Format

Send to:

Choose Destination

TBATA thymus, brain and testes associated [ Homo sapiens (human) ]

Gene ID: 219793, updated on 7-Jun-2020

Summary

Official Symbol
TBATAprovided by HGNC
Official Full Name
thymus, brain and testes associatedprovided by HGNC
Primary source
HGNC:HGNC:23511
See related
Ensembl:ENSG00000166220 MIM:612640
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPATIAL; C10orf27
Summary
This gene encodes a protein that regulates thymic epithelial cell proliferation and thymus size. It has been identified as a ligand for the class I human leukocyte antigen (HLA-I) in thymus. Studies of the orthologous mouse protein suggest that it may also play a role in spermatid differentiation, as well as in neuronal morphogenesis and synaptic plasticity. Polymorphisms in this gene are associated with susceptibility for multiple sclerosis (MS). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Expression
Restricted expression toward testis (RPKM 6.9) See more
Orthologs

Genomic context

See TBATA in Genome Data Viewer
Location:
10q22.1
Exon count:
19
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (70771237..70785401, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (72530995..72545157, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr10.2252 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 14 Neighboring gene Sharpr-MPRA regulatory region 12298 Neighboring gene ribosomal protein S26 pseudogene 40 Neighboring gene sphingosine-1-phosphate lyase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ32820

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
protein TBATA
Names
stromal protein associated with thymii and lymph node homolog
thymus, brain and testes-associated protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318241.2NP_001305170.1  protein TBATA isoform a

    Status: REVIEWED

    Source sequence(s)
    AL358817
    Consensus CDS
    CCDS81471.1
    UniProtKB/TrEMBL
    A0A0A0MSR7, B7ZMN5
    Related
    ENSP00000400224.3, ENST00000456372.3
    Conserved Domains (1) summary
    pfam15256
    Location:77271
    SPATIAL; SPATIAL
  2. NM_001318242.2NP_001305171.1  protein TBATA isoform b

    Status: REVIEWED

    Source sequence(s)
    BC137543, DB512647, DC398035, HY289269
    Consensus CDS
    CCDS7308.1
    UniProtKB/Swiss-Prot
    Q96M53
    Conserved Domains (1) summary
    pfam15256
    Location:77270
    SPATIAL; SPATIAL
  3. NM_001318243.2NP_001305172.1  protein TBATA isoform c

    Status: REVIEWED

    Source sequence(s)
    BC144692, DB512647, HY289269
    UniProtKB/TrEMBL
    B7ZMN4
    Conserved Domains (1) summary
    pfam15256
    Location:77269
    SPATIAL; SPATIAL
  4. NM_152710.4NP_689923.3  protein TBATA isoform b

    Status: REVIEWED

    Source sequence(s)
    BC137544, DB512647, HY289269
    Consensus CDS
    CCDS7308.1
    UniProtKB/Swiss-Prot
    Q96M53
    Related
    ENSP00000299290.1, ENST00000299290.5
    Conserved Domains (1) summary
    pfam15256
    Location:77270
    SPATIAL; SPATIAL

RNA

  1. NR_134531.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    BC139728, DC398035, HY289269
  2. NR_134532.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358817
  3. NR_134533.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358817
  4. NR_134534.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358817
  5. NR_165441.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358817

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    70771237..70785401 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017015845.1XP_016871334.1  protein TBATA isoform X1

  2. XM_017015860.1XP_016871349.1  protein TBATA isoform X15

  3. XM_017015852.1XP_016871341.1  protein TBATA isoform X8

  4. XM_017015848.1XP_016871337.1  protein TBATA isoform X4

  5. XM_017015846.1XP_016871335.1  protein TBATA isoform X2

  6. XM_017015856.1XP_016871345.1  protein TBATA isoform X12

  7. XM_017015853.1XP_016871342.1  protein TBATA isoform X9

  8. XM_017015847.1XP_016871336.1  protein TBATA isoform X3

  9. XM_017015849.1XP_016871338.1  protein TBATA isoform X5

  10. XM_017015858.1XP_016871347.1  protein TBATA isoform X14

  11. XM_017015855.1XP_016871344.1  protein TBATA isoform X11

  12. XM_017015854.1XP_016871343.1  protein TBATA isoform X10

  13. XM_017015857.1XP_016871346.1  protein TBATA isoform X13

  14. XM_017015859.2XP_016871348.1  protein TBATA isoform X14

  15. XM_017015861.2XP_016871350.1  protein TBATA isoform X16

  16. XM_017015851.1XP_016871340.1  protein TBATA isoform X7

  17. XM_017015862.1XP_016871351.1  protein TBATA isoform X17

  18. XM_017015850.1XP_016871339.1  protein TBATA isoform X6

RNA

  1. XR_001747056.1 RNA Sequence

  2. XR_001747057.1 RNA Sequence

  3. XR_001747054.1 RNA Sequence

  4. XR_001747055.1 RNA Sequence

  5. XR_001747058.1 RNA Sequence

Support Center