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ZCCHC24 zinc finger CCHC-type containing 24 [ Homo sapiens (human) ]

Gene ID: 219654, updated on 29-Mar-2023

Summary

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Official Symbol
ZCCHC24provided by HGNC
Official Full Name
zinc finger CCHC-type containing 24provided by HGNC
Primary source
HGNC:HGNC:26911
See related
Ensembl:ENSG00000165424 AllianceGenome:HGNC:26911
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Z3CXXC8; C10orf56
Summary
Enables RNA binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 26.2), fat (RPKM 23.1) and 23 other tissues See more
Orthologs
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Genomic context

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See ZCCHC24 in Genome Data Viewer
Location:
10q22.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (79382325..79445624, complement)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (80251666..80314699, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (81142081..81205380, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene CRISPRi-FlowFISH-validated PPIF regulatory elements GRCh37_chr10:81134127-81134627 and GRCh37_chr10:81134130-81134914 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:81135469-81136005 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81145819-81146746 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81150060-81150645 Neighboring gene CRISPRi-FlowFISH-validated PPIF regulatory element GRCh37_chr10:81159191-81159691 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81162702-81163510 Neighboring gene CRISPRi-FlowFISH-validated PPIF regulatory elements GRCh37_chr10:81163946-81164446 and GRCh37_chr10:81163953-81164453 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81165127-81165934 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81172654-81173164 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81173165-81173673 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81184235-81184736 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81194851-81195489 Neighboring gene uncharacterized LOC105378383 Neighboring gene CRISPRi-FlowFISH-validated PPIF regulatory element GRCh37_chr10:81250836-81251336

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality. Seppälä I, et al. Eur Heart J, 2014 Feb. PMID 24159190
  2. Identification of VKORC1 interaction partners by split-ubiquitin system and coimmunoprecipitation. Schaafhausen A, et al. Thromb Haemost, 2011 Feb. PMID 21103663
  3. The DNA sequence and comparative analysis of human chromosome 10. Deloukas P, et al. Nature, 2004 May 27. PMID 15164054
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. Grupe A, et al. Am J Hum Genet, 2006 Jan. PMID 16385451, Free PMC Article
  5. PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation. Choi J, et al. Cell Cycle, 2018. PMID 30209976, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ90798

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger CCHC domain-containing protein 24
Names
zinc finger, 3CxxC-type 8
zinc finger, CCHC domain containing 24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153367.4 → NP_699198.2  zinc finger CCHC domain-containing protein 24

    See identical proteins and their annotated locations for NP_699198.2

    Status: VALIDATED

    Source sequence(s)
    AL133481, BC053564
    Consensus CDS
    CCDS7359.1
    UniProtKB/Swiss-Prot
    Q8N2G6, Q8TAG0
    UniProtKB/TrEMBL
    A0A024QZP0
    Related
    ENSP00000361411.3, ENST00000372336.4
    Conserved Domains (2) summary
    COG5222
    Location:33 → 157
    COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    pfam17180
    Location:164 → 230
    zf-3CxxC_2; Zinc-binding domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    79382325..79445624 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539452.4 → XP_011537754.1  zinc finger CCHC domain-containing protein 24 isoform X1

    See identical proteins and their annotated locations for XP_011537754.1

    Conserved Domains (2) summary
    pfam13695
    Location:95 → 161
    zf-3CxxC; Zinc-binding domain
    pfam13696
    Location:59 → 79
    zf-CCHC_2; Zinc knuckle

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    80251666..80314699 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054364999.1 → XP_054220974.1  zinc finger CCHC domain-containing protein 24 isoform X1

  2. XM_054365000.1 → XP_054220975.1  zinc finger CCHC domain-containing protein 24 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N2G6.1 GenPept UniProtKB/Swiss-Prot:Q8N2G6

Gene LinkOut

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