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TMEM218 transmembrane protein 218 [ Homo sapiens (human) ]

Gene ID: 219854, updated on 21-Dec-2019

Summary

Official Symbol
TMEM218provided by HGNC
Official Full Name
transmembrane protein 218provided by HGNC
Primary source
HGNC:HGNC:27344
See related
Ensembl:ENSG00000150433
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in fat (RPKM 5.9), adrenal (RPKM 3.3) and 25 other tissues See more
Orthologs

Genomic context

See TMEM218 in Genome Data Viewer
Location:
11q24.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (125094389..125111759, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (124964266..124981659, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 15 Neighboring gene solute carrier family 37 member 2 Neighboring gene keratin 18 pseudogene 59 Neighboring gene PKNOX2 antisense RNA 1 (head to head)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp667A247

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cilium IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080546.3NP_001074015.1  transmembrane protein 218 isoform 2

    See identical proteins and their annotated locations for NP_001074015.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AA459752, AA781367, AP001007, BC132716, BC144277, BX094574, CX870447, DB194956
    Consensus CDS
    CCDS31715.1
    UniProtKB/Swiss-Prot
    A2RU14
    Related
    ENSP00000279968.4, ENST00000279968.8
  2. NM_001258238.2NP_001245167.1  transmembrane protein 218 isoform 2

    See identical proteins and their annotated locations for NP_001245167.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon. The encoded protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AA781367, AP001007, BC132716, BI829527, BX094574, CX870447
    Consensus CDS
    CCDS31715.1
    UniProtKB/Swiss-Prot
    A2RU14
  3. NM_001258239.2NP_001245168.1  transmembrane protein 218 isoform 1

    See identical proteins and their annotated locations for NP_001245168.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein (isoform 1).
    Source sequence(s)
    AA781367, AI680968, AP001007, BC132718, BX094574, CX870447, DA899308
    UniProtKB/Swiss-Prot
    A2RU14
  4. NM_001258240.2NP_001245169.1  transmembrane protein 218 isoform 2

    See identical proteins and their annotated locations for NP_001245169.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon. The encoded protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AA781367, AP001007, BC132716, BM042315, BM928068, BX094574, CX870447, DA774499
    Consensus CDS
    CCDS31715.1
    UniProtKB/Swiss-Prot
    A2RU14
    Related
    ENSP00000436177.1, ENST00000526175.5
  5. NM_001258241.2NP_001245170.1  transmembrane protein 218 isoform 2

    See identical proteins and their annotated locations for NP_001245170.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon. The encoded protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AA781367, AP001007, BC132716, BM042315, BX094574, CX870447, DA774499
    Consensus CDS
    CCDS31715.1
    UniProtKB/Swiss-Prot
    A2RU14
    Related
    ENSP00000436162.1, ENST00000527271.5
  6. NM_001258242.2NP_001245171.1  transmembrane protein 218 isoform 1

    See identical proteins and their annotated locations for NP_001245171.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein (isoform 1).
    Source sequence(s)
    AA459752, AA781367, AP001007, BC132716, BX094574, CX870447, DB194956
    UniProtKB/Swiss-Prot
    A2RU14
  7. NM_001258243.2NP_001245172.1  transmembrane protein 218 isoform 1

    See identical proteins and their annotated locations for NP_001245172.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1, 2, 3, and 4 encode the same protein (isoform 1).
    Source sequence(s)
    AA459752, AA781367, AP001007, BC132716, BC144270, BX094574, CX870447, DB194956
    UniProtKB/Swiss-Prot
    A2RU14
  8. NM_001258244.2NP_001245173.1  transmembrane protein 218 isoform 2

    See identical proteins and their annotated locations for NP_001245173.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AA459752, AA781367, AP001007, BC132716, BE513148, BQ681518, BX094574, CX870447
    Consensus CDS
    CCDS31715.1
    UniProtKB/Swiss-Prot
    A2RU14
  9. NM_001258245.2NP_001245174.1  transmembrane protein 218 isoform 2

    See identical proteins and their annotated locations for NP_001245174.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AA459752, AA781367, AP001007, BC132716, BQ223298, BU855096, BX094574, CX870447
    Consensus CDS
    CCDS31715.1
    UniProtKB/Swiss-Prot
    A2RU14
    Related
    ENSP00000433374.1, ENST00000529583.5
  10. NM_001258246.2NP_001245175.1  transmembrane protein 218 isoform 1

    See identical proteins and their annotated locations for NP_001245175.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein (isoform 1).
    Source sequence(s)
    AA459752, AA781367, AP001007, BC132716, BQ420663, BQ653243, BX094574, CX870447
    UniProtKB/Swiss-Prot
    A2RU14
  11. NM_001258247.2NP_001245176.1  transmembrane protein 218 isoform 2

    See identical proteins and their annotated locations for NP_001245176.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AA459752, AA781367, AP001007, BC132716, BI856825, BX094574, CX870447
    Consensus CDS
    CCDS31715.1
    UniProtKB/Swiss-Prot
    A2RU14
    Related
    ENSP00000435526.1, ENST00000527766.5

RNA

  1. NR_047586.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) has multiple differences, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AA781367, AP001007, BC132716, BI192743, BX094574, CX870447
  2. NR_047587.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13) lacks several alternate 5' exons, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AA781367, AP001007, BC132716, BE974033, BX094574, CX870447, DA774499
  3. NR_047588.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA459752, AA781367, AP001007, BC132716, BC144276, BX094574, CX870447, DB194956
  4. NR_047589.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15) has multiple differences, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AA459752, AA781367, AP001007, BQ225039, BX094574, CX870447
  5. NR_047590.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16) has multiple differences, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AA459752, AA781367, AP001007, BC132716, BU598207, BX094574, CX870447
  6. NR_047591.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (17) has multiple differences, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AA459752, AA781367, AP001007, BC132716, BI547955, BX094574, CX870447
  7. NR_047592.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (18) has multiple differences, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AA459752, AA781367, AP001007, BC132716, BU160644, BU598207, BX094574, CX870447

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    125094389..125111759 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718780.3XP_006718843.1  transmembrane protein 218 isoform X2

    See identical proteins and their annotated locations for XP_006718843.1

  2. XM_006718779.3XP_006718842.1  transmembrane protein 218 isoform X2

    See identical proteins and their annotated locations for XP_006718842.1

  3. XM_017017324.1XP_016872813.1  transmembrane protein 218 isoform X3

    UniProtKB/Swiss-Prot
    A2RU14
  4. XM_024448388.1XP_024304156.1  transmembrane protein 218 isoform X1

  5. XM_024448386.1XP_024304154.1  transmembrane protein 218 isoform X1

  6. XM_006718783.3XP_006718846.1  transmembrane protein 218 isoform X3

    See identical proteins and their annotated locations for XP_006718846.1

    UniProtKB/Swiss-Prot
    A2RU14
  7. XM_024448384.1XP_024304152.1  transmembrane protein 218 isoform X1

  8. XM_024448387.1XP_024304155.1  transmembrane protein 218 isoform X1

  9. XM_024448385.1XP_024304153.1  transmembrane protein 218 isoform X1

  10. XM_017017323.1XP_016872812.1  transmembrane protein 218 isoform X3

    UniProtKB/Swiss-Prot
    A2RU14
    Related
    ENSP00000436578.1, ENST00000528724.5
  11. XM_017017322.1XP_016872811.1  transmembrane protein 218 isoform X3

    UniProtKB/Swiss-Prot
    A2RU14
  12. XM_024448389.1XP_024304157.1  transmembrane protein 218 isoform X3

    Related
    ENSP00000434597.1, ENST00000532407.5
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