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Tom1 target of myb1 trafficking protein [ Mus musculus (house mouse) ]

Gene ID: 21968, updated on 23-Jun-2021

Summary

Official Symbol
Tom1provided by MGI
Official Full Name
target of myb1 trafficking proteinprovided by MGI
Primary source
MGI:MGI:1338026
See related
Ensembl:ENSMUSG00000042870
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Expression
Ubiquitous expression in testis adult (RPKM 30.9), heart adult (RPKM 26.6) and 28 other tissues See more
Orthologs
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Genomic context

See Tom1 in Genome Data Viewer
Location:
8; 8 C1
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (75760270..75796749)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (75033642..75070121)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (77557585..77594020)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53440 Neighboring gene HMG box domain containing 4 Neighboring gene dpy-30 homolog pseudogene Neighboring gene heme oxygenase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables clathrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables clathrin binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
target of Myb protein 1
Names
target of myb1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136259.1NP_001129731.1  target of Myb protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001129731.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longer transcript and encodes the longer protein (isoform 2).
    Source sequence(s)
    AL603864
    Consensus CDS
    CCDS52600.1
    UniProtKB/TrEMBL
    Q3UDC3
    Related
    ENSMUSP00000077891.6, ENSMUST00000078847.13
    Conserved Domains (2) summary
    cd03565
    Location:12152
    VHS_Tom1; VHS domain family, Tom1 subfamily; The VHS domain is an essential part of Tom1 (Target of myb1 - retroviral oncogene) protein. The VHS domain has a superhelical structure similar to the structure of the ARM repeats and is present at the very N-termini of ...
    cd14236
    Location:214308
    GAT_TOM1; GAT domain found in target of Myb protein 1 (Tom1)
  2. NM_011622.3NP_035752.1  target of Myb protein 1 isoform 1

    See identical proteins and their annotated locations for NP_035752.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an alternate in-frame exon in the coding region compared to variant 2. The resulting protein (isoform 1) is shorter but has the same N- and C-termini compared to isoform 2.
    Source sequence(s)
    AL603864
    Consensus CDS
    CCDS52601.1
    UniProtKB/Swiss-Prot
    O88746
    UniProtKB/TrEMBL
    Q561M4
    Related
    ENSMUSP00000130854.2, ENSMUST00000165630.3
    Conserved Domains (2) summary
    cd03565
    Location:12152
    VHS_Tom1; VHS domain family, Tom1 subfamily; The VHS domain is an essential part of Tom1 (Target of myb1 - retroviral oncogene) protein. The VHS domain has a superhelical structure similar to the structure of the ARM repeats and is present at the very N-termini of ...
    cd14236
    Location:214308
    GAT_TOM1; GAT domain found in target of Myb protein 1 (Tom1)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    75760270..75796749
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017312661.2XP_017168150.1  target of Myb protein 1 isoform X1

    Conserved Domains (2) summary
    cd14236
    Location:181275
    GAT_TOM1; GAT domain found in target of Myb protein 1 (Tom1)
    cl02544
    Location:1115
    VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily
  2. XM_036153878.1XP_036009771.1  target of Myb protein 1 isoform X2

    Conserved Domains (1) summary
    cd14236
    Location:62156
    GAT_TOM1; canonical GAT domain found in target of Myb protein 1 (Tom1)
  3. XM_006530843.4XP_006530906.1  target of Myb protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006530906.1

    Conserved Domains (1) summary
    cd14236
    Location:62156
    GAT_TOM1; canonical GAT domain found in target of Myb protein 1 (Tom1)
  4. XM_006530844.4XP_006530907.1  target of Myb protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006530907.1

    Conserved Domains (1) summary
    cd14236
    Location:62156
    GAT_TOM1; canonical GAT domain found in target of Myb protein 1 (Tom1)
  5. XM_036153876.1XP_036009769.1  target of Myb protein 1 isoform X2

    Conserved Domains (1) summary
    cd14236
    Location:62156
    GAT_TOM1; canonical GAT domain found in target of Myb protein 1 (Tom1)
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