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CCNY cyclin Y [ Homo sapiens (human) ]

Gene ID: 219771, updated on 25-Nov-2021

Summary

Official Symbol
CCNYprovided by HGNC
Official Full Name
cyclin Yprovided by HGNC
Primary source
HGNC:HGNC:23354
See related
Ensembl:ENSG00000108100 MIM:612786
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CCNX; CFP1; CBCP1; C10orf9
Summary
Cyclins, such as CCNY, control cell division cycles and regulate cyclin-dependent kinases (e.g., CDC2; MIM 116940) (Li et al., 2009 [PubMed 18060517]).[supplied by OMIM, May 2009]
Expression
Ubiquitous expression in testis (RPKM 35.4), brain (RPKM 17.2) and 25 other tissues See more
Orthologs
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Genomic context

See CCNY in Genome Data Viewer
Location:
10p11.21
Exon count:
14
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (35247025..35572667)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (35535953..35861595)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ATPase H+ transporting V1 subunit G1 pseudogene 4 Neighboring gene cAMP responsive element modulator Neighboring gene long intergenic non-protein coding RNA 2634 Neighboring gene RNA, U6 small nuclear 794, pseudogene Neighboring gene RNA, U6 small nuclear 1167, pseudogene Neighboring gene uncharacterized LOC107984220 Neighboring gene Sharpr-MPRA regulatory region 12265 Neighboring gene uncharacterized LOC107984221 Neighboring gene gap junction protein delta 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
GeneReviews: Not available
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ95513

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cyclin-dependent protein serine/threonine kinase regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of cyclin-dependent protein kinase holoenzyme complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of cytoplasmic cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of cytoplasmic cyclin-dependent protein kinase holoenzyme complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cyclin-Y
Names
cyc-Y
cyclin box protein 1
cyclin fold protein 1
cyclin-X
cyclin-box carrying protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282852.2NP_001269781.1  cyclin-Y isoform 3

    See identical proteins and their annotated locations for NP_001269781.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AA476431, AF413522, AF465728, AL117336, AL121749, BC094815
    Consensus CDS
    CCDS60513.1
    UniProtKB/Swiss-Prot
    Q8ND76
    Related
    ENSP00000344275.5, ENST00000339497.7
    Conserved Domains (1) summary
    pfam00134
    Location:118240
    Cyclin_N; Cyclin, N-terminal domain
  2. NM_001282853.2NP_001269782.1  cyclin-Y isoform 2

    See identical proteins and their annotated locations for NP_001269782.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. Variants 2 and 4 encode the same isoform (2), which has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AA476431, AF413522, AL117336, AL121749, BC050310, BC094815
    Consensus CDS
    CCDS7190.1
    UniProtKB/Swiss-Prot
    Q8ND76
    Related
    ENSP00000265375.9, ENST00000265375.13
    Conserved Domains (1) summary
    cd20540
    Location:112208
    CYCLIN_CCNY_like; cyclin box found in cyclin-Y (CCNY) family
  3. NM_001282854.2NP_001269783.1  cyclin-Y isoform 5

    See identical proteins and their annotated locations for NP_001269783.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (5) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AA476431, AF413522, AK303283, AL117336, AL121749, BC094815
    UniProtKB/Swiss-Prot
    Q8ND76
    UniProtKB/TrEMBL
    B7Z8E4
    Conserved Domains (1) summary
    pfam00134
    Location:10132
    Cyclin_N; Cyclin, N-terminal domain
  4. NM_145012.6NP_659449.3  cyclin-Y isoform 1

    See identical proteins and their annotated locations for NP_659449.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA476431, AF413522, AL117336, AL121749, BC094815
    Consensus CDS
    CCDS7189.1
    UniProtKB/Swiss-Prot
    Q8ND76
    Related
    ENSP00000363836.4, ENST00000374704.8
    Conserved Domains (1) summary
    cd20540
    Location:166262
    CYCLIN_CCNY_like; cyclin box found in cyclin-Y (CCNY) family
  5. NM_181698.4NP_859049.2  cyclin-Y isoform 2

    See identical proteins and their annotated locations for NP_859049.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. Variants 2 and 4 encode the same isoform (2), which has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AA476431, AF429969, AK057280, AL121749
    Consensus CDS
    CCDS7190.1
    UniProtKB/Swiss-Prot
    Q8ND76
    Related
    ENSP00000363838.1, ENST00000374706.5
    Conserved Domains (1) summary
    cd20540
    Location:112208
    CYCLIN_CCNY_like; cyclin box found in cyclin-Y (CCNY) family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    35247025..35572667
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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