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Top1 topoisomerase (DNA) I [ Mus musculus (house mouse) ]

Gene ID: 21969, updated on 7-Aug-2018

Summary

Official Symbol
Top1provided by MGI
Official Full Name
topoisomerase (DNA) Iprovided by MGI
Primary source
MGI:MGI:98788
See related
Ensembl:ENSMUSG00000070544 Vega:OTTMUSG00000001178
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Top-1; AI467334; D130064I21Rik
Expression
Ubiquitous expression in CNS E11.5 (RPKM 28.9), adrenal adult (RPKM 26.1) and 28 other tissues See more
Orthologs

Genomic context

See Top1 in Genome Data Viewer
Location:
2 H2; 2 80.96 cM
Exon count:
21
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (160645897..160722764)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (160471633..160548500)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34980 Neighboring gene predicted gene 14221 Neighboring gene phospholipase C, gamma 1 Neighboring gene zinc fingers and homeoboxes 3 Neighboring gene predicted gene, 35129

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding ISO
Inferred from Sequence Orthology
more info
 
DNA binding ISO
Inferred from Sequence Orthology
more info
 
DNA topoisomerase activity IEA
Inferred from Electronic Annotation
more info
 
DNA topoisomerase type I activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA topoisomerase type I activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA topoisomerase type I activity ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II proximal promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
chromatin DNA binding ISO
Inferred from Sequence Orthology
more info
 
chromatin binding ISO
Inferred from Sequence Orthology
more info
 
double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
isomerase activity IEA
Inferred from Electronic Annotation
more info
 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
supercoiled DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA topological change IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA topological change IDA
Inferred from Direct Assay
more info
PubMed 
DNA topological change ISO
Inferred from Sequence Orthology
more info
 
chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin remodeling ISO
Inferred from Sequence Orthology
more info
 
chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
circadian regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
embryonic cleavage IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
rRNA transcription ISO
Inferred from Sequence Orthology
more info
 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
DNA topoisomerase complex (ATP-hydrolyzing) ISO
Inferred from Sequence Orthology
more info
 
P-body ISO
Inferred from Sequence Orthology
more info
 
chromosome IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
dense fibrillar component ISO
Inferred from Sequence Orthology
more info
 
fibrillar center ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with nuclear chromosome ISO
Inferred from Sequence Orthology
more info
 
nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perikaryon IDA
Inferred from Direct Assay
more info
PubMed 
protein-DNA complex ISO
Inferred from Sequence Orthology
more info
 
replication fork protection complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
DNA topoisomerase 1
Names
DNA topoisomerase I
NP_033434.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009408.2NP_033434.2  DNA topoisomerase 1

    See identical proteins and their annotated locations for NP_033434.2

    Status: VALIDATED

    Source sequence(s)
    AK145538, AK164061, AL590414, CF733054, CF734074, CN717304, CO425650, DV645012
    Consensus CDS
    CCDS16995.1
    UniProtKB/Swiss-Prot
    Q04750
    UniProtKB/TrEMBL
    Q3TPX7, Q3ULF5
    Related
    ENSMUSP00000105094.2, OTTMUSP00000001137, ENSMUST00000109468.2, OTTMUST00000002309
    Conserved Domains (4) summary
    smart00435
    Location:362739
    TOPEUc; DNA Topoisomerase I (eukaryota)
    pfam01028
    Location:434637
    Topoisom_I; Eukaryotic DNA topoisomerase I, catalytic core
    pfam02919
    Location:217431
    Topoisom_I_N; Eukaryotic DNA topoisomerase I, DNA binding fragment
    pfam14370
    Location:697765
    Topo_C_assoc; C-terminal topoisomerase domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

    Range
    160645897..160722764
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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