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MED19 mediator complex subunit 19 [ Homo sapiens (human) ]

Gene ID: 219541, updated on 5-Jan-2022

Summary

Official Symbol
MED19provided by HGNC
Official Full Name
mediator complex subunit 19provided by HGNC
Primary source
HGNC:HGNC:29600
See related
Ensembl:ENSG00000156603 MIM:612385
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LCMR1; DT2P1G7; MED19AS
Summary
The protein encoded by this gene is a subunit of the Mediator complex, which binds to gene-specific regulatory factors and provides support for the basal RNA polymerase II transcription machinery. This gene has been implicated in the growth of several types of cancer, and inhibition of its expression inhibits the growth and spread of these cancers. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Expression
Ubiquitous expression in testis (RPKM 7.0), brain (RPKM 5.0) and 25 other tissues See more
Orthologs
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Genomic context

See MED19 in Genome Data Viewer
Location:
11q12.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (57703709..57712215, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (57471181..57479795, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene cleavage factor polyribonucleotide kinase subunit 1 Neighboring gene zinc finger DHHC-type palmitoyltransferase 5 Neighboring gene TMX2-CTNND1 readthrough (NMD candidate) Neighboring gene peptidylprolyl isomerase A pseudogene 42 Neighboring gene thioredoxin related transmembrane protein 2 Neighboring gene selenoprotein H Neighboring gene BTB domain containing 18

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of mediator complex subunit 19 (MED19) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed
Knockdown of mediator complex subunit 19 (MED19) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat Knockdown of MED19 by siRNAs inhibits HIV LTR-beta-gal activation in the Tat transactivation assay PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
 
enables transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of core mediator complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mediator of RNA polymerase II transcription subunit 19
Names
lung cancer metastasis-related protein 1
mediator of RNA polymerase II transcription, subunit 19 homolog
putative mediator subunit MED19AS protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317078.4NP_001304007.2  mediator of RNA polymerase II transcription subunit 19 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AP000662
    Consensus CDS
    CCDS86203.1
    Related
    ENSP00000416227.4, ENST00000431606.5
    Conserved Domains (1) summary
    pfam10278
    Location:63233
    Med19; Mediator of RNA pol II transcription subunit 19
  2. NM_153450.4NP_703151.3  mediator of RNA polymerase II transcription subunit 19 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AA972146, BC037223, DB457116
    Consensus CDS
    CCDS7966.2
    Related
    ENSP00000337340.4, ENST00000337672.9
    Conserved Domains (1) summary
    pfam10278
    Location:63194
    Med19; Mediator of RNA pol II transcription subunit 19

RNA

  1. NR_157587.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP000662

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    57703709..57712215 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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