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FOLH1B folate hydrolase 1B (pseudogene) [ Homo sapiens (human) ]

Gene ID: 219595, updated on 3-Dec-2022

Summary

Official Symbol
FOLH1Bprovided by HGNC
Official Full Name
folate hydrolase 1B (pseudogene)provided by HGNC
Primary source
HGNC:HGNC:13636
See related
Ensembl:ENSG00000134612 MIM:609020; AllianceGenome:HGNC:13636
Gene type
pseudo
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PSM; FOLH2; FOLHP; PSMAL; PSMA-LIKE
Summary
Enables metallocarboxypeptidase activity. Involved in C-terminal protein deglutamylation. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in duodenum (RPKM 38.8), prostate (RPKM 20.3) and 6 other tissues See more
Orthologs
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Genomic context

See FOLH1B in Genome Data Viewer
Location:
11q14.3
Exon count:
20
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (89637469..89698718)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (89557145..89618403)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (89370637..89431886)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene NADPH oxidase 4 Neighboring gene H3 histone pseudogene 34 Neighboring gene U2 spliceosomal RNA Neighboring gene UBTF like 10 (pseudogene) Neighboring gene tripartite motif containing 77

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Other Names

  • N-acetylated-alpha-linked-acidic dipeptidase
  • cell growth-inhibiting gene 26 protein
  • folate hydrolase 2
  • prostate-specific membrane antigen-like protein
  • putative N-acetylated-alpha-linked acidic dipeptidase
  • putative folate hydrolase 1B

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables dipeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metallocarboxypeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in C-terminal protein deglutamylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular exosome HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
putative N-acetylated-alpha-linked acidic dipeptidase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_175944.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP003122

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    89637469..89698718
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047426532.1XP_047282488.1  putative N-acetylated-alpha-linked acidic dipeptidase isoform X1

    Related
    ENST00000529567.6
  2. XM_047426533.1XP_047282489.1  putative N-acetylated-alpha-linked acidic dipeptidase isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    89557145..89618403
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_003258.2: Suppressed sequence

    Description
    NG_003258.2: This RefSeq was permanently suppressed because it is primarily UTR sequence.
  2. NM_001395847.1: Suppressed sequence

    Description
    NM_001395847.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
  3. NM_153696.3: Suppressed sequence

    Description
    NM_153696.3: This RefSeq was removed because currently there is support for the transcript but not for the protein.