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ZNF25 zinc finger protein 25 [ Homo sapiens (human) ]

Gene ID: 219749, updated on 2-Oct-2018

Summary

Official Symbol
ZNF25provided by HGNC
Official Full Name
zinc finger protein 25provided by HGNC
Primary source
HGNC:HGNC:13043
See related
Ensembl:ENSG00000175395 MIM:194528; Vega:OTTHUMG00000019344
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Zfp9; KOX19
Expression
Ubiquitous expression in brain (RPKM 11.8), adrenal (RPKM 6.3) and 24 other tissues See more
Orthologs

Genomic context

See ZNF25 in Genome Data Viewer
Location:
10p11.21
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (37949572..37976655, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (38238500..38265584, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene zinc finger protein 37C, pseudogene Neighboring gene zinc finger protein 33C, pseudogene Neighboring gene uncharacterized LOC105376499 Neighboring gene zinc finger protein 33A Neighboring gene RNA, U6 small nuclear 795, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31890, DKFZp564C206

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific NAS
Non-traceable Author Statement
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 25
Names
zinc finger protein 25 (KOX 19)
zinc finger protein KOX19

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001329647.1NP_001316576.1  zinc finger protein 25 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest isoform (a). Variants 1-3 all encode the same isoform (a).
    Source sequence(s)
    AL117337
    Conserved Domains (5) summary
    smart00349
    Location:1272
    KRAB; krueppel associated box
    COG5048
    Location:148457
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:264284
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1251
    KRAB; KRAB box
    pfam13465
    Location:248273
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001329648.1NP_001316577.1  zinc finger protein 25 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes isoform a, as do variants 1 and 3.
    Source sequence(s)
    AL117337
    Conserved Domains (5) summary
    smart00349
    Location:1272
    KRAB; krueppel associated box
    COG5048
    Location:148457
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:264284
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1251
    KRAB; KRAB box
    pfam13465
    Location:248273
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001329649.1NP_001316578.1  zinc finger protein 25 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes isoform a, as do variants 1 and 2.
    Source sequence(s)
    AL117337, DA306585
    Conserved Domains (5) summary
    smart00349
    Location:1272
    KRAB; krueppel associated box
    COG5048
    Location:148457
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:264284
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1251
    KRAB; KRAB box
    pfam13465
    Location:248273
    zf-H2C2_2; Zinc-finger double domain
  4. NM_001329650.1NP_001316579.1  zinc finger protein 25 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) encodes isoform b, as do variants 4, 6, 7, 8, and 9.
    Source sequence(s)
    AL117337
    Consensus CDS
    CCDS7195.1
    UniProtKB/Swiss-Prot
    P17030
    Conserved Domains (5) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:144453
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:260280
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:244269
    zf-H2C2_2; Zinc-finger double domain
  5. NM_001329651.1NP_001316580.1  zinc finger protein 25 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) encodes isoform b, as do variants 4, 5, 7, 8, and 9.
    Source sequence(s)
    AL117337
    Consensus CDS
    CCDS7195.1
    UniProtKB/Swiss-Prot
    P17030
    Conserved Domains (5) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:144453
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:260280
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:244269
    zf-H2C2_2; Zinc-finger double domain
  6. NM_001329652.1NP_001316581.1  zinc finger protein 25 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) encodes isoform b, as do variants 4, 5, 6, 8, and 9.
    Source sequence(s)
    AL117337
    Consensus CDS
    CCDS7195.1
    UniProtKB/Swiss-Prot
    P17030
    Conserved Domains (5) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:144453
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:260280
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:244269
    zf-H2C2_2; Zinc-finger double domain
  7. NM_001329653.1NP_001316582.1  zinc finger protein 25 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) encodes isoform b, as do variants 4, 5, 6, 7, and 9.
    Source sequence(s)
    AL117337
    Consensus CDS
    CCDS7195.1
    UniProtKB/Swiss-Prot
    P17030
    Conserved Domains (5) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:144453
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:260280
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:244269
    zf-H2C2_2; Zinc-finger double domain
  8. NM_001329654.1NP_001316583.1  zinc finger protein 25 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) encodes isoform b, as do variants 4-8.
    Source sequence(s)
    AL117337, DA113590
    Consensus CDS
    CCDS7195.1
    UniProtKB/Swiss-Prot
    P17030
    Conserved Domains (5) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:144453
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:260280
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:244269
    zf-H2C2_2; Zinc-finger double domain
  9. NM_001329655.1NP_001316584.1  zinc finger protein 25 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL117337, DA320329
  10. NM_001329656.1NP_001316585.1  zinc finger protein 25 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) encodes isoform d, as do variants 11-19.
    Source sequence(s)
    AL117337
    Conserved Domains (4) summary
    smart00349
    Location:132
    KRAB; krueppel associated box
    COG5048
    Location:108417
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:224244
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:208233
    zf-H2C2_2; Zinc-finger double domain
  11. NM_001329657.1NP_001316586.1  zinc finger protein 25 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) encodes isoform d, as do variants 11 and 13-9.
    Source sequence(s)
    AL117337
    Conserved Domains (4) summary
    smart00349
    Location:132
    KRAB; krueppel associated box
    COG5048
    Location:108417
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:224244
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:208233
    zf-H2C2_2; Zinc-finger double domain
  12. NM_001329658.1NP_001316587.1  zinc finger protein 25 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13) encodes isoform d, as do variants 11-12 and 14-19.
    Source sequence(s)
    AL117337
    Conserved Domains (4) summary
    smart00349
    Location:132
    KRAB; krueppel associated box
    COG5048
    Location:108417
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:224244
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:208233
    zf-H2C2_2; Zinc-finger double domain
  13. NM_001329659.1NP_001316588.1  zinc finger protein 25 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14) encodes isoform d, as do variants 11-13 and 15-19.
    Source sequence(s)
    AL117337
    Conserved Domains (4) summary
    smart00349
    Location:132
    KRAB; krueppel associated box
    COG5048
    Location:108417
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:224244
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:208233
    zf-H2C2_2; Zinc-finger double domain
  14. NM_001329660.1NP_001316589.1  zinc finger protein 25 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15) encodes isoform d, as do variants 11-14 and 16-19.
    Source sequence(s)
    AL117337
    Conserved Domains (4) summary
    smart00349
    Location:132
    KRAB; krueppel associated box
    COG5048
    Location:108417
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:224244
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:208233
    zf-H2C2_2; Zinc-finger double domain
  15. NM_001329661.1NP_001316590.1  zinc finger protein 25 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16) encodes isoform d, as do variants 11-15 and 17-19.
    Source sequence(s)
    AL117337
    Conserved Domains (4) summary
    smart00349
    Location:132
    KRAB; krueppel associated box
    COG5048
    Location:108417
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:224244
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:208233
    zf-H2C2_2; Zinc-finger double domain
  16. NM_001329662.1NP_001316591.1  zinc finger protein 25 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (17) encodes isoform d, as do variants 11-16 and 18-19.
    Source sequence(s)
    AL117337
    Conserved Domains (4) summary
    smart00349
    Location:132
    KRAB; krueppel associated box
    COG5048
    Location:108417
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:224244
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:208233
    zf-H2C2_2; Zinc-finger double domain
  17. NM_001329663.1NP_001316592.1  zinc finger protein 25 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (18) encodes isoform d, as do variants 11-17 and 19.
    Source sequence(s)
    AL117337
    Conserved Domains (4) summary
    smart00349
    Location:132
    KRAB; krueppel associated box
    COG5048
    Location:108417
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:224244
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:208233
    zf-H2C2_2; Zinc-finger double domain
  18. NM_001329664.1NP_001316593.1  zinc finger protein 25 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (19) encodes isoform d, as do variants 11-18.
    Source sequence(s)
    AL117337
    Conserved Domains (4) summary
    smart00349
    Location:132
    KRAB; krueppel associated box
    COG5048
    Location:108417
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:224244
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:208233
    zf-H2C2_2; Zinc-finger double domain
  19. NM_145011.3NP_659448.1  zinc finger protein 25 isoform b

    See identical proteins and their annotated locations for NP_659448.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes isoform b, as do variants 5-9.
    Source sequence(s)
    AL117337, BP229986
    Consensus CDS
    CCDS7195.1
    UniProtKB/Swiss-Prot
    P17030
    Related
    ENSP00000302222.7, OTTHUMP00000020828, ENST00000302609.7, OTTHUMT00000051214
    Conserved Domains (5) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:144453
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:260280
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:244269
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_138062.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL117337
  2. NR_138063.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL117337
  3. NR_138064.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL117337
  4. NR_138065.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL117337
  5. NR_138066.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL117337
  6. NR_138067.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL117337
  7. NR_138068.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL117337
  8. NR_138069.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL117337, DB042775

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

    Range
    37949572..37976655 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519356.2XP_011517658.1  zinc finger protein 25 isoform X2

    Conserved Domains (4) summary
    smart00349
    Location:132
    KRAB; krueppel associated box
    COG5048
    Location:108417
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:224244
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:208233
    zf-H2C2_2; Zinc-finger double domain
  2. XM_011519354.3XP_011517656.1  zinc finger protein 25 isoform X1

    See identical proteins and their annotated locations for XP_011517656.1

    Conserved Domains (5) summary
    smart00349
    Location:1272
    KRAB; krueppel associated box
    COG5048
    Location:148457
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:264284
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1251
    KRAB; KRAB box
    pfam13465
    Location:248273
    zf-H2C2_2; Zinc-finger double domain
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