Tmem165 transmembrane protein 165 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Tmem165provided by MGI
Official Full Name: transmembrane protein 165provided by MGI
Primary source: MGI:MGI:894407
See related: Ensembl:ENSMUSG00000029234 AllianceGenome:MGI:894407
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tparl; pFT27; Tpardl
Summary: Predicted to enable calcium ion transmembrane transporter activity and manganese ion transmembrane transporter activity. Predicted to be involved in cellular cation homeostasis; metal ion transport; and protein N-linked glycosylation. Predicted to be located in endosome membrane; lysosomal membrane; and trans-Golgi network membrane. Predicted to be active in Golgi apparatus. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIk. Orthologous to human TMEM165 (transmembrane protein 165). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in placenta adult (RPKM 60.9), limb E14.5 (RPKM 51.0) and 28 other tissues See more
Orthologs: human all
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Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (76331727..76357091)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (76183880..76209244)

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TMEM165 a new player in proteoglycan synthesis: loss of TMEM165 impairs elongation of chondroitin- and heparan-sulfate glycosaminoglycan chains of proteoglycans and triggers early chondrocyte differentiation and hypertrophy.
Title: TMEM165 a new player in proteoglycan synthesis: loss of TMEM165 impairs elongation of chondroitin- and heparan-sulfate glycosaminoglycan chains of proteoglycans and triggers early chondrocyte differentiation and hypertrophy.
The timing, magnitude of TMEM165 expression and its Golgi location supports a role for this Golgi Ca2+/H+ antiporter as a contributor to mammary Golgi calcium transport needs, in addition to the better-characterized roles of SPCA1 and 2.
Title: The Ca(2+)/H(+) antiporter TMEM165 expression, localization in the developing, lactating and involuting mammary gland parallels the secretory pathway Ca(2+) ATPase (SPCA1).

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH137057 (e-PCR)
- UniSTS:219146

M23568 (e-PCR)
- UniSTS:124942

AV026557 (e-PCR)
- UniSTS:185626

Homology

Homologs of the Tmem165 gene: The Tmem165 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, M.oryzae, N.crassa, A.thaliana, rice, and frog.
Orthologs from Annotation Pipeline: 502 organisms have orthologs with human gene Tmem165
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables manganese ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in Golgi calcium ion transport	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in Golgi calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in manganese ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in protein N-linked glycosylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of lysosomal lumen pH	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transmembrane protein 165

Names: TPA regulated locus; TPA-regulated locus protein; transmembrane protein 164; transmembrane protein PFT27; transmembrane protein TPARL

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011626.2 → NP_035756.2 transmembrane protein 165 precursor

See identical proteins and their annotated locations for NP_035756.2

Status: VALIDATED

Source sequence(s)

AA764070, BB623818, M23568

Consensus CDS

CCDS19359.1

UniProtKB/Swiss-Prot

P52875, Q9R292

UniProtKB/TrEMBL

A0A8C6HM28

Related

ENSMUSP00000031144.8, ENSMUST00000031144.14

Conserved Domains (3) summary

COG2119
Location:96 → 316

Gdt1; Putative Ca2+/H+ antiporter, TMEM165/GDT1 family [General function prediction only]

pfam01169
Location:242 → 311

UPF0016; Uncharacterized protein family UPF0016

pfam01621
Location:77 → 126

Fusion_gly_K; Cell fusion glycoprotein K