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ZCCHC24 zinc finger CCHC-type containing 24 [ Homo sapiens (human) ]

Gene ID: 219654, updated on 17-Sep-2024

Summary

Official Symbol
ZCCHC24provided by HGNC
Official Full Name
zinc finger CCHC-type containing 24provided by HGNC
Primary source
HGNC:HGNC:26911
See related
Ensembl:ENSG00000165424 AllianceGenome:HGNC:26911
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Z3CXXC8; C10orf56
Summary
Enables RNA binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 26.2), fat (RPKM 23.1) and 23 other tissues See more
Orthologs
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Genomic context

See ZCCHC24 in Genome Data Viewer
Location:
10q22.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (79382325..79445624, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (80251666..80314699, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (81142081..81205380, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:80827637-80828482 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3623 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:80832039-80832542 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:80839841-80840350 Neighboring gene hESC enhancers GRCh37_chr10:80843535-80844106 and GRCh37_chr10:80844107-80844676 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2528 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:80847474-80848460 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:80848461-80849447 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:80850069-80850570 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:80850571-80851070 Neighboring gene CRISPRi-FlowFISH-validated PPIF regulatory elements GRCh37_chr10:80853442-80853942 and GRCh37_chr10:80853471-80853971 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:80856811-80857382 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3625 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:80860971-80861854 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:80861855-80862738 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:80862739-80863620 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:80867111-80867288 Neighboring gene zinc finger MIZ-type containing 1 Neighboring gene HNF1 motif-containing MPRA enhancer 157 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:80872521-80873111 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:80873702-80874292 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:80873112-80873701 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:80874293-80874881 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3626 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2529 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:80886414-80886932 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:80889167-80889808 Neighboring gene CRISPRi-FlowFISH-validated PPIF regulatory element GRCh37_chr10:80892363-80892863 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:80897004-80897684 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:80904675-80905613 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3627 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2531 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2532 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:80915969-80916820 Neighboring gene HNF1 motif-containing MPRA enhancer 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:80918523-80919372 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:80922057-80922728 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:80930785-80931574 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:80937580-80938196 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:80938197-80938813 Neighboring gene Sharpr-MPRA regulatory region 270 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:80941281-80941897 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:80943423-80944622 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:80944822-80945581 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:80947279-80947814 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:80947815-80948349 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:80949957-80950491 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3628 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:80960740-80961240 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:80961241-80961741 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3629 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:80969381-80970255 Neighboring gene VISTA enhancer hs1767 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:80984385-80985122 Neighboring gene Sharpr-MPRA regulatory region 8427 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:80996160-80996788 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:80996789-80997417 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:80999304-80999932 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:80999933-81000560 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:81001601-81002552 Neighboring gene CRISPRi-FlowFISH-validated PPIF regulatory elements GRCh37_chr10:81003385-81003885 and GRCh37_chr10:81003389-81003889 Neighboring gene CRISPRi-FlowFISH-validated PPIF regulatory element GRCh37_chr10:81004281-81005113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3633 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3632 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3635 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3634 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2537 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81007811-81008725 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81008726-81009639 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3637 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81015755-81016750 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81016751-81017746 Neighboring gene Sharpr-MPRA regulatory region 1120 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81023533-81024492 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3638 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:81025451-81026410 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:81033176-81034046 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81034047-81034918 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81034919-81035789 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:81039443-81039612 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3639 Neighboring gene CRISPRi-FlowFISH-validated PPIF regulatory element GRCh37_chr10:81044989-81045489 Neighboring gene H3K4me1 hESC enhancers GRCh37_chr10:81046379-81047029 and GRCh37_chr10:81045728-81046378 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2538 Neighboring gene CRISPRi-FlowFISH-validated PPIF regulatory elements GRCh37_chr10:81053513-81054274 and GRCh37_chr10:81053559-81054389 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:81064163-81065362 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81071537-81072037 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81072795-81073294 Neighboring gene CRISPRi-FlowFISH-validated PPIF regulatory elements GRCh37_chr10:81076336-81076836 to GRCh37_chr10:81076368-81076868 Neighboring gene CRISPRi-FlowFISH-validated PPIF regulatory elements GRCh37_chr10:81077051-81077551 to GRCh37_chr10:81077572-81078072 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:81078090-81078665 Neighboring gene CRISPRi-FlowFISH-validated PPIF regulatory elements GRCh37_chr10:81080832-81081332 to GRCh37_chr10:81080873-81081373 Neighboring gene CRISPRi-FlowFISH-validated PPIF regulatory elements GRCh37_chr10:81082504-81083416 to GRCh37_chr10:81082920-81083420 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3643 Neighboring gene CRISPRi-FlowFISH-validated PPIF regulatory elements GRCh37_chr10:81088372-81088872 to GRCh37_chr10:81088582-81089082 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:81091043-81092242 Neighboring gene CRISPRi-FlowFISH-validated PPIF regulatory elements GRCh37_chr10:81106892-81107469 to GRCh37_chr10:81107706-81108206 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81108973-81109473 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81111476-81111976 Neighboring gene CRISPRi-FlowFISH-validated PPIF regulatory elements GRCh37_chr10:81112809-81113784 to GRCh37_chr10:81113845-81114345 Neighboring gene CRISPRi-FlowFISH-validated PPIF regulatory element GRCh37_chr10:81115805-81116305 Neighboring gene CRISPRi-FlowFISH-validated PPIF regulatory elements GRCh37_chr10:81134127-81134627 and GRCh37_chr10:81134130-81134914 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:81135469-81136005 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81145819-81146746 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81150060-81150645 Neighboring gene peptidylprolyl isomerase F Neighboring gene CRISPRi-FlowFISH-validated PPIF regulatory element GRCh37_chr10:81159191-81159691 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81162702-81163510 Neighboring gene CRISPRi-FlowFISH-validated PPIF regulatory elements GRCh37_chr10:81163946-81164446 and GRCh37_chr10:81163953-81164453 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81165127-81165934 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81172654-81173164 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81173165-81173673 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81184235-81184736 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81194851-81195489 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2541 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2542 Neighboring gene uncharacterized LOC105378383 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3647 Neighboring gene CRISPRi-FlowFISH-validated PPIF regulatory element GRCh37_chr10:81250836-81251336 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:81257847-81258047 Neighboring gene tetrapeptide repeat homeobox 1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ90798

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger CCHC domain-containing protein 24
Names
zinc finger, 3CxxC-type 8
zinc finger, CCHC domain containing 24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153367.4NP_699198.2  zinc finger CCHC domain-containing protein 24

    Status: VALIDATED

    Source sequence(s)
    AL133481, BC053564
    Consensus CDS
    CCDS7359.1
    UniProtKB/Swiss-Prot
    Q5U5T9, Q8N2G6, Q8TAG0
    Related
    ENSP00000361411.3, ENST00000372336.4
    Conserved Domains (2) summary
    COG5222
    Location:33157
    COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    pfam17180
    Location:164230
    zf-3CxxC_2; Zinc-binding domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    79382325..79445624 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539452.4XP_011537754.1  zinc finger CCHC domain-containing protein 24 isoform X1

    Conserved Domains (2) summary
    pfam13695
    Location:95161
    zf-3CxxC; Zinc-binding domain
    pfam13696
    Location:5979
    zf-CCHC_2; Zinc knuckle

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    80251666..80314699 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054364999.1XP_054220974.1  zinc finger CCHC domain-containing protein 24 isoform X1

  2. XM_054365000.1XP_054220975.1  zinc finger CCHC domain-containing protein 24 isoform X2