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Tnnt1 troponin T1, skeletal, slow [ Mus musculus (house mouse) ]

Gene ID: 21955, updated on 5-Mar-2023

Summary

Official Symbol
Tnnt1provided by MGI
Official Full Name
troponin T1, skeletal, slowprovided by MGI
Primary source
MGI:MGI:1333868
See related
Ensembl:ENSMUSG00000064179 AllianceGenome:MGI:1333868
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tnt; sTnT; ssTnT
Summary
This gene encodes the slow skeletal tropomyosin-binding subunit of the troponin complex and plays an essential role in the regulation of striated muscle contraction. In humans, mutations in this gene are associated with nemaline myopathy type 5. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2013]
Expression
Biased expression in limb E14.5 (RPKM 26.9), CNS E11.5 (RPKM 6.4) and 5 other tissues See more
Orthologs
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Genomic context

See Tnnt1 in Genome Data Viewer
Location:
7 A1; 7 2.6 cM
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (4507568..4518974, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (4504569..4515975, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene retinol dehydrogenase 13 (all-trans and 9-cis) Neighboring gene RIKEN cDNA D630041G03 gene Neighboring gene EPS8-like 1 Neighboring gene protein phosphatase 1, regulatory subunit 12C Neighboring gene troponin I, cardiac 3 Neighboring gene dynein, axonemal assembly factor 3 Neighboring gene synaptotagmin V

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables tropomyosin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables tropomyosin binding ISO
Inferred from Sequence Orthology
more info
 
enables troponin T binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables troponin T binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of troponin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of troponin complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
troponin T, slow skeletal muscle
Names
skeletal muscle slow-twitch TnT

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277903.1NP_001264832.1  troponin T, slow skeletal muscle isoform 1

    See identical proteins and their annotated locations for NP_001264832.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC161218
    Consensus CDS
    CCDS71880.1
    UniProtKB/Swiss-Prot
    O88346, Q9QUP7
    UniProtKB/TrEMBL
    A0A8C6GCJ6
    Related
    ENSMUSP00000104228.3, ENSMUST00000108587.9
    Conserved Domains (1) summary
    pfam00992
    Location:69205
    Troponin
  2. NM_001277904.1NP_001264833.1  troponin T, slow skeletal muscle isoform 3

    See identical proteins and their annotated locations for NP_001264833.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. This results in a shorter protein (isoform 3, also known as low Mr isoform), compared to isoform 1.
    Source sequence(s)
    AC161218
    Consensus CDS
    CCDS71879.1
    UniProtKB/Swiss-Prot
    O88346
    UniProtKB/TrEMBL
    A0A8C6GCK8
    Related
    ENSMUSP00000129626.2, ENSMUST00000163710.8
    Conserved Domains (1) summary
    pfam00992
    Location:57193
    Troponin
  3. NM_001360154.1NP_001347083.1  troponin T, slow skeletal muscle isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.
    Source sequence(s)
    AC161218
    Related
    ENSMUSP00000128476.2, ENSMUST00000166268.8
    Conserved Domains (1) summary
    pfam00992
    Location:58194
    Troponin
  4. NM_001417401.1NP_001404330.1  troponin T, slow skeletal muscle isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC161218
  5. NM_001417402.1NP_001404331.1  troponin T, slow skeletal muscle isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC161218
  6. NM_011618.2NP_035748.1  troponin T, slow skeletal muscle isoform 2

    See identical proteins and their annotated locations for NP_035748.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2, also known as high Mr isoform 2), compared to isoform 1.
    Source sequence(s)
    AK160226
    Consensus CDS
    CCDS51973.1
    UniProtKB/Swiss-Prot
    O88346
    UniProtKB/TrEMBL
    Q3TVB8
    Related
    ENSMUSP00000071704.7, ENSMUST00000071798.13
    Conserved Domains (1) summary
    pfam00992
    Location:68204
    Troponin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    4507568..4518974 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017322114.2XP_017177603.1  troponin T, slow skeletal muscle isoform X4

    Conserved Domains (1) summary
    pfam00992
    Location:97233
    Troponin
  2. XM_017322113.2XP_017177602.1  troponin T, slow skeletal muscle isoform X3

    Conserved Domains (1) summary
    pfam00992
    Location:98234
    Troponin
  3. XM_017322112.2XP_017177601.1  troponin T, slow skeletal muscle isoform X2

    Conserved Domains (1) summary
    pfam00992
    Location:108244
    Troponin
  4. XM_017322111.2XP_017177600.1  troponin T, slow skeletal muscle isoform X1

    Conserved Domains (1) summary
    pfam00992
    Location:109245
    Troponin
  5. XM_011250478.3XP_011248780.1  troponin T, slow skeletal muscle isoform X6

    Conserved Domains (1) summary
    pfam00992
    Location:88224
    Troponin
  6. XM_011250477.3XP_011248779.1  troponin T, slow skeletal muscle isoform X5

    Conserved Domains (1) summary
    pfam00992
    Location:89225
    Troponin