CX870447
  6. NR_047591.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (17) has multiple differences, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AA459752, AA781367, AP001007, BC132716, BI547955, BX094574, CX870447
  7. NR_047592.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (18) has multiple differences, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AA459752, AA781367, AP001007, BC132716, BU160644, BU598207, BX094574, CX870447
  8. NR_170600.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP001007
  9. NR_170601.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP001007
  10. NR_170602.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP001007
  11. NR_170603.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP001007
  12. NR_170604.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP001007
  13. NR_170605.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP001007
  14. NR_170606.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP001007
  15. NR_170607.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP001007
  16. NR_170608.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP001007
  17. NR_170609.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP001007
  18. NR_170610.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP001007
  19. NR_170611.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP001007
  20. NR_170612.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP001007
  21. NR_170613.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP001007

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    125094389..125111759 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718780.3XP_006718843.1  transmembrane protein 218 isoform X2

    See identical proteins and their annotated locations for XP_006718843.1

  2. XM_024448388.1XP_024304156.1  transmembrane protein 218 isoform X1

  3. XM_024448386.1XP_024304154.1  transmembrane protein 218 isoform X1

  4. XM_024448384.1XP_024304152.1  transmembrane protein 218 isoform X1

  5. XM_024448387.1XP_024304155.1  transmembrane protein 218 isoform X1

  6. XM_024448385.1XP_024304153.1  transmembrane protein 218 isoform X1

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